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Article

Efficacy and safety of nanosomal docetaxel lipid suspension based chemotherapy in metastatic ovarian carcinoma: A retrospective study

  • Authors:
    • Sundaram Subramanian
    • Aseem Samar
    • Nisarg Joshi
    • Jaykumar Sejpal
    • Mujtaba A. Khan
    • Imran Ahmad
  • View Affiliations / Copyright

    Affiliations: VS Hospital, Madras Cancer Institute, Advanced Cancer Care, Chennai, Tamil Nadu 600031, India, Bhagwan Mahaveer Cancer Hospital and Research Centre, Jaipur, Rajasthan 302017, India, Medical Affairs and Clinical Development, Intas Pharmaceuticals Ltd., Sola, Ahmedabad, Gujarat 380054, India, Jina Pharmaceuticals Inc., Libertyville, IL 60048, USA
  • Article Number: 162
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    Published online on: June 16, 2021
       https://doi.org/10.3892/mco.2021.2324
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Abstract

The aim of the current study was to assess the efficacy and safety of nanosomal docetaxel lipid suspension (NDLS) based chemotherapy in patients with metastatic epithelial ovarian carcinoma. In the present multicenter study, the medical records of patients who received NDLS (60‑75 mg/m2; 3‑weekly cycles) based chemotherapy for metastatic epithelial ovarian cancer in routine clinical care were retrospectively evaluated. Patients were followed‑up from September 2014 until September 2018. The efficacy endpoints were the overall response rate (ORR) and disease control rate measured in accordance with the Response Evaluation Criteria in Solid Tumours 1.1. Overall survival (OS) and safety were also evaluated. Of the 13 patients evaluated, 46.2% (6/13) received NDLS‑based first‑line chemotherapy and 53.8% (7/13) patients received second‑line chemotherapy [platinum‑sensitive, 57.1% (4/7); platinum‑resistant, 42.9% (3/7)]. The ORRs were 60.0% (3/5) and 57.1% (4/7) for patients receiving first‑ and second‑line chemotherapy, respectively. The estimated median OS for patients receiving NDLS‑based first‑line chemotherapy was 17.4 months (follow‑up duration, 4.3‑49.4 months). The estimated median OS was 26.1 months (follow‑up duration, 5.1‑37.5 months) in patients with platinum‑sensitive disease, whereas the OS was 14.8 months (follow‑up duration, 3.5‑14.8 months) in patients with platinum‑resistant disease. No grade III/IV adverse events (AEs) were observed; ≥1 AE in grade I‑II was reported in 84.6% (11/13) of patients. Overall, NDLS‑based chemotherapy was efficacious and well‑tolerated in the management of metastatic epithelial ovarian carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Subramanian S, Samar A, Joshi N, Sejpal J, Khan MA and Ahmad I: Efficacy and safety of nanosomal docetaxel lipid suspension based chemotherapy in metastatic ovarian carcinoma: A retrospective study. Mol Clin Oncol 15: 162, 2021.
APA
Subramanian, S., Samar, A., Joshi, N., Sejpal, J., Khan, M.A., & Ahmad, I. (2021). Efficacy and safety of nanosomal docetaxel lipid suspension based chemotherapy in metastatic ovarian carcinoma: A retrospective study. Molecular and Clinical Oncology, 15, 162. https://doi.org/10.3892/mco.2021.2324
MLA
Subramanian, S., Samar, A., Joshi, N., Sejpal, J., Khan, M. A., Ahmad, I."Efficacy and safety of nanosomal docetaxel lipid suspension based chemotherapy in metastatic ovarian carcinoma: A retrospective study". Molecular and Clinical Oncology 15.2 (2021): 162.
Chicago
Subramanian, S., Samar, A., Joshi, N., Sejpal, J., Khan, M. A., Ahmad, I."Efficacy and safety of nanosomal docetaxel lipid suspension based chemotherapy in metastatic ovarian carcinoma: A retrospective study". Molecular and Clinical Oncology 15, no. 2 (2021): 162. https://doi.org/10.3892/mco.2021.2324
Copy and paste a formatted citation
x
Spandidos Publications style
Subramanian S, Samar A, Joshi N, Sejpal J, Khan MA and Ahmad I: Efficacy and safety of nanosomal docetaxel lipid suspension based chemotherapy in metastatic ovarian carcinoma: A retrospective study. Mol Clin Oncol 15: 162, 2021.
APA
Subramanian, S., Samar, A., Joshi, N., Sejpal, J., Khan, M.A., & Ahmad, I. (2021). Efficacy and safety of nanosomal docetaxel lipid suspension based chemotherapy in metastatic ovarian carcinoma: A retrospective study. Molecular and Clinical Oncology, 15, 162. https://doi.org/10.3892/mco.2021.2324
MLA
Subramanian, S., Samar, A., Joshi, N., Sejpal, J., Khan, M. A., Ahmad, I."Efficacy and safety of nanosomal docetaxel lipid suspension based chemotherapy in metastatic ovarian carcinoma: A retrospective study". Molecular and Clinical Oncology 15.2 (2021): 162.
Chicago
Subramanian, S., Samar, A., Joshi, N., Sejpal, J., Khan, M. A., Ahmad, I."Efficacy and safety of nanosomal docetaxel lipid suspension based chemotherapy in metastatic ovarian carcinoma: A retrospective study". Molecular and Clinical Oncology 15, no. 2 (2021): 162. https://doi.org/10.3892/mco.2021.2324
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