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Role of RHOC in evaluating an adverse prognosis in patients with glioma and its potential prognostic value

  • Authors:
    • Bo Zhang
    • Jiawei Yao
    • Xiaoyu Lian
    • Binfeng Liu
    • Yanbiao Wang
    • Hongbo Wang
    • Jialin Wang
    • Mengjun Zhang
    • Yaoye Zhao
    • Yongjie Zhu
    • Runze Liu
    • Yanzheng Gao
  • View Affiliations / Copyright

    Affiliations: Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, P.R. China, Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Department of Surgery of Spine and Spinal Cord, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, P.R. China, Department of Gynecology Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150086, P.R. China, Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, Henan International Joint Laboratory of Intelligentized Orthopedics Innovation and Transformation, Henan Key Laboratory for Intelligent Precision Orthopedics, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan 450003, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 171
    |
    Published online on: June 29, 2021
       https://doi.org/10.3892/mco.2021.2333
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Abstract

In recent years, major discoveries have indicated that Ras homology family member C (RHOC) is involved in the occurrence and pathological progression of a number of malignant tumours; nevertheless, the role served by RHOC in glioma remains unclear. The present study aimed to gain further insight into the biological function and expression of RHOC in human glioma based on the Chinese Glioma Genome Atlas (CGGA). The current study analysed ~1,000 glioma samples from the CGGA. First, RHOC expression was analysed according to the clinical features associated with the prognosis of glioma, such as clinical stage, histological type and age. Second, the Kaplan‑Meier method was used, revealing that the survival rate of patients with glioma with high RHOC expression was significantly lower than that of patients with low RHOC expression. Receiver operating characteristic curve analysis indicated that RHOC had moderate diagnostic value for patients with glioma. Gene set enrichment analysis indirectly indicated that RHOC mainly participated in the pathological mechanism of glioma through p53, extracellular matrix receptor interaction and focal adhesion. Finally, the aforementioned results were further verified using The Cancer Genome Atlas data and reverse transcription‑quantitative PCR technology. To the best of our knowledge, the present study was the first comprehensive in‑depth analysis of RHOC, revealing the potential value of RHOC as a novel oncogene in glioma. The current study provided a novel potential biomarker for the diagnosis and prognosis of glioma, and re‑examined the pathological mechanism of glioma from a new perspective.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel R, Torre L and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018.PubMed/NCBI View Article : Google Scholar

2 

Wang H, Xu T, Huang Q, Jin W and Chen J: Immunotherapy for malignant glioma: Current status and future directions. Trends Pharmacol Sci. 41:123–138. 2020.PubMed/NCBI View Article : Google Scholar

3 

Kong Z, Yan C, Zhu R, Wang J, Wang Y, Wang Y, Wang R, Feng F and Ma W: Imaging biomarkers guided anti-angiogenic therapy for malignant gliomas. Neuroimage Clin. 20:51–60. 2018.PubMed/NCBI View Article : Google Scholar

4 

Delgado-López P, Corrales-García E, Martino J, Lastra-Aras E and Dueñas-Polo M: Diffuse low-grade glioma: A review on the new molecular classification, natural history and current management strategies. Clin Transl Oncol. 19:931–944. 2017.PubMed/NCBI View Article : Google Scholar

5 

Ho VK, Reijneveld JC, Enting RH, Bienfait HP, Robe P, Baumert BG and Visser O: Dutch Society for Neuro-Oncology (LWNO). Changing incidence and improved survival of gliomas. Eur J Cancer. 50:2309–2318. 2014.PubMed/NCBI View Article : Google Scholar

6 

Okuyama A, Shibata A and Nishimoto H: Critical points for interpreting patients' survival rate using cancer registries: A literature review. J Epidemiol. 28:61–66. 2018.PubMed/NCBI View Article : Google Scholar

7 

Gao W, Li H, Liu Y, Zhang Y, Zhao H and Liu F: Long non-coding RNA FLVCR1-AS1 promotes glioma cell proliferation and invasion by negatively regulating miR-30b-3p. Mol Med Rep. 22:723–732. 2020.PubMed/NCBI View Article : Google Scholar

8 

Vuong HG, Altibi AMA, Duong UNP, Ngo HTT, Pham TQ, Chan AK, Park CK, Fung KM and Hassell L: TERT promoter mutation and its interaction with IDH mutations in glioma: Combined TERT promoter and IDH mutations stratifies lower-grade glioma into distinct survival subgroups-a meta-analysis of aggregate data. Crit Rev Oncol Hematol. 120:1–9. 2017.PubMed/NCBI View Article : Google Scholar

9 

Ham SW, Jeon HY, Jin X, Kim EJ, Kim JK, Shin YJ, Lee Y, Kim SH, Lee SY, Seo S, et al: TP53 Gain-of-function mutation promotes inflammation in glioblastoma. Cell Death Differ. 26:409–425. 2019.PubMed/NCBI View Article : Google Scholar

10 

Ostrom QT, Bauchet L, Davis FG, Deltour I, Fisher JL, Langer CE, Pekmezci M, Schwartzbaum JA, Turner MC, Walsh KM, et al: The epidemiology of glioma in adults: A ‘state of the science’ review. Neuro Oncol. 16:896–913. 2014.PubMed/NCBI View Article : Google Scholar

11 

Thomas P, Pranatharthi A, Ross C and Srivastava S: RhoC: A fascinating journey from a cytoskeletal organizer to a cancer stem cell therapeutic target. J Exp Clin Cancer Res. 38(328)2019.PubMed/NCBI View Article : Google Scholar

12 

Wu Y, Chen Y, Sang J and Xu W: RhoC protein stimulates migration of gastric cancer cells through interaction with scaffold protein IQGAP1. Mol Med Rep. 4:697–703. 2011.PubMed/NCBI View Article : Google Scholar

13 

Zhao ZH, Tian Y, Yang JP, Zhou J and Chen KS: RhoC, vascular endothelial growth factor and microvascular density in esophageal squamous cell carcinoma. World J Gastroenterol. 21:905–912. 2015.PubMed/NCBI View Article : Google Scholar

14 

Yang H, Liang J, Zhou J, Mi J, Ma K, Fan Y, Ning J, Wang C, Wei X and Li E: Knockdown of RHOC by shRNA suppresses invasion and migration of cholangiocellular carcinoma cells via inhibition of MMP2, MMP3, MMP9 and epithelial-mesenchymal transition. Mol Med Rep. 13:5255–5261. 2016.PubMed/NCBI View Article : Google Scholar

15 

Zhao Y, Zong ZH and Xu HM: RhoC expression level is correlated with the clinicopathological characteristics of ovarian cancer and the expression levels of ROCK-I, VEGF, and MMP9. Gynecol Oncol. 116:563–571. 2010.PubMed/NCBI View Article : Google Scholar

16 

Zhang HZ, Liu JG, Wei YP, Wu C, Cao YK and Wang M: Expression of G3BP and RhoC in esophageal squamous carcinoma and their effect on prognosis. World J Gastroenterol. 13:4126–4130. 2007.PubMed/NCBI View Article : Google Scholar

17 

Lang S, Busch H, Boerries M, Brummer T, Timme S, Lassmann S, Aktories K and Schmidt G: Specific role of RhoC in tumor invasion and metastasis. Oncotarget. 8:87364–87378. 2017.PubMed/NCBI View Article : Google Scholar

18 

Arisanty D, Harahap W, Khambri D, Rustam R, Aliska G, Achyar A and Menra JP: The comparison of RhoC and PI3K gene expression on the breast cancer tissue and benign tumour tissue. Open Access Maced J Med Sci. 7:1911–1916. 2019.PubMed/NCBI View Article : Google Scholar

19 

Shen Y, Bu L, Li R, Chen Z, Tian F and Ge Q: Expression and biological interaction network of RHOC for hepatic carcinoma with metastasis in PBMC samples. Onco Targets Ther. 12:9117–9128. 2019.PubMed/NCBI View Article : Google Scholar

20 

Bellovin DI, Simpson KJ, Danilov T, Maynard E, Rimm DL, Oettgen P and Mercurio AM: Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma. Oncogene. 25:6959–6967. 2006.PubMed/NCBI View Article : Google Scholar

21 

Wang HB, Liu XP, Liang J, Yang K, Sui AH and Liu YJ: Expression of RhoA and RhoC in colorectal carcinoma and its relations with clinicopathological parameters. Clin Chem Lab Med. 47:811–817. 2009.PubMed/NCBI View Article : Google Scholar

22 

Xie S, Zhu M, Lv G, Zhang Q and Wang G: The role of RhoC in the proliferation and apoptosis of hepatocellular carcinoma cells. Med Oncol. 29:1802–1809. 2012.PubMed/NCBI View Article : Google Scholar

23 

Tumur Z, Katebzadeh S, Guerra C, Bhushan L, Alkam T and Henson BS: RhoC mediates epidermal growth factor-stimulated migration and invasion in head and neck squamous cell carcinoma. Neoplasia. 17:141–151. 2015.PubMed/NCBI View Article : Google Scholar

24 

Guo JQ, Zheng QH, Chen H, Chen L, Xu JB, Chen MY, Lu D, Wang ZH, Tong HF and Lin S: Ginsenoside Rg3 inhibition of vasculogenic mimicry in pancreatic cancer through downregulation of VE-cadherin/EphA2/MMP9/MMP2 expression. Int J Oncol. 45:1065–1072. 2014.PubMed/NCBI View Article : Google Scholar

25 

Kleer CG, Griffith KA, Sabel MS, Gallagher G, van Golen KL, Wu ZF and Merajver SD: RhoC-GTPase is a novel tissue biomarker associated with biologically aggressive carcinomas of the breast. Breast Cancer Res Treat. 93:101–110. 2005.PubMed/NCBI View Article : Google Scholar

26 

Zhang HJ, Tao J, Sheng L, Hu X, Rong RM, Xu M and Zhu TY: Twist2 promotes kidney cancer cell proliferation and invasion by regulating ITGA6 and CD44 expression in the ECM-receptor interaction pathway. Onco Targets Ther. 9:1801–1812. 2016.PubMed/NCBI View Article : Google Scholar

27 

Liu Z, Shen F, Wang H, Li A, Wang J, Du L, Liu B, Zhang B, Lian X, Pang B, et al: Abnormally high expression of HOXA2 as an independent factor for poor prognosis in glioma patients. Cell Cycle. 19:1632–1640. 2020.PubMed/NCBI View Article : Google Scholar

28 

Sloan KE, Stewart JK, Treloar AF, Matthews RT and Jay DG: CD155/PVR enhances glioma cell dispersal by regulating adhesion signaling and focal adhesion dynamics. Cancer Res. 65:10930–10937. 2005.PubMed/NCBI View Article : Google Scholar

29 

Fan Y, Potdar AA, Gong Y, Eswarappa SM, Donnola S, Lathia JD, Hambardzumyan D, Rich JN and Fox PL: Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation. Nat Cell Biol. 16:445–456. 2014.PubMed/NCBI View Article : Google Scholar

30 

Mure H, Matsuzaki K, Kitazato KT, Mizobuchi Y, Kuwayama K, Kageji T and Nagahiro S: Akt2 and Akt3 play a pivotal role in malignant gliomas. Neuro Oncol. 12:221–232. 2010.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhang B, Yao J, Lian X, Liu B, Wang Y, Wang H, Wang J, Zhang M, Zhao Y, Zhu Y, Zhu Y, et al: Role of RHOC in evaluating an adverse prognosis in patients with glioma and its potential prognostic value. Mol Clin Oncol 15: 171, 2021.
APA
Zhang, B., Yao, J., Lian, X., Liu, B., Wang, Y., Wang, H. ... Gao, Y. (2021). Role of RHOC in evaluating an adverse prognosis in patients with glioma and its potential prognostic value. Molecular and Clinical Oncology, 15, 171. https://doi.org/10.3892/mco.2021.2333
MLA
Zhang, B., Yao, J., Lian, X., Liu, B., Wang, Y., Wang, H., Wang, J., Zhang, M., Zhao, Y., Zhu, Y., Liu, R., Gao, Y."Role of RHOC in evaluating an adverse prognosis in patients with glioma and its potential prognostic value". Molecular and Clinical Oncology 15.3 (2021): 171.
Chicago
Zhang, B., Yao, J., Lian, X., Liu, B., Wang, Y., Wang, H., Wang, J., Zhang, M., Zhao, Y., Zhu, Y., Liu, R., Gao, Y."Role of RHOC in evaluating an adverse prognosis in patients with glioma and its potential prognostic value". Molecular and Clinical Oncology 15, no. 3 (2021): 171. https://doi.org/10.3892/mco.2021.2333
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang B, Yao J, Lian X, Liu B, Wang Y, Wang H, Wang J, Zhang M, Zhao Y, Zhu Y, Zhu Y, et al: Role of RHOC in evaluating an adverse prognosis in patients with glioma and its potential prognostic value. Mol Clin Oncol 15: 171, 2021.
APA
Zhang, B., Yao, J., Lian, X., Liu, B., Wang, Y., Wang, H. ... Gao, Y. (2021). Role of RHOC in evaluating an adverse prognosis in patients with glioma and its potential prognostic value. Molecular and Clinical Oncology, 15, 171. https://doi.org/10.3892/mco.2021.2333
MLA
Zhang, B., Yao, J., Lian, X., Liu, B., Wang, Y., Wang, H., Wang, J., Zhang, M., Zhao, Y., Zhu, Y., Liu, R., Gao, Y."Role of RHOC in evaluating an adverse prognosis in patients with glioma and its potential prognostic value". Molecular and Clinical Oncology 15.3 (2021): 171.
Chicago
Zhang, B., Yao, J., Lian, X., Liu, B., Wang, Y., Wang, H., Wang, J., Zhang, M., Zhao, Y., Zhu, Y., Liu, R., Gao, Y."Role of RHOC in evaluating an adverse prognosis in patients with glioma and its potential prognostic value". Molecular and Clinical Oncology 15, no. 3 (2021): 171. https://doi.org/10.3892/mco.2021.2333
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