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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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October-2021 Volume 15 Issue 4

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Case Report

A rare case of extrahepatic biliary mucinous cystic neoplasm in a middle‑aged woman: A case report

  • Authors:
    • Anna Paspala
    • Nikolaos Machairas
    • Vasileia Damaskou
    • Vasileia Ntomi
    • Stylianos Kykalos
    • Anastasios Machairas
    • Dimitrios Schizas
  • View Affiliations / Copyright

    Affiliations: Third Department of Surgery, National and Kapodistrian University of Athens, Attikon University Hospital, 12462 Athens, Greece, Second Department of Propaedeutic Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, 11527 Athens, Greece, Second Department of Pathology, National and Kapodistrian University of Athens, Attikon University Hospital, 12462 Athens, Greece, First Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, 11527 Athens, Greece
  • Article Number: 196
    |
    Published online on: July 29, 2021
       https://doi.org/10.3892/mco.2021.2358
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Abstract

Biliary mucinous cystic neoplasms are very rare tumors of the biliary tract with malignant potential. Preoperative diagnosis is challenging, as clinical, biochemical and radiological features are not specific. Surgical resection with negative margins is the gold standard treatment for these uncommon lesions. A 55‑year‑old woman presented at the Third Department of Surgery (Attikon University Hospital, Athens, Greece) with a history of mild right upper quadrant (RUQ) abdominal pain and jaundice. A 2‑cm lesion in the distal common bile was identified by imaging. Following discussion in our multidisciplinary board meeting the patient underwent a pylorus preserving pancreatoduodenectomy, and histopathological examination revealed an ovarian‑stromal type intraductal mucinous cystic neoplasm of the extra hepatic biliary. Since biliary mucinous cystic neoplasms are characterized by malignant transformation and high rates of recurrence, surgical resection with negative margins is the treatment of choice for both non‑invasive and invasive biliary mucinous cystic neoplasms.
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1 

Dixon E, Sutherland FR, Mitchell P, McKinnon G and Nayak V: Cystadenomas of the liver: A spectrum of disease. Can J Surg. 44:371–376. 2001.PubMed/NCBI

2 

Rodriguez RM, Barrio M, Parker ML, Saeed O, Sherman S and Ceppa EP: Mucinous cystic neoplasms of the liver: Presence of biliary communication. J Surg Case Rep. 2019(rjz364)2019.PubMed/NCBI View Article : Google Scholar

3 

Tsui WMS, Adsay NV, Crawford JM, Hurban R and Kloppel G WA: Mucinous cystic neoplasms of the liver. In: WHO Classification of Tumours of the Digestive System. 4th edition.Bosman FT, Carneiro F, Hruban RH and Theise ND, (eds). International Agency for Research on Cancer, Lyon, pp236-238, 2010.

4 

Metussin A, Telisinghe P, Kok K and Chong V: Extrahepatic biliary cystadenoma: A rare cause of biliary obstruction. Oman Med J. 30:66–68. 2015.PubMed/NCBI View Article : Google Scholar

5 

Albores-Saavedra J, Córdova-Ramón JC, Chablé-Montero F, Dorantes-Heredia R and Henson DE: Cystadenomas of the liver and extrahepatic bile ducts: Morphologic and immunohistochemical characterization of the biliary and intestinal variants. Ann Diagn Pathol. 19:124–129. 2015.PubMed/NCBI View Article : Google Scholar

6 

Thomas KT, Welch D, Trueblood A, Sulur P, Wise P, Gorden DL, Chari RS, Wright JK Jr, Washington K and Pinson CW: Effective treatment of biliary cystadenoma. Ann Surg. 241:769–775. 2005.PubMed/NCBI View Article : Google Scholar

7 

Fragulidis GP, Vezakis AI, Konstantinidis CG, Chondrogiannis KK, Primetis ES, Kondi-Pafiti A and Polydorou AA: Diagnostic and therapeutic challenges of intrahepatic biliary cystadenoma and cystadenocarcinoma: A report of 10 cases and review of the literature. Int Surg. 100:1212–1219. 2015.PubMed/NCBI View Article : Google Scholar

8 

Teng XD, Hamilton SR and Aaltonen LA (eds.): World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System. IARC Press, Lyon, 2000. Zhonghua Bing Li Xue Za Zhi. 34:544–546. 2005.(In Chinese).

9 

Anand S, Chandrasekar S, Raja K and Pottakkat B: Mucinous cystic neoplasm of the liver with biliary communication: An exception to the current classification. BMJ Case Rep. 12:10–12. 2019.PubMed/NCBI View Article : Google Scholar

10 

Pattarapuntakul T, Ovartlarnporn B and Sottisuporn J: Mucinous cystic neoplasm of the liver with extrahepatic growth presenting with ascending cholangitis diagnosed by endoscopic ultrasound features: A case report. J Med Case Rep. 12(33)2018.PubMed/NCBI View Article : Google Scholar

11 

Walt AJ: Cysts and benign tumors of the liver. Surg Clin North Am. 57:449–464. 1977.PubMed/NCBI View Article : Google Scholar

12 

Tholomier C, Wang Y, Aleynikova O, Vanounou T and Pelletier JS: Biliary mucinous cystic neoplasm mimicking a hydatid cyst: A case report and literature review. BMC Gastroenterol. 19(103)2019.PubMed/NCBI View Article : Google Scholar

13 

Emre A, Serin KR, Ozden I, Tekant Y, Bilge O, Alper A, Güllüoğlu M and Güven K: Intrahepatic biliary cystic neoplasms: Surgical results of 9 patients and literature review. World J Gastroenterol. 17:361–365. 2011.PubMed/NCBI View Article : Google Scholar

14 

Davies W, Weiland L, Batts K and Nagorney DM: Intrahepatic biliary cystadenomas with and without mesenchymal stroma. HPB. 1:141–146. 1999.

15 

Simo KA, McKillop IH, Ahrens WA, Martinie JB, Iannitti DA and Sindram D: Invasive biliary mucinous cystic neoplasm: A review. HPB (Oxford). 14:725–740. 2012.PubMed/NCBI View Article : Google Scholar

16 

Erdogan D, Kloek J, Lamers WH, Offerhaus GJA, Busch ORC, Gouma DJ and Van Gulik TM: Mucinous cystadenomas in liver: Management and origin. Dig Surg. 27:19–23. 2010.PubMed/NCBI View Article : Google Scholar

17 

Zamboni G, Scarpa A, Bogina G, Iacono C, Bassi C, Talamini G, Sessa F, Capella C, Solcia E, Rickaert F, et al: Mucinous cystic tumors of the pancreas: Clinicopathological features, prognosis, and relationship to other mucinous cystic tumors. Am J Surg Pathol. 23:410–422. 1999.PubMed/NCBI View Article : Google Scholar

18 

Vanags A, Pavars M, Prieditis P, Strumfa I, Irmejs A and Gardovskis J: Biliary cystic tumours with mesenchymal stroma. Acta Chir Latv. 9:95–99. 2010.

19 

Mortelé KJ and Ros PR: Cystic focal liver lesions in the adult: Differential CT and MR imaging features. Radiographics. 21:895–910. 2001.PubMed/NCBI View Article : Google Scholar

20 

Soares KC, Arnaoutakis DJ, Kamel I, Anders R, Adams RB, Bauer TW and Pawlik TM: Cystic neoplasms of the liver: Biliary cystadenoma and cystadenocarcinoma. J Am Coll Surg. 218:119–128. 2014.PubMed/NCBI View Article : Google Scholar

21 

Kim JY, Kim SH, Eun HW, Lee MW, Lee JY, Han JK and Choi BI: Differentiation between biliary cystic neoplasms and simple cysts of the liver: Accuracy of CT. Am J Roentgenol. 195:1142–1148. 2010.PubMed/NCBI View Article : Google Scholar

22 

Borhani AA, Wiant A and Heller MT: Cystic hepatic lesions: A review and an algorithmic approach. Am J Roentgenol. 203:1192–1204. 2014.PubMed/NCBI View Article : Google Scholar

23 

Marrone G, Maggiore G, Carollo V, Sonzogni A and Luca A: Biliary cystadenoma with bile duct communication depicted on liver-specific contrast agent-enhanced MRI in a child. Pediatr Radiol. 41:121–124. 2011.PubMed/NCBI View Article : Google Scholar

24 

Läuffer JM, Baer HU, Maurer CA, Stoupis C, Zimmerman A and Büchler MW: Biliary cystadenocarcinoma of the liver: The need for complete resection. Eur J Cancer. 34:1845–1851. 1998.PubMed/NCBI View Article : Google Scholar

25 

Ohtsuka M, Shimizu H, Kato A, Yoshitomi H, Furukawa K, Tsuyuguchi T, Sakai Y, Yokosuka O and Miyazaki M: Intraductal papillary neoplasms of the bile duct. Int J Hepatol. 2014(459091)2014.PubMed/NCBI View Article : Google Scholar

26 

Grubor NM, Colovic RB, Atkinson HD and Micev MT: Giant biliary mucinous cystadenoma of the liver. Ann Hepatol. 12:979–983. 2013.PubMed/NCBI

27 

Limongelli P, Pai M, Damrah O, Lauretta A, Atijosan O, Habib N and Jiao LR: Cystic tumors of the biliary tract: A complete excision is crucial. Int Surg. 94:136–140. 2009.PubMed/NCBI

28 

Hazanaki K, Yoshizawa K and Mori H: Hepatic arterial infusion chemotherapy of cisplatin for biliary cystadenoma. Hepatogastrenterology. 46:462–464. 1999.PubMed/NCBI

29 

Zen Y, Pedica F, Patcha VR, Capelli P, Zamboni G, Casaril A, Quaglia A, Nakanuma Y, Heaton N and Portmann B: Mucinous cystic neoplasms of the liver: A clinicopathological study and comparison with intraductal papillary neoplasms of the bile duct. Mod Pathol. 24:1079–1089. 2011.PubMed/NCBI View Article : Google Scholar

30 

Kubota K, Nakanuma Y, Kondo F, Hachiya H, Miyazaki M, Nagino M, Yamamoto M, Isayama H, Tabata M, Kinoshita H, et al: Clinicopathological features and prognosis of mucin-producing bile duct tumor and mucinous cystic tumor of the liver: A multi-institutional study by the Japan Biliary Association. J Hepatobiliary Pancreat Sci. 21:176–185. 2014.PubMed/NCBI View Article : Google Scholar

31 

Ratti FA, Ferla F, Paganelli M, Cipriani FA, Aldrighetti LA and Ferla G: Biliary cystadenoma: Short-and long-term outcome after radical hepatic resection. Updates Surg. 64:13–18. 2012.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Paspala A, Machairas N, Damaskou V, Ntomi V, Kykalos S, Machairas A and Schizas D: A rare case of extrahepatic biliary mucinous cystic neoplasm in a middle‑aged woman: A case report. Mol Clin Oncol 15: 196, 2021.
APA
Paspala, A., Machairas, N., Damaskou, V., Ntomi, V., Kykalos, S., Machairas, A., & Schizas, D. (2021). A rare case of extrahepatic biliary mucinous cystic neoplasm in a middle‑aged woman: A case report. Molecular and Clinical Oncology, 15, 196. https://doi.org/10.3892/mco.2021.2358
MLA
Paspala, A., Machairas, N., Damaskou, V., Ntomi, V., Kykalos, S., Machairas, A., Schizas, D."A rare case of extrahepatic biliary mucinous cystic neoplasm in a middle‑aged woman: A case report". Molecular and Clinical Oncology 15.4 (2021): 196.
Chicago
Paspala, A., Machairas, N., Damaskou, V., Ntomi, V., Kykalos, S., Machairas, A., Schizas, D."A rare case of extrahepatic biliary mucinous cystic neoplasm in a middle‑aged woman: A case report". Molecular and Clinical Oncology 15, no. 4 (2021): 196. https://doi.org/10.3892/mco.2021.2358
Copy and paste a formatted citation
x
Spandidos Publications style
Paspala A, Machairas N, Damaskou V, Ntomi V, Kykalos S, Machairas A and Schizas D: A rare case of extrahepatic biliary mucinous cystic neoplasm in a middle‑aged woman: A case report. Mol Clin Oncol 15: 196, 2021.
APA
Paspala, A., Machairas, N., Damaskou, V., Ntomi, V., Kykalos, S., Machairas, A., & Schizas, D. (2021). A rare case of extrahepatic biliary mucinous cystic neoplasm in a middle‑aged woman: A case report. Molecular and Clinical Oncology, 15, 196. https://doi.org/10.3892/mco.2021.2358
MLA
Paspala, A., Machairas, N., Damaskou, V., Ntomi, V., Kykalos, S., Machairas, A., Schizas, D."A rare case of extrahepatic biliary mucinous cystic neoplasm in a middle‑aged woman: A case report". Molecular and Clinical Oncology 15.4 (2021): 196.
Chicago
Paspala, A., Machairas, N., Damaskou, V., Ntomi, V., Kykalos, S., Machairas, A., Schizas, D."A rare case of extrahepatic biliary mucinous cystic neoplasm in a middle‑aged woman: A case report". Molecular and Clinical Oncology 15, no. 4 (2021): 196. https://doi.org/10.3892/mco.2021.2358
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