Open Access

Fascin‑1 is associated with recurrence in solitary fibrous tumor/hemangiopericytoma

  • Authors:
    • Yumiko Yamamoto
    • Yoshihiro Hayashi
    • Hideyuki Sakaki
    • Ichiro Murakami
  • View Affiliations

  • Published online on: August 8, 2021     https://doi.org/10.3892/mco.2021.2361
  • Article Number: 199
  • Copyright: © Yamamoto et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Fascin‑1, an actin‑bundling protein, is associated with poor prognosis in patients with various types of human carcinoma. However, research is limited on the role of fascin‑1 in sarcoma. Solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) are rare sarcomas derived from the mesenchyme. Although the prognosis of SFT/HPC is generally favorable, fatalities are possible with repeated recurrence and distant metastasis. The current study included a total of 20 Japanese patients, who were diagnosed with SFT/HPC and underwent surgery at Kochi University Hospital from January 2000 to December 2019. The statistical relationship between recurrence and the following variables were examined: Sex, age of onset, tumor origin, tumor size, necrosis, mitosis ≥1/10 high power field (HPF; magnification, x400), Ki‑67 >5% and Fascin‑1. A significant association was determined between recurrence and necrosis, mitosis ≥1/10 HPF (magnification, x400), Ki‑67 >5%, and Fascin‑1 ≥‘strongly positive’ (P<0.05). The results demonstrated that Fascin‑1 immunostaining may be a highly effective and useful evaluation factor for predicting poor prognosis in patients with SFT/HPC, a fatal sarcoma of humans.
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October-2021
Volume 15 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Yamamoto Y, Hayashi Y, Sakaki H and Murakami I: Fascin‑1 is associated with recurrence in solitary fibrous tumor/hemangiopericytoma. Mol Clin Oncol 15: 199, 2021
APA
Yamamoto, Y., Hayashi, Y., Sakaki, H., & Murakami, I. (2021). Fascin‑1 is associated with recurrence in solitary fibrous tumor/hemangiopericytoma. Molecular and Clinical Oncology, 15, 199. https://doi.org/10.3892/mco.2021.2361
MLA
Yamamoto, Y., Hayashi, Y., Sakaki, H., Murakami, I."Fascin‑1 is associated with recurrence in solitary fibrous tumor/hemangiopericytoma". Molecular and Clinical Oncology 15.4 (2021): 199.
Chicago
Yamamoto, Y., Hayashi, Y., Sakaki, H., Murakami, I."Fascin‑1 is associated with recurrence in solitary fibrous tumor/hemangiopericytoma". Molecular and Clinical Oncology 15, no. 4 (2021): 199. https://doi.org/10.3892/mco.2021.2361