Open Access

Efficacy of adjuvant chemotherapy after complete resection of pulmonary metastasis from colorectal cancer

  • Authors:
    • Yuki Okazaki
    • Masatsune Shibutani
    • En Wang
    • Hisashi Nagahara
    • Tatsunari Fukuoka
    • Yasuhito Iseki
    • Kiyoshi Maeda
    • Kosei Hirakawa
    • Masaichi Ohira
  • View Affiliations

  • Published online on: August 8, 2021     https://doi.org/10.3892/mco.2021.2367
  • Article Number: 205
  • Copyright: © Okazaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The most effective treatment for pulmonary metastasis from colorectal cancer (CRC) is complete resection. However, as the recurrence rate after resection of the pulmonary metastases from CRC is high, postoperative adjuvant chemotherapy is often performed in clinical practice. The purpose of the present study was to evaluate the efficacy and safety of single‑agent adjuvant chemotherapy after resection of pulmonary metastasis from CRC. The medical records of 16 patients who underwent the first complete resection of pulmonary metastasis from CRC were retrospectively reviewed. A total of eight patients were treated with single‑agent adjuvant chemotherapy after resection of pulmonary metastasis, and oral fluoropyrimidines were selected in all regimens. As a result, the relapse‑free survival rate after resection of pulmonary metastasis in the group that received postoperative adjuvant chemotherapy was significantly improved in comparison with the group treated with surgery alone. In the subgroup analysis, patients who benefited from postoperative adjuvant chemotherapy in some high‑risk groups were selected, including patients with a high tumor stage or poor immunological status. In conclusion, single‑agent adjuvant chemotherapy after resection of pulmonary metastasis from CRC was effective for reducing the risk of recurrence and was safe to administer. In addition, certain risk factors may identify patients who would receive more benefit from postoperative adjuvant chemotherapy after resection of pulmonary metastasis from CRC.
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October-2021
Volume 15 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Okazaki Y, Shibutani M, Wang E, Nagahara H, Fukuoka T, Iseki Y, Maeda K, Hirakawa K and Ohira M: Efficacy of adjuvant chemotherapy after complete resection of pulmonary metastasis from colorectal cancer. Mol Clin Oncol 15: 205, 2021
APA
Okazaki, Y., Shibutani, M., Wang, E., Nagahara, H., Fukuoka, T., Iseki, Y. ... Ohira, M. (2021). Efficacy of adjuvant chemotherapy after complete resection of pulmonary metastasis from colorectal cancer. Molecular and Clinical Oncology, 15, 205. https://doi.org/10.3892/mco.2021.2367
MLA
Okazaki, Y., Shibutani, M., Wang, E., Nagahara, H., Fukuoka, T., Iseki, Y., Maeda, K., Hirakawa, K., Ohira, M."Efficacy of adjuvant chemotherapy after complete resection of pulmonary metastasis from colorectal cancer". Molecular and Clinical Oncology 15.4 (2021): 205.
Chicago
Okazaki, Y., Shibutani, M., Wang, E., Nagahara, H., Fukuoka, T., Iseki, Y., Maeda, K., Hirakawa, K., Ohira, M."Efficacy of adjuvant chemotherapy after complete resection of pulmonary metastasis from colorectal cancer". Molecular and Clinical Oncology 15, no. 4 (2021): 205. https://doi.org/10.3892/mco.2021.2367