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Re‑evaluating the clinical significance of serum p53 antibody levels in patients with oral cancer in Japanese clinical practice

  • Authors:
    • Shunsuke Gohara
    • Ryoji Yoshida
    • Kenta Kawahara
    • Junki Sakata
    • Hidetaka Arita
    • Hikaru Nakashima
    • Sho Kawaguchi
    • Yuka Nagao
    • Keisuke Yamana
    • Masashi Nagata
    • Akiyuki Hirosue
    • Akimitsu Hiraki
    • Hideki Nakayama
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto 860‑8556, Japan, Section of Oral Oncology, Department of Oral and Maxillofacial Surgery, Fukuoka Dental College, Fukuoka 814‑0193, Japan
    Copyright: © Gohara et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 209
    |
    Published online on: August 9, 2021
       https://doi.org/10.3892/mco.2021.2372
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Abstract

TP53 gene mutations can lead to mutant p53 protein accumulation in cancer cells, thereby inducing the production of serum antip53 antibodies (Ap53Ab) in patients with various types of cancer. The aim of the present study was to re‑evaluate the clinicopathological and prognostic significance of Ap53Ab using the Ap53Ab ELISA kit, approved by the Japanese Health Insurance System in 2007. Ap53Ab was measured as a tumor marker in 94 patients with oral squamous cell carcinoma (OSCC), by subjecting paraffin‑embedded sections obtained from biopsy specimens to immunohistochemical analysis to confirm p53 expression. The associations among Ap53Ab status, p53 expression and clinical significance in OSCC were examined. A total of 23% of the patients were Ap53Ab‑positive. Ap53Ab status was found to be significantly associated with p53 expression status in primary tumors (P=0.027), clinical T‑category, pathological N‑category and pathological stage (P=0.04, P=0.010 and P=0.013, respectively). Kaplan‑Meier curve analysis revealed that Ap53Ab status was significantly associated with poor disease‑free survival (DFS; P=0.043), and Cox regression analysis revealed that Ap53Ab status was a significant prognostic factor for DFS in patients with OSCC (hazard ratio=2.807; 95% confidence interval: 1.029‑7.160; P=0.044). These results suggested that Ap53Ab measurement may reflect the p53 mutation status and an aggressive malignant phenotype, and it may serve as a useful predictive marker candidate for OSCC in clinical practice.
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Copy and paste a formatted citation
Spandidos Publications style
Gohara S, Yoshida R, Kawahara K, Sakata J, Arita H, Nakashima H, Kawaguchi S, Nagao Y, Yamana K, Nagata M, Nagata M, et al: Re‑evaluating the clinical significance of serum p53 antibody levels in patients with oral cancer in Japanese clinical practice. Mol Clin Oncol 15: 209, 2021.
APA
Gohara, S., Yoshida, R., Kawahara, K., Sakata, J., Arita, H., Nakashima, H. ... Nakayama, H. (2021). Re‑evaluating the clinical significance of serum p53 antibody levels in patients with oral cancer in Japanese clinical practice. Molecular and Clinical Oncology, 15, 209. https://doi.org/10.3892/mco.2021.2372
MLA
Gohara, S., Yoshida, R., Kawahara, K., Sakata, J., Arita, H., Nakashima, H., Kawaguchi, S., Nagao, Y., Yamana, K., Nagata, M., Hirosue, A., Hiraki, A., Nakayama, H."Re‑evaluating the clinical significance of serum p53 antibody levels in patients with oral cancer in Japanese clinical practice". Molecular and Clinical Oncology 15.4 (2021): 209.
Chicago
Gohara, S., Yoshida, R., Kawahara, K., Sakata, J., Arita, H., Nakashima, H., Kawaguchi, S., Nagao, Y., Yamana, K., Nagata, M., Hirosue, A., Hiraki, A., Nakayama, H."Re‑evaluating the clinical significance of serum p53 antibody levels in patients with oral cancer in Japanese clinical practice". Molecular and Clinical Oncology 15, no. 4 (2021): 209. https://doi.org/10.3892/mco.2021.2372
Copy and paste a formatted citation
x
Spandidos Publications style
Gohara S, Yoshida R, Kawahara K, Sakata J, Arita H, Nakashima H, Kawaguchi S, Nagao Y, Yamana K, Nagata M, Nagata M, et al: Re‑evaluating the clinical significance of serum p53 antibody levels in patients with oral cancer in Japanese clinical practice. Mol Clin Oncol 15: 209, 2021.
APA
Gohara, S., Yoshida, R., Kawahara, K., Sakata, J., Arita, H., Nakashima, H. ... Nakayama, H. (2021). Re‑evaluating the clinical significance of serum p53 antibody levels in patients with oral cancer in Japanese clinical practice. Molecular and Clinical Oncology, 15, 209. https://doi.org/10.3892/mco.2021.2372
MLA
Gohara, S., Yoshida, R., Kawahara, K., Sakata, J., Arita, H., Nakashima, H., Kawaguchi, S., Nagao, Y., Yamana, K., Nagata, M., Hirosue, A., Hiraki, A., Nakayama, H."Re‑evaluating the clinical significance of serum p53 antibody levels in patients with oral cancer in Japanese clinical practice". Molecular and Clinical Oncology 15.4 (2021): 209.
Chicago
Gohara, S., Yoshida, R., Kawahara, K., Sakata, J., Arita, H., Nakashima, H., Kawaguchi, S., Nagao, Y., Yamana, K., Nagata, M., Hirosue, A., Hiraki, A., Nakayama, H."Re‑evaluating the clinical significance of serum p53 antibody levels in patients with oral cancer in Japanese clinical practice". Molecular and Clinical Oncology 15, no. 4 (2021): 209. https://doi.org/10.3892/mco.2021.2372
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