HER2‑amplified metastatic lung adenocarcinoma responds to fourth‑line pyrotinib therapy: A case report

  • Authors:
    • Kan Gong
    • Yi Yang
    • Huan Huang
    • Xunjie Kuang
    • Xueqin Yang
  • View Affiliations

  • Published online on: August 19, 2021     https://doi.org/10.3892/mco.2021.2375
  • Article Number: 213
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Abstract

Despite the success of anti‑HER2 therapy in patients with breast cancer with HER2 amplification or HER2 overexpression, the results of clinical trials on anti‑HER2 therapy for lung cancer have not been satisfactory. The aim of the present study was to report a case of a non‑smoker, female patient diagnosed with stage IIIA lung adenocarcinoma harboring HER2 amplification. The disease progressed despite surgery and multiple lines of chemotherapy, plus trastuzumab or lapatinib. The pan‑ErbB inhibitor pyrotinib (400 mg/day) was commenced as a fourth‑line regimen, and the patient achieved complete response with a time to progression (TTP) of 6 months. After the lung adenocarcinoma progressed, pyrotinib was continued, along with anlotinib and nivolumab. The patient achieved stable disease (SD) status with another 6 months of TTP. The overall survival of the patient was 28 months. Therefore, the present case suggests that the development of novel drugs may provide new and effective therapeutic regimens for lung cancer with HER2 amplification.
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October-2021
Volume 15 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Copy and paste a formatted citation
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Spandidos Publications style
Gong K, Yang Y, Huang H, Kuang X and Yang X: <em></em>HER2‑amplified metastatic lung adenocarcinoma responds to fourth‑line pyrotinib therapy: A case report. Mol Clin Oncol 15: 213, 2021
APA
Gong, K., Yang, Y., Huang, H., Kuang, X., & Yang, X. (2021). <em></em>HER2‑amplified metastatic lung adenocarcinoma responds to fourth‑line pyrotinib therapy: A case report. Molecular and Clinical Oncology, 15, 213. https://doi.org/10.3892/mco.2021.2375
MLA
Gong, K., Yang, Y., Huang, H., Kuang, X., Yang, X."<em></em>HER2‑amplified metastatic lung adenocarcinoma responds to fourth‑line pyrotinib therapy: A case report". Molecular and Clinical Oncology 15.4 (2021): 213.
Chicago
Gong, K., Yang, Y., Huang, H., Kuang, X., Yang, X."<em></em>HER2‑amplified metastatic lung adenocarcinoma responds to fourth‑line pyrotinib therapy: A case report". Molecular and Clinical Oncology 15, no. 4 (2021): 213. https://doi.org/10.3892/mco.2021.2375