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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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Case Report

HER2‑amplified metastatic lung adenocarcinoma responds to fourth‑line pyrotinib therapy: A case report

  • Authors:
    • Kan Gong
    • Yi Yang
    • Huan Huang
    • Xunjie Kuang
    • Xueqin Yang
  • View Affiliations / Copyright

    Affiliations: Cancer Center, Daping Hospital, Army Medical University, Chongqing 400042, P.R. China
  • Article Number: 213
    |
    Published online on: August 19, 2021
       https://doi.org/10.3892/mco.2021.2375
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Abstract

Despite the success of anti‑HER2 therapy in patients with breast cancer with HER2 amplification or HER2 overexpression, the results of clinical trials on anti‑HER2 therapy for lung cancer have not been satisfactory. The aim of the present study was to report a case of a non‑smoker, female patient diagnosed with stage IIIA lung adenocarcinoma harboring HER2 amplification. The disease progressed despite surgery and multiple lines of chemotherapy, plus trastuzumab or lapatinib. The pan‑ErbB inhibitor pyrotinib (400 mg/day) was commenced as a fourth‑line regimen, and the patient achieved complete response with a time to progression (TTP) of 6 months. After the lung adenocarcinoma progressed, pyrotinib was continued, along with anlotinib and nivolumab. The patient achieved stable disease (SD) status with another 6 months of TTP. The overall survival of the patient was 28 months. Therefore, the present case suggests that the development of novel drugs may provide new and effective therapeutic regimens for lung cancer with HER2 amplification.
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1 

Arcila ME, Chaft JE, Nafa K, Roy-Chowdhuri S, Lau C, Zaidinski M, Paik PK, Zakowski MF, Kris MG and Ladanyi M: Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas. Clin Cancer Res. 18:4910–4918. 2012.PubMed/NCBI View Article : Google Scholar

2 

Pillai RN, Behera M, Berry LD, Rossi MR, Kris MG, Johnson BE, Bunn PA, Ramalingam SS and Khuri FR: HER2 mutations in lung adenocarcinomas: A report from the lung cancer mutation consortium. Cancer. 123:4099–4105. 2017.PubMed/NCBI View Article : Google Scholar

3 

Li BT, Ross DS, Aisner DL, Chaft JE, Hsu M, Kako SL, Kris MG, Varella-Garcia M and Arcila ME: HER2 amplification and HER2 mutation are distinct molecular targets in lung cancers. J Thorac Oncol. 11:414–419. 2016.PubMed/NCBI View Article : Google Scholar

4 

Stephens P, Hunter C, Bignell G, Edkins S, Davies H, Teague J, Stevens C, O'Meara S, Smith R, Parker A, et al: Lung cancer: Intragenic ERBB2 kinase mutations in tumours. Nature. 431:525–526. 2004.PubMed/NCBI View Article : Google Scholar

5 

Robichaux JP, Elamin YY, Vijayan RSK, Nilsson MB, Hu L, He J, Zhang F, Pisegna M, Poteete A, Sun H, et al: Pan-cancer landscape and analysis of ERBB2 mutations identifies poziotinib as a clinically active inhibitor and enhancer of T-DM1 activity. Cancer Cell. 36:444–57.e7. 2019.PubMed/NCBI View Article : Google Scholar

6 

Wang Y, Jiang T, Qin Z, Jiang J, Wang Q, Yang S, Rivard C, Gao G, Ng TL, Tu MM, et al: HER2 exon20 insertions in non-small-cell lung cancer are sensitive to the irreversible pan-HER receptor tyrosine kinase inhibitor pyrotinib. Ann Oncol. 30:447–455. 2019.PubMed/NCBI View Article : Google Scholar

7 

Peters S, Curioni-Fontecedro A, Nechushtan H, Shih JY, Liao WY, Gautschi O, Spataro V, Unk M, Yang JCH, Lorence RM, et al: Activity of afatinib in heavily pretreated patients with ERBB2 mutation-positive advanced NSCLC: Findings from a global named patient use program. J Thorac Oncol. 13:1897–1905. 2018.PubMed/NCBI View Article : Google Scholar

8 

Oh DY and Bang YJ: HER2-targeted therapies-a role beyond breast cancer. Nat Rev Clin Oncol. 17:33–48. 2020.PubMed/NCBI View Article : Google Scholar

9 

Jeong Y, Hellyer JA, Stehr H, Hoang NT, Niu X, Das M, Padda SK, Ramchandran K, Neal JW, Wakelee H and Diehn M: Role of KEAP1/NFE2L2 mutations in the chemotherapeutic response of patients with non-small cell lung cancer. Clin Cancer Res. 26:274–281. 2020.PubMed/NCBI View Article : Google Scholar

10 

Yang LZ, Lei CC, Zhao YP, Sun HW, Yu QH, Yang EJ and Zhan X: MicroRNA-34c-3p target inhibiting NOTCH1 suppresses chemosensitivity and metastasis of non-small cell lung cancer. J Int Med Res. 48(300060520904847)2020.PubMed/NCBI View Article : Google Scholar

11 

Ma F, Li Q, Chen S, Zhu W, Fan Y, Wang J, Luo Y, Xing P, Lan B, Li M, et al: Phase I study and biomarker analysis of pyrotinib, novel irreversible Pan-ErbB receptor tyrosine kinase inhibitor, in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer. J Clin Oncol. 35:3105–3112. 2017.PubMed/NCBI View Article : Google Scholar

12 

Blair HA: Pyrotinib: First global approval. Drugs. 78:1751–1755. 2018.PubMed/NCBI View Article : Google Scholar

13 

Gourd E: Pyrotinib versus lapatinib in HER2-positive breast cancer. Lancet Oncol. 20(e562)2019.PubMed/NCBI View Article : Google Scholar

14 

Ma F, Ouyang Q, Li W, Jiang Z, Tong Z, Liu Y, Li H, Yu S, Feng J, Wang S, et al: Pyrotinib or lapatinib combined with capecitabine in HER2-positive metastatic breast cancer with prior taxanes, anthracyclines, and/or trastuzumab: A randomized, phase II study. J Clin Oncol. 37:2610–2619. 2019.PubMed/NCBI View Article : Google Scholar

15 

Choudhury NJ, Campanile A, Antic T, Yap KL, Fitzpatrick CA, Wade JL III, Karrison T, Stadler WM, Nakamura Y and O'Donnell PH: Afatinib activity in platinum-refractory metastatic urothelial carcinoma in patients with ERBB alterations. J Clin Oncol. 34:2165–2171. 2016.PubMed/NCBI View Article : Google Scholar

16 

Cancer Genome Atlas Research Network. Comprehensive molecular profiling of lung adenocarcinoma. Nature. 511:543–550. 2014.PubMed/NCBI View Article : Google Scholar

17 

Langer CJ, Stephenson P, Thor A, Vangel M and Johnson DH: Eastern Cooperative Oncology Group Study 2598. Trastuzumab in the treatment of advanced non-small-cell lung cancer: is there a role? focus on eastern cooperative oncology group study 2598. J Clin Oncol. 22:1180–1187. 2004.PubMed/NCBI View Article : Google Scholar

18 

Gatzemeier U, Groth G, Butts C, Van Zandwijk N, Shepherd F, Ardizzoni A, Barton C, Ghahramani P and Hirsh V: Randomized phase II trial of gemcitabine-cisplatin with or without trastuzumab in HER2-positive non-small-cell lung cancer. Ann Oncol. 15:19–27. 2004.PubMed/NCBI View Article : Google Scholar

19 

Hainsworth JD, Meric-Bernstam F, Swanton C, Hurwitz H, Spigel DR, Sweeney C, Burris H, Bose R, Yoo B, Stein A, et al: Targeted therapy for advanced solid tumors on the basis of molecular profiles: Results from mypathway, an open-label, phase IIa multiple basket study. J Clin Oncol. 36:536–542. 2018.PubMed/NCBI View Article : Google Scholar

20 

Hotta K, Aoe K, Kozuki T, Ohashi K, Ninomiya K, Ichihara E, Kubo T, Ninomiya T, Chikamori K, Harada D, et al: A phase II study of trastuzumab emtansine in HER2-positive non-small cell lung cancer. J Thorac Oncol. 13:273–279. 2018.PubMed/NCBI View Article : Google Scholar

21 

Peters S, Stahel R, Bubendorf L, Bonomi P, Villegas A, Kowalski DM, Baik CS, Isla D, De Castro Carpeno J, Garrido P, et al: Trastuzumab emtansine (T-DM1) in patients with previously treated HER2-overexpressing metastatic non-small cell lung cancer: Efficacy, safety, and biomarkers. Clin Cancer Res. 25:64–72. 2019.PubMed/NCBI View Article : Google Scholar

22 

Kris MG, Camidge DR, Giaccone G, Hida T, Li BT, O'Connell J, Taylor I, Zhang H, Arcila ME, Goldberg Z and Jänne PA: Targeting HER2 aberrations as actionable drivers in lung cancers: Phase II trial of the pan-HER tyrosine kinase inhibitor dacomitinib in patients with HER2-mutant or amplified tumors. Ann Oncol. 26:1421–1427. 2015.PubMed/NCBI View Article : Google Scholar

23 

Roskoski R Jr: Small molecule inhibitors targeting the EGFR/ErbB family of protein-tyrosine kinases in human cancers. Pharmacol Res. 139:395–411. 2019.PubMed/NCBI View Article : Google Scholar

24 

Labbé C, Cabanero M, Korpanty GJ, Tomasini P, Doherty MK, Mascaux C, Jao K, Pitcher B, Wang R, Pintilie M, et al: Prognostic and predictive effects of TP53 co-mutation in patients with EGFR-mutated non-small cell lung cancer (NSCLC). Lung Cancer. 111:23–29. 2017.PubMed/NCBI View Article : Google Scholar

25 

Hou H, Qin K, Liang Y, Zhang C, Liu D, Jiang H, Liu K, Zhu J, Lv H, Li T and Zhang X: Concurrent TP53 mutations predict poor outcomes of EGFR-TKI treatments in Chinese patients with advanced NSCLC. Cancer Manag Res. 11:5665–5675. 2019.PubMed/NCBI View Article : Google Scholar

26 

Hellyer JA, Stehr H, Das M, Padda SK, Ramchandran K, Neal JW, Diehn M and Wakelee HA: Impact of KEAP1/NFE2L2/CUL3 mutations on duration of response to EGFR tyrosine kinase inhibitors in EGFR mutated non-small cell lung cancer. Lung Cancer. 134:42–45. 2019.PubMed/NCBI View Article : Google Scholar

27 

Xuhong JC, Qi XW, Zhang Y and Jiang J: Mechanism, safety and efficacy of three tyrosine kinase inhibitors lapatinib, neratinib and pyrotinib in HER2-positive breast cancer. Am J Cancer Res. 9:2103–2119. 2019.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gong K, Yang Y, Huang H, Kuang X and Yang X: <em></em>HER2‑amplified metastatic lung adenocarcinoma responds to fourth‑line pyrotinib therapy: A case report. Mol Clin Oncol 15: 213, 2021.
APA
Gong, K., Yang, Y., Huang, H., Kuang, X., & Yang, X. (2021). <em></em>HER2‑amplified metastatic lung adenocarcinoma responds to fourth‑line pyrotinib therapy: A case report. Molecular and Clinical Oncology, 15, 213. https://doi.org/10.3892/mco.2021.2375
MLA
Gong, K., Yang, Y., Huang, H., Kuang, X., Yang, X."<em></em>HER2‑amplified metastatic lung adenocarcinoma responds to fourth‑line pyrotinib therapy: A case report". Molecular and Clinical Oncology 15.4 (2021): 213.
Chicago
Gong, K., Yang, Y., Huang, H., Kuang, X., Yang, X."<em></em>HER2‑amplified metastatic lung adenocarcinoma responds to fourth‑line pyrotinib therapy: A case report". Molecular and Clinical Oncology 15, no. 4 (2021): 213. https://doi.org/10.3892/mco.2021.2375
Copy and paste a formatted citation
x
Spandidos Publications style
Gong K, Yang Y, Huang H, Kuang X and Yang X: <em></em>HER2‑amplified metastatic lung adenocarcinoma responds to fourth‑line pyrotinib therapy: A case report. Mol Clin Oncol 15: 213, 2021.
APA
Gong, K., Yang, Y., Huang, H., Kuang, X., & Yang, X. (2021). <em></em>HER2‑amplified metastatic lung adenocarcinoma responds to fourth‑line pyrotinib therapy: A case report. Molecular and Clinical Oncology, 15, 213. https://doi.org/10.3892/mco.2021.2375
MLA
Gong, K., Yang, Y., Huang, H., Kuang, X., Yang, X."<em></em>HER2‑amplified metastatic lung adenocarcinoma responds to fourth‑line pyrotinib therapy: A case report". Molecular and Clinical Oncology 15.4 (2021): 213.
Chicago
Gong, K., Yang, Y., Huang, H., Kuang, X., Yang, X."<em></em>HER2‑amplified metastatic lung adenocarcinoma responds to fourth‑line pyrotinib therapy: A case report". Molecular and Clinical Oncology 15, no. 4 (2021): 213. https://doi.org/10.3892/mco.2021.2375
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