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Concurrent use of nivolumab and radiotherapy for patients with metastatic non‑small cell lung cancer and renal cell carcinoma with oligometastatic disease progression on nivolumab

  • Authors:
    • Jawaher Ansari
    • Ashraf Farrag
    • Arwa Ali
    • Mai Abdelgelil
    • Esam Murshid
    • Abdulaziz Alhamad
    • Muhammad Ali
    • Hidayath Ansari
    • Syed Hussain
    • John Glaholm
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Prince Sultan Military Medical City, Riyadh 12233, Saudi Arabia, Department of Imaging, Cleveland Clinic Abu Dhabi, Abu Dhabi 112412, United Arab Emirates, Department of Oncology and Metabolism, University of Sheffield, Sheffield S10 2RX, UK, Department of Oncology, Royal Marsden Hospital, London SW3 6JJ, UK
    Copyright: © Ansari et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 214
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    Published online on: August 23, 2021
       https://doi.org/10.3892/mco.2021.2376
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Abstract

Checkpoint inhibitors (CPIs), such as nivolumab, have transformed the treatment paradigm for patients with metastatic non‑small cell lung cancer (mNSCLC) and metastatic renal cell carcinoma (mRCC). The combination of CPIs and radiotherapy (RT) constitutes a multimodal treatment approach that may work synergistically and facilitate augmented systemic responses. The aim of the present retrospective study was to assess the efficacy and safety of continuation of nivolumab treatment with the addition of RT in patients with mNSCLC and mRCC who develop oligometastatic disease progression on single‑agent nivolumab. All patients with mNSCLC and mRCC who received nivolumab at the Department of Oncology, Prince Sultan Military Medical City (Riyadh, Saudi Arabia) between November 2016 and April 2018 were identified. The records of patients who developed oligometastatic disease progression during nivolumab treatment and were subsequently treated with RT, with nivolumab continued beyond disease progression, were retrospectively reviewed. Details of RT, clinical outcomes and toxicity data were collected. Of the 96 patients who received nivolumab, 22 received multiple courses of RT. A total of 39 sites were irradiated: Bone (n=15), lung (n=9), brain (n=8), adrenal gland (n=2), renal bed (n=2), skin (n=1), ethmoid sinus (n=1) and scalp (n=1). Partial response and complete response were noted at 25 (64%) and 3 (8%) sites, respectively. Stable disease was noted at 6 sites (15%) and disease progression was noted at 5 sites (13%). The median time on nivolumab from the date of the first fraction of RT was 4.5 months (range, 1.5‑29 months) for patients with mNSCLC and 5 months (range, 1‑38.5 months) for patients with mRCC. No patients developed grade 3‑4 toxicities. Grade 2 pneumonitis was noted in 3 patients receiving lung RT. The addition of RT appeared to initiate a response and prolong the duration of nivolumab treatment. Therefore, the combination of nivolumab and RT was found to be well tolerated, with response rates exceeding those in published studies of nivolumab monotherapy.
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Copy and paste a formatted citation
Spandidos Publications style
Ansari J, Farrag A, Ali A, Abdelgelil M, Murshid E, Alhamad A, Ali M, Ansari H, Hussain S, Glaholm J, Glaholm J, et al: Concurrent use of nivolumab and radiotherapy for patients with metastatic non‑small cell lung cancer and renal cell carcinoma with oligometastatic disease progression on nivolumab. Mol Clin Oncol 15: 214, 2021.
APA
Ansari, J., Farrag, A., Ali, A., Abdelgelil, M., Murshid, E., Alhamad, A. ... Glaholm, J. (2021). Concurrent use of nivolumab and radiotherapy for patients with metastatic non‑small cell lung cancer and renal cell carcinoma with oligometastatic disease progression on nivolumab. Molecular and Clinical Oncology, 15, 214. https://doi.org/10.3892/mco.2021.2376
MLA
Ansari, J., Farrag, A., Ali, A., Abdelgelil, M., Murshid, E., Alhamad, A., Ali, M., Ansari, H., Hussain, S., Glaholm, J."Concurrent use of nivolumab and radiotherapy for patients with metastatic non‑small cell lung cancer and renal cell carcinoma with oligometastatic disease progression on nivolumab". Molecular and Clinical Oncology 15.4 (2021): 214.
Chicago
Ansari, J., Farrag, A., Ali, A., Abdelgelil, M., Murshid, E., Alhamad, A., Ali, M., Ansari, H., Hussain, S., Glaholm, J."Concurrent use of nivolumab and radiotherapy for patients with metastatic non‑small cell lung cancer and renal cell carcinoma with oligometastatic disease progression on nivolumab". Molecular and Clinical Oncology 15, no. 4 (2021): 214. https://doi.org/10.3892/mco.2021.2376
Copy and paste a formatted citation
x
Spandidos Publications style
Ansari J, Farrag A, Ali A, Abdelgelil M, Murshid E, Alhamad A, Ali M, Ansari H, Hussain S, Glaholm J, Glaholm J, et al: Concurrent use of nivolumab and radiotherapy for patients with metastatic non‑small cell lung cancer and renal cell carcinoma with oligometastatic disease progression on nivolumab. Mol Clin Oncol 15: 214, 2021.
APA
Ansari, J., Farrag, A., Ali, A., Abdelgelil, M., Murshid, E., Alhamad, A. ... Glaholm, J. (2021). Concurrent use of nivolumab and radiotherapy for patients with metastatic non‑small cell lung cancer and renal cell carcinoma with oligometastatic disease progression on nivolumab. Molecular and Clinical Oncology, 15, 214. https://doi.org/10.3892/mco.2021.2376
MLA
Ansari, J., Farrag, A., Ali, A., Abdelgelil, M., Murshid, E., Alhamad, A., Ali, M., Ansari, H., Hussain, S., Glaholm, J."Concurrent use of nivolumab and radiotherapy for patients with metastatic non‑small cell lung cancer and renal cell carcinoma with oligometastatic disease progression on nivolumab". Molecular and Clinical Oncology 15.4 (2021): 214.
Chicago
Ansari, J., Farrag, A., Ali, A., Abdelgelil, M., Murshid, E., Alhamad, A., Ali, M., Ansari, H., Hussain, S., Glaholm, J."Concurrent use of nivolumab and radiotherapy for patients with metastatic non‑small cell lung cancer and renal cell carcinoma with oligometastatic disease progression on nivolumab". Molecular and Clinical Oncology 15, no. 4 (2021): 214. https://doi.org/10.3892/mco.2021.2376
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