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Enhanced liver fibrosis score as a predictive marker for hepatocellular carcinoma development after hepatitis C virus eradication

  • Authors:
    • Toshihiro Kawaguchi
    • Tatsuya Ide
    • Keisuke Amano
    • Teruko Arinaga‑Hino
    • Reiichiro Kuwahara
    • Tomoya Sano
    • Shirachi Miki
    • Naofumi Ono
    • Takuji Torimura
  • View Affiliations / Copyright

    Affiliations: Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830‑0011, Japan, Chikugo City Hospital, Chikugo, Fukuoka 833‑0041, Japan, Yame General Hospital, Yame, Fukuoka 834‑0034, Japan
    Copyright: © Kawaguchi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 215
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    Published online on: August 23, 2021
       https://doi.org/10.3892/mco.2021.2377
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Abstract

Advanced liver fibrosis is the most important risk factor for hepatocellular carcinoma (HCC) development after achieving sustained virological response (SVR) by direct‑acting antiviral (DAA) treatment in patients with chronic hepatitis C. Wisteria floribunda agglutinin‑positive Mac‑2‑binding protein (M2BPGi), enhanced liver fibrosis (ELF) score, type IV collagen and fibrosis‑4 (FIB‑4) index have been reported as non‑invasive biomarkers for liver fibrosis. In the present study, the possibility of using fibrosis biomarkers and other parameters to predict the development of HCC was evaluated. A total of 743 patients infected with hepatitis C virus who achieved SVR by using DAA were retrospectively enrolled. Of these, 122 patients whose blood samples were stored were selected. The aforementioned four fibrosis biomarkers were analyzed at baseline, at the end of treatment (EOT) and at post‑treatment week 24 (PTW24). Tumor markers and laboratory tests were also analyzed. The baseline/EOT/PTW24 values for each fibrosis biomarker were as follows: ELF score: 11.5±1.2/10.8±1.1/10.4±1.0; type IV collagen: 213±85/190±67/174±55 ng/ml; M2BPGi: 4.8±3.5/2.7±2.0/2.2±1.8; and FIB‑4 index: 5.31±3.82/4.36±2.79/4.24±3.09. Of the 122 patients, 23 developed HCC. A high baseline ELF score (P=0.0264), PTW24 ELF score (P=0.0003), PTW24 α‑fetoprotein level (P=0.0133), baseline FIB‑4 index (P=0.0451) and low baseline prothrombin time (P=0.0455) were risk factors for HCC development based on univariate analyses. Based on the multivariate analysis, a high PTW24 ELF score was the only risk factor for HCC development (P=0.0035). The ELF score after DAA therapy was strongly associated with HCC development; therefore, it may be a useful marker for predicting HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Kawaguchi T, Ide T, Amano K, Arinaga‑Hino T, Kuwahara R, Sano T, Miki S, Ono N and Torimura T: Enhanced liver fibrosis score as a predictive marker for hepatocellular carcinoma development after hepatitis C virus eradication. Mol Clin Oncol 15: 215, 2021.
APA
Kawaguchi, T., Ide, T., Amano, K., Arinaga‑Hino, T., Kuwahara, R., Sano, T. ... Torimura, T. (2021). Enhanced liver fibrosis score as a predictive marker for hepatocellular carcinoma development after hepatitis C virus eradication. Molecular and Clinical Oncology, 15, 215. https://doi.org/10.3892/mco.2021.2377
MLA
Kawaguchi, T., Ide, T., Amano, K., Arinaga‑Hino, T., Kuwahara, R., Sano, T., Miki, S., Ono, N., Torimura, T."Enhanced liver fibrosis score as a predictive marker for hepatocellular carcinoma development after hepatitis C virus eradication". Molecular and Clinical Oncology 15.4 (2021): 215.
Chicago
Kawaguchi, T., Ide, T., Amano, K., Arinaga‑Hino, T., Kuwahara, R., Sano, T., Miki, S., Ono, N., Torimura, T."Enhanced liver fibrosis score as a predictive marker for hepatocellular carcinoma development after hepatitis C virus eradication". Molecular and Clinical Oncology 15, no. 4 (2021): 215. https://doi.org/10.3892/mco.2021.2377
Copy and paste a formatted citation
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Spandidos Publications style
Kawaguchi T, Ide T, Amano K, Arinaga‑Hino T, Kuwahara R, Sano T, Miki S, Ono N and Torimura T: Enhanced liver fibrosis score as a predictive marker for hepatocellular carcinoma development after hepatitis C virus eradication. Mol Clin Oncol 15: 215, 2021.
APA
Kawaguchi, T., Ide, T., Amano, K., Arinaga‑Hino, T., Kuwahara, R., Sano, T. ... Torimura, T. (2021). Enhanced liver fibrosis score as a predictive marker for hepatocellular carcinoma development after hepatitis C virus eradication. Molecular and Clinical Oncology, 15, 215. https://doi.org/10.3892/mco.2021.2377
MLA
Kawaguchi, T., Ide, T., Amano, K., Arinaga‑Hino, T., Kuwahara, R., Sano, T., Miki, S., Ono, N., Torimura, T."Enhanced liver fibrosis score as a predictive marker for hepatocellular carcinoma development after hepatitis C virus eradication". Molecular and Clinical Oncology 15.4 (2021): 215.
Chicago
Kawaguchi, T., Ide, T., Amano, K., Arinaga‑Hino, T., Kuwahara, R., Sano, T., Miki, S., Ono, N., Torimura, T."Enhanced liver fibrosis score as a predictive marker for hepatocellular carcinoma development after hepatitis C virus eradication". Molecular and Clinical Oncology 15, no. 4 (2021): 215. https://doi.org/10.3892/mco.2021.2377
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