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Neutrophil‑to‑lymphocyte ratio is associated with sensitivity to platinum‑based chemotherapy and prognosis in patients with advanced serous ovarian carcinoma

  • Authors:
    • Takeshi Fukuda
    • Masaru Kawanishi
    • Yuichiro Awazu
    • Shigenori Nanno
    • Masahiro Shimomura
    • Yuta Inoue
    • Hiroaki Matsubara
    • Makoto Yamauchi
    • Mari Kasai
    • Yasunori Hashiguchi
    • Tomoyuki Ichimura
    • Tomoyo Yasui
    • Toshiyuki Sumi
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka 545‑8585, Japan
    Copyright: © Fukuda et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 217
    |
    Published online on: August 25, 2021
       https://doi.org/10.3892/mco.2021.2381
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Abstract

The role of the neutrophil‑to‑lymphocyte ratio (NLR) in predicting sensitivity to chemotherapy and prognosis has attracted great interest in several types of cancer. In the present study, the correlation between pre‑chemotherapy NLR and sensitivity to platinum‑based chemotherapy and prognosis in patients with advanced serous ovarian carcinoma was examined by retrospectively reviewing the medical records of 50 patients with stage III‑IV serous ovarian carcinoma from 2005 to 2012. Patients were divided into high‑NLR (32 patients) and low‑NLR (18 patients) groups according to a cutoff value of 2.47. This cutoff was calculated using a receiver operating characteristic (ROC) curve that demonstrated 84% specificity and 60% sensitivity. Patient characteristics, sensitivity to platinum‑based chemotherapy and prognosis were subsequently compared. The results revealed no significant difference in patient characteristics between the two groups. In the low‑NLR group, 14 of 18 patients (77.8%) were sensitive to platinum‑based chemotherapy, whereas 11 of 32 were sensitive in the high‑NLR group (34.4%) (P=0.007). Overall and disease‑free survival (DFS) were significantly longer in the low‑NLR than in the high‑NLR group (P=0.013 and P=0.043, respectively). The current results suggested that pre‑chemotherapeutical NLR may serve as a biomarker of sensitivity to platinum‑based chemotherapy and prognosis in patients with advanced serous ovarian carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Fukuda T, Kawanishi M, Awazu Y, Nanno S, Shimomura M, Inoue Y, Matsubara H, Yamauchi M, Kasai M, Hashiguchi Y, Hashiguchi Y, et al: Neutrophil‑to‑lymphocyte ratio is associated with sensitivity to platinum‑based chemotherapy and prognosis in patients with advanced serous ovarian carcinoma. Mol Clin Oncol 15: 217, 2021.
APA
Fukuda, T., Kawanishi, M., Awazu, Y., Nanno, S., Shimomura, M., Inoue, Y. ... Sumi, T. (2021). Neutrophil‑to‑lymphocyte ratio is associated with sensitivity to platinum‑based chemotherapy and prognosis in patients with advanced serous ovarian carcinoma. Molecular and Clinical Oncology, 15, 217. https://doi.org/10.3892/mco.2021.2381
MLA
Fukuda, T., Kawanishi, M., Awazu, Y., Nanno, S., Shimomura, M., Inoue, Y., Matsubara, H., Yamauchi, M., Kasai, M., Hashiguchi, Y., Ichimura, T., Yasui, T., Sumi, T."Neutrophil‑to‑lymphocyte ratio is associated with sensitivity to platinum‑based chemotherapy and prognosis in patients with advanced serous ovarian carcinoma". Molecular and Clinical Oncology 15.4 (2021): 217.
Chicago
Fukuda, T., Kawanishi, M., Awazu, Y., Nanno, S., Shimomura, M., Inoue, Y., Matsubara, H., Yamauchi, M., Kasai, M., Hashiguchi, Y., Ichimura, T., Yasui, T., Sumi, T."Neutrophil‑to‑lymphocyte ratio is associated with sensitivity to platinum‑based chemotherapy and prognosis in patients with advanced serous ovarian carcinoma". Molecular and Clinical Oncology 15, no. 4 (2021): 217. https://doi.org/10.3892/mco.2021.2381
Copy and paste a formatted citation
x
Spandidos Publications style
Fukuda T, Kawanishi M, Awazu Y, Nanno S, Shimomura M, Inoue Y, Matsubara H, Yamauchi M, Kasai M, Hashiguchi Y, Hashiguchi Y, et al: Neutrophil‑to‑lymphocyte ratio is associated with sensitivity to platinum‑based chemotherapy and prognosis in patients with advanced serous ovarian carcinoma. Mol Clin Oncol 15: 217, 2021.
APA
Fukuda, T., Kawanishi, M., Awazu, Y., Nanno, S., Shimomura, M., Inoue, Y. ... Sumi, T. (2021). Neutrophil‑to‑lymphocyte ratio is associated with sensitivity to platinum‑based chemotherapy and prognosis in patients with advanced serous ovarian carcinoma. Molecular and Clinical Oncology, 15, 217. https://doi.org/10.3892/mco.2021.2381
MLA
Fukuda, T., Kawanishi, M., Awazu, Y., Nanno, S., Shimomura, M., Inoue, Y., Matsubara, H., Yamauchi, M., Kasai, M., Hashiguchi, Y., Ichimura, T., Yasui, T., Sumi, T."Neutrophil‑to‑lymphocyte ratio is associated with sensitivity to platinum‑based chemotherapy and prognosis in patients with advanced serous ovarian carcinoma". Molecular and Clinical Oncology 15.4 (2021): 217.
Chicago
Fukuda, T., Kawanishi, M., Awazu, Y., Nanno, S., Shimomura, M., Inoue, Y., Matsubara, H., Yamauchi, M., Kasai, M., Hashiguchi, Y., Ichimura, T., Yasui, T., Sumi, T."Neutrophil‑to‑lymphocyte ratio is associated with sensitivity to platinum‑based chemotherapy and prognosis in patients with advanced serous ovarian carcinoma". Molecular and Clinical Oncology 15, no. 4 (2021): 217. https://doi.org/10.3892/mco.2021.2381
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