Prognostic factors for bone metastases from head and neck squamous cell carcinoma: A case series of 97 patients

Sakisuka,Takahisa; Kashiwagi,Nobuo; Doi,Hiroshi; Takahashi,Hiroto; Arisawa,Atsuko; Matsuo,Chisato; Masuda,Yu; Inohara,Hidenori; Sato,Kazuaki; Outani,Hidetatsu; Ishii,Kazunari; Tomiyama,Noriyuki

doi:10.3892/mco.2021.2408

Prognostic factors for bone metastases from head and neck squamous cell carcinoma: A case series of 97 patients

Authors:
- Takahisa Sakisuka
- Nobuo Kashiwagi
- Hiroshi Doi
- Hiroto Takahashi
- Atsuko Arisawa
- Chisato Matsuo
- Yu Masuda
- Hidenori Inohara
- Kazuaki Sato
- Hidetatsu Outani
- Kazunari Ishii
- Noriyuki Tomiyama
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Affiliations: Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine, Suita, Osaka 565‑0871, Japan, Department of Future Diagnostic Radiology, Osaka University Graduate School of Medicine, Suita, Osaka 565‑0871, Japan, Department of Radiation Oncology, Kindai University Faculty of Medicine, Osakasayama, Osaka 589‑8511, Japan, Center for Twin Research, Osaka University Graduate School of Medicine, Suita, Osaka 565‑0871, Japan, Department of Otorhinolaryngology‑Head and Neck Surgery, Osaka University Graduate School of Medicine, Suita, Osaka 565‑0871, Japan, Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka 565‑0871, Japan, Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka 565‑0871, Japan, Department of Radiology, Kindai University Faculty of Medicine, Osakasayama, Osaka 589‑8511, Japan
Published online on: September 27, 2021 https://doi.org/10.3892/mco.2021.2408
Article Number: 246

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Abstract

Although bone is the second‑most frequent site of distant metastases of head and neck squamous cell carcinoma (HNSCC), variable prognostic factors in patients with bone metastases from HNSCC have not been fully investigated. The aim of the present study was to assess the prognostic factors affecting overall survival (OS) in these patients. The medical records of 97 patients at two institutions who developed bone metastases from HNSCC between January 2010 and December 2020 were retrospectively reviewed. A multivariate analysis using a Cox proportional hazards model was performed to identify potential clinical predictive factors for longer OS. The median OS was 7 months, and the 1‑ and 2‑year OS rates for all patients were 35.4 and 19.2%, respectively. The independent predictive factors for longer OS were single bone metastasis, good performance status and administration of systemic chemotherapy. The median OS with each predictor was 10, 10 and 10.5 months, respectively. In a selected group of patients with these three factors, the OS was 14.5 months. In conclusion, single bone metastasis, a good performance status and systemic chemotherapy were independent predictors of longer OS in patients with HNSCC, but their contributions were limited.

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