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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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December-2021 Volume 15 Issue 6

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Case Report Open Access

Utility of X‑ray and indocyanine green fluorescence imaging in detecting hepatocellular carcinoma dissemination on laparoscopic surgery: A case report

  • Authors:
    • Shu Sasaki
    • Makoto Takahashi
    • Tatsuya Hayashi
    • Yasuhiro Morita
    • Shin Namiki
    • Shingo Itagaki
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Tokyo Metropolitan Tama Medical Center, Fuchu‑shi, Tokyo 183‑8524, Japan, Department of Gastroenterology and Hepatology, Tokyo Metropolitan Tama Medical Center, Fuchu‑shi, Tokyo 183‑8524, Japan, Department of Pathology, Tokyo Metropolitan Tama Medical Center, Fuchu‑shi, Tokyo 183‑8524, Japan
    Copyright: © Sasaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 259
    |
    Published online on: October 19, 2021
       https://doi.org/10.3892/mco.2021.2421
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Abstract

Indocyanine green (ICG) fluorescence imaging is useful for the intraoperative detection of the peritoneal dissemination of hepatocellular carcinoma (HCC). However, in laparoscopic surgery, disseminations cannot be accurately identified unless the camera lens is positioned close to the lesion. The present study describes a case of HCC dissemination in which the lesions were accurately identified by combining intraoperative fluoroscopy with ICG fluorescence imaging. A 76‑year‑old male was diagnosed with HCC dissemination. Computed tomography revealed a 9‑mm disseminated nodule near the gallbladder. Although transarterial chemoembolization had also been used to treat this lesion, chemoembolization was technically difficult to perform. Therefore, a coil was placed around the lesion to serve as an intraoperative landmark for later laparoscopic resection. Given the potential difficulty of detecting the lesion during laparoscopic surgery, ICG fluorescence imaging was used to determine the approximate location of the dissemination. The lesion exhibited strong fluorescence, which facilitated its complete resection.
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1 

Satou S, Ishizawa T, Masuda K, Kaneko J, Aoki T, Sakamoto Y, Hasegawa K, Sugawara Y and Kokudo N: Indocyanine green fluorescent imaging for detecting extrahepatic metastasis of hepatocellular carcinoma. J Gastroenterol. 48:1136–1143. 2013.PubMed/NCBI View Article : Google Scholar

2 

Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC, Santoro A, Raoul JL, Forner A, et al: Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 359:378–390. 2008.PubMed/NCBI View Article : Google Scholar

3 

Cheng AL, Kang YK, Chen Z, Tsao CJ, Qin S, Kim JS, Luo R, Feng J, Ye S, Yang TS, et al: Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 10:25–34. 2009.PubMed/NCBI View Article : Google Scholar

4 

Takemura N, Hasegawa K, Aoki T, Sakamoto Y, Sugawara Y, Makuuchi M and Kokudo N: Surgical resection of peritoneal or thoracoabdominal wall implants from hepatocellular carcinoma. Br J Surg. 101:1017–1022. 2014.PubMed/NCBI View Article : Google Scholar

5 

Sugie T, Kinoshita T, Masuda N, Sawada T, Yamauchi A, Kuroi K, Taguchi T, Bando H, Yamashiro H, Lee T, et al: Evaluation of the clinical utility of the ICG fluorescence method compared with the radioisotope method for sentinel lymph node biopsy in breast cancer. Ann Surg Oncol. 23:44–50. 2016.PubMed/NCBI View Article : Google Scholar

6 

Nakagawa Y, Kobayashi K, Kuwabara S, Shibuya H and Nishimaki T: Use of indocyanine green fluorescence imaging to determine the area of bowel resection in non-occlusive mesenteric ischemia: A case report. Int J Surg Case Rep. 51:352–357. 2018.PubMed/NCBI View Article : Google Scholar

7 

Irie T, Matsutani T, Hagiwara N, Nomura T, Fujita I, Kanazawa Y, Kakinuma D and Uchida E: Successful treatment of non-occlusive mesenteric ischemia with indocyanine green fluorescence and open-abdomen management. Clin J Gastroenterol. 10:514–518. 2017.PubMed/NCBI View Article : Google Scholar

8 

Nitori N, Deguchi T, Kubota K, Yoshida M, Kato A, Kojima M, Kadomura T, Okada A, Okamura J, Kobayashi M, et al: Successful treatment of non-occlusive mesenteric ischemia (NOMI) using the HyperEye Medical System™ for intraoperative visualization of the mesenteric and bowel circulation: Report of a case. Surg Today. 44:359–362. 2014.PubMed/NCBI View Article : Google Scholar

9 

Arezzo A, Bonino MA, Ris F, Boni L, Cassinotti E, Foo DC, Shum NF, Brolese A, Ciarleglio F, Keller DS, et al: Intraoperative use of fluorescence with indocyanine green reduces anastomotic leak rates in rectal cancer surgery: An individual participant data analysis. Surg Endosc. 34:4281–4290. 2020.PubMed/NCBI View Article : Google Scholar

10 

Mun M, Okumura S, Nakao M, Matsuura Y and Nakagawa K: Indocyanine green fluorescence-navigated thoracoscopic anatomical segmentectomy. J Vis Surg. 3(80)2017.PubMed/NCBI View Article : Google Scholar

11 

Nishino H, Takano S, Yoshitomi H, Furukawa K, Takayashiki T, Kuboki S, Suzuki D, Sakai N, Kagawa S, Nojima H, et al: Ischemic gastropathy after distal pancreatectomy with en bloc celiac axis resection versus distal pancreatectomy for pancreatic body/tail cancer. Surg Open Sci. 1:14–19. 2019.PubMed/NCBI View Article : Google Scholar

12 

Ishizawa T, Fukushima N, Shibahara J, Masuda K, Tamura S, Aoki T, Hasegawa K, Beck Y, Fukayama M and Kokudo N: Real-time identification of liver cancers by using indocyanine green fluorescent imaging. Cancer. 115:2491–2504. 2009.PubMed/NCBI View Article : Google Scholar

13 

Felli E, Ishizawa T, Cherkaoui Z, Diana M, Tripon S, Baumert TF, Schuster C and Pessaux P: Laparoscopic anatomical liver resection for malignancies using positive or negative staining technique with intraoperative indocyanine green-fluorescence imaging. HPB (Oxford): Jun 7, 2021 (Epub ahead of print).

14 

Nanashima A, Tominaga T, Sumida Y, Tobinaga S and Nagayasu T: Indocyanine green identification for tumor infiltration or metastasis originating from hepatocellular carcinoma. Int J Surg Case Rep. 46:56–61. 2018.PubMed/NCBI View Article : Google Scholar

15 

He P, Huang T, Fang C, Su S, Tian J, Xia X and Li B: Identification of extrahepatic metastasis of hepatocellular carcinoma using indocyanine green fluorescence imaging. Photodiagn Photodyn Ther. 25:417–420. 2019.PubMed/NCBI View Article : Google Scholar

16 

Ishizawa T, Masuda K, Urano Y, Kawaguchi Y, Satou S, Kaneko J, Hasegawa K, Shibahara J, Fukayama M, Tsuji S, et al: Mechanistic background and clinical applications of indocyanine green fluorescence imaging of hepatocellular carcinoma. Ann Surg Oncol. 21:440–448. 2014.PubMed/NCBI View Article : Google Scholar

17 

Ishizawa T and Saiura A: Fluorescence imaging for minimally invasive cancer surgery. Surg Oncol Clin N Am. 28:45–60. 2019.PubMed/NCBI View Article : Google Scholar

18 

Yamamura K, Beppu T, Sato N, Kinoshita K, Oda E, Yuki H, Motohara T, Miyamoto H, Komohara Y and Akahoshi S: Complete removal of adrenal metastasis in hepatocellular carcinoma using indocyanine green fluorescent imaging. Anticancer Res. 40:5823–5828. 2020.PubMed/NCBI View Article : Google Scholar

19 

Ishizawa T, Bandai Y and Kokudo N: Fluorescent cholangiography using indocyanine green for laparoscopic cholecystectomy: An initial experience. Arch Surg. 144:381–382. 2009.PubMed/NCBI View Article : Google Scholar

20 

Kim M, Lee S, Park JC, Jang DM, Ha SI, Kim JU, Ahn JS and Park W: Anaphylactic shock after indocyanine green video angiography during cerebrovascular surgery. World Neurosurg. 133:74–79. 2020.PubMed/NCBI View Article : Google Scholar

21 

Chu W, Chennamsetty A, Toroussian R and Lau C: Anaphylactic shock after intravenous administration of indocyanine green during robotic partial nephrectomy. Urol Case Rep. 12:37–38. 2017.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Sasaki S, Takahashi M, Hayashi T, Morita Y, Namiki S and Itagaki S: Utility of X‑ray and indocyanine green fluorescence imaging in detecting hepatocellular carcinoma dissemination on laparoscopic surgery: A case report. Mol Clin Oncol 15: 259, 2021.
APA
Sasaki, S., Takahashi, M., Hayashi, T., Morita, Y., Namiki, S., & Itagaki, S. (2021). Utility of X‑ray and indocyanine green fluorescence imaging in detecting hepatocellular carcinoma dissemination on laparoscopic surgery: A case report. Molecular and Clinical Oncology, 15, 259. https://doi.org/10.3892/mco.2021.2421
MLA
Sasaki, S., Takahashi, M., Hayashi, T., Morita, Y., Namiki, S., Itagaki, S."Utility of X‑ray and indocyanine green fluorescence imaging in detecting hepatocellular carcinoma dissemination on laparoscopic surgery: A case report". Molecular and Clinical Oncology 15.6 (2021): 259.
Chicago
Sasaki, S., Takahashi, M., Hayashi, T., Morita, Y., Namiki, S., Itagaki, S."Utility of X‑ray and indocyanine green fluorescence imaging in detecting hepatocellular carcinoma dissemination on laparoscopic surgery: A case report". Molecular and Clinical Oncology 15, no. 6 (2021): 259. https://doi.org/10.3892/mco.2021.2421
Copy and paste a formatted citation
x
Spandidos Publications style
Sasaki S, Takahashi M, Hayashi T, Morita Y, Namiki S and Itagaki S: Utility of X‑ray and indocyanine green fluorescence imaging in detecting hepatocellular carcinoma dissemination on laparoscopic surgery: A case report. Mol Clin Oncol 15: 259, 2021.
APA
Sasaki, S., Takahashi, M., Hayashi, T., Morita, Y., Namiki, S., & Itagaki, S. (2021). Utility of X‑ray and indocyanine green fluorescence imaging in detecting hepatocellular carcinoma dissemination on laparoscopic surgery: A case report. Molecular and Clinical Oncology, 15, 259. https://doi.org/10.3892/mco.2021.2421
MLA
Sasaki, S., Takahashi, M., Hayashi, T., Morita, Y., Namiki, S., Itagaki, S."Utility of X‑ray and indocyanine green fluorescence imaging in detecting hepatocellular carcinoma dissemination on laparoscopic surgery: A case report". Molecular and Clinical Oncology 15.6 (2021): 259.
Chicago
Sasaki, S., Takahashi, M., Hayashi, T., Morita, Y., Namiki, S., Itagaki, S."Utility of X‑ray and indocyanine green fluorescence imaging in detecting hepatocellular carcinoma dissemination on laparoscopic surgery: A case report". Molecular and Clinical Oncology 15, no. 6 (2021): 259. https://doi.org/10.3892/mco.2021.2421
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