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Molecular and Clinical Oncology
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Case Report Open Access

Leiomyosarcoma of the splenic vein with a history of bilateral retinoblastoma: A case report and review of the literature

  • Authors:
    • Miho Akabane
    • Masaji Hashimoto
    • Yutaka Takazawa
    • Daisuke Hattori
    • Rikako Koyama
    • Tsunao Imamura
  • View Affiliations / Copyright

    Affiliations: Division of Hepatobiliary‑Pancreatic Surgery, Department of Gastroenterological Surgery, Toranomon Hospital, Tokyo 105‑8470, Japan, Department of Pathology, Toranomon Hospital, Tokyo 105‑8470, Japan, Department of Gastroenterology, Toranomon Hospital, Tokyo 105‑8470, Japan
    Copyright: © Akabane et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 35
    |
    Published online on: December 16, 2021
       https://doi.org/10.3892/mco.2021.2468
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Abstract

Diagnosing leiomyosarcomas of the splenic vein is challenging, and a treatment strategy has not yet been established for this condition. We herein report the case of a 45‑year‑old female patient with a history of retinoblastoma who underwent pancreatosplenectomy for a primary leiomyosarcoma originating from the splenic vein and transcatheter arterial chemoembolization for metastatic hepatic lesions observed 5 months postoperatively. An initial medical check‑up using abdominal ultrasound revealed a 40‑mm mass behind the pancreatic tail. Imaging tests revealed a well‑circumscribed mass compressing the pancreas posteriorly, without invasion into the pancreatic duct. The splenic vein was torn, with the epiploic veins developed as collateral blood vessels, which was an atypical finding for carcinoma. The patient was followed up regularly. At 5 years after the first visit, an abdominal ultrasound showed that the mass had increased in size to 50 mm, and had developed into a tumor embolus within the splenic vein, causing an obstruction of the vessel. Pancreatosplenectomy was performed due to suspicion of malignancy. The final diagnosis was leiomyosarcoma arising from the splenic vein. The patient was discharged on postoperative day 15 and was followed up regularly thereafter. Imaging studies performed 5 months postoperatively revealed four hepatic lesions. The hepatic masses were histologically diagnosed as metastatic leiomyosarcomas, and transcatheter arterial chemoembolization was performed using epirubicin. Since then, regular follow‑ups have been conducted without observed recurrence. Leiomyosarcoma of the splenic vein is exceedingly rare, and the number of reported cases is not sufficient to establish clinical guidelines. Therefore, it is crucial to collect more reports on the occurrence and treatment of this disease.
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Copy and paste a formatted citation
Spandidos Publications style
Akabane M, Hashimoto M, Takazawa Y, Hattori D, Koyama R and Imamura T: Leiomyosarcoma of the splenic vein with a history of bilateral retinoblastoma: A case report and review of the literature. Mol Clin Oncol 16: 35, 2022.
APA
Akabane, M., Hashimoto, M., Takazawa, Y., Hattori, D., Koyama, R., & Imamura, T. (2022). Leiomyosarcoma of the splenic vein with a history of bilateral retinoblastoma: A case report and review of the literature. Molecular and Clinical Oncology, 16, 35. https://doi.org/10.3892/mco.2021.2468
MLA
Akabane, M., Hashimoto, M., Takazawa, Y., Hattori, D., Koyama, R., Imamura, T."Leiomyosarcoma of the splenic vein with a history of bilateral retinoblastoma: A case report and review of the literature". Molecular and Clinical Oncology 16.2 (2022): 35.
Chicago
Akabane, M., Hashimoto, M., Takazawa, Y., Hattori, D., Koyama, R., Imamura, T."Leiomyosarcoma of the splenic vein with a history of bilateral retinoblastoma: A case report and review of the literature". Molecular and Clinical Oncology 16, no. 2 (2022): 35. https://doi.org/10.3892/mco.2021.2468
Copy and paste a formatted citation
x
Spandidos Publications style
Akabane M, Hashimoto M, Takazawa Y, Hattori D, Koyama R and Imamura T: Leiomyosarcoma of the splenic vein with a history of bilateral retinoblastoma: A case report and review of the literature. Mol Clin Oncol 16: 35, 2022.
APA
Akabane, M., Hashimoto, M., Takazawa, Y., Hattori, D., Koyama, R., & Imamura, T. (2022). Leiomyosarcoma of the splenic vein with a history of bilateral retinoblastoma: A case report and review of the literature. Molecular and Clinical Oncology, 16, 35. https://doi.org/10.3892/mco.2021.2468
MLA
Akabane, M., Hashimoto, M., Takazawa, Y., Hattori, D., Koyama, R., Imamura, T."Leiomyosarcoma of the splenic vein with a history of bilateral retinoblastoma: A case report and review of the literature". Molecular and Clinical Oncology 16.2 (2022): 35.
Chicago
Akabane, M., Hashimoto, M., Takazawa, Y., Hattori, D., Koyama, R., Imamura, T."Leiomyosarcoma of the splenic vein with a history of bilateral retinoblastoma: A case report and review of the literature". Molecular and Clinical Oncology 16, no. 2 (2022): 35. https://doi.org/10.3892/mco.2021.2468
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