Open Access

Therapeutic efficacy of lenvatinib for hepatocellular carcinoma with iso‑high intensity in the hepatobiliary phase of Gd‑EOB‑DTPA‑MRI

  • Authors:
    • Akifumi Kuwano
    • Kosuke Tanaka
    • Masayoshi Yada
    • Shigehiro Nagasawa
    • Yusuke Morita
    • Akihide Masumoto
    • Kenta Motomura
  • View Affiliations

  • Published online on: December 24, 2021     https://doi.org/10.3892/mco.2021.2486
  • Article Number: 53
  • Copyright: © Kuwano et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Previous studies have reported that hepatocellular carcinoma (HCC) harboring WNT/β‑catenin mutations exhibits iso‑high intensity by gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid‑enhanced magnetic resonance imaging (Gd‑EOB‑DTPA‑MRI, i.e. EOB‑MRI) during the hepatobiliary phase (HBP), thus indicating that EOB‑MRI may help clinicians identify an immune exclusion class, which might not respond to treatment with immune checkpoint inhibitors. The present study analyzed the efficacy of lenvatinib for HCC with iso‑high intensity during the HBP of EOB‑MRI. Overall, 52 patients who underwent EOB‑MRI for 140 HCC nodules were classified into iso‑high‑intensity and low‑intensity groups during the HBP of EOB‑MRI. The clinical and histological characteristics, and different responses to treatment of both groups were analyzed. The expression levels of β‑catenin and glutamine synthetase, indicative of WNT/β‑catenin mutations, were enhanced in the HCC with iso‑high‑intensity group. Nine patients had iso‑high intensity, whereas 43 patients had low intensity. Tumor size was larger, and the levels of antagonist‑II or vitamin K absence were higher in the iso‑high‑intensity group. Furthermore, 3/9 patients in the iso‑high‑intensity group had objective responses compared with 13/43 patients in the low‑intensity group. Disease control was observed in 5/9 patients in the iso‑high‑intensity group and 26/43 patients in the low‑intensity group. Median overall survival was 29.8 months for the iso‑high‑intensity group compared with 20.8 months for the low‑intensity group. In the iso‑high‑intensity group, the median progression‑free survival rate was 6.7 months compared with 5.6 months in the low‑intensity group. No differences in best percentage change from baseline tumor size were observed in either group. Although few patients were included in this study, the present findings suggested that the efficacy of lenvatinib was unaffected by signal intensity during the HBP of EOB‑MRI.
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Spandidos Publications style
Kuwano A, Tanaka K, Yada M, Nagasawa S, Morita Y, Masumoto A and Motomura K: Therapeutic efficacy of lenvatinib for hepatocellular carcinoma with iso‑high intensity in the hepatobiliary phase of Gd‑EOB‑DTPA‑MRI. Mol Clin Oncol 16: 53, 2022
APA
Kuwano, A., Tanaka, K., Yada, M., Nagasawa, S., Morita, Y., Masumoto, A., & Motomura, K. (2022). Therapeutic efficacy of lenvatinib for hepatocellular carcinoma with iso‑high intensity in the hepatobiliary phase of Gd‑EOB‑DTPA‑MRI. Molecular and Clinical Oncology, 16, 53. https://doi.org/10.3892/mco.2021.2486
MLA
Kuwano, A., Tanaka, K., Yada, M., Nagasawa, S., Morita, Y., Masumoto, A., Motomura, K."Therapeutic efficacy of lenvatinib for hepatocellular carcinoma with iso‑high intensity in the hepatobiliary phase of Gd‑EOB‑DTPA‑MRI". Molecular and Clinical Oncology 16.2 (2022): 53.
Chicago
Kuwano, A., Tanaka, K., Yada, M., Nagasawa, S., Morita, Y., Masumoto, A., Motomura, K."Therapeutic efficacy of lenvatinib for hepatocellular carcinoma with iso‑high intensity in the hepatobiliary phase of Gd‑EOB‑DTPA‑MRI". Molecular and Clinical Oncology 16, no. 2 (2022): 53. https://doi.org/10.3892/mco.2021.2486