Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
March-2022 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2022 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Actual practice of Kochi oxydol radiation therapy for unresectable carcinomas by intra‑tumoral administration of hydrogen peroxide as a radiosensitizer

  • Authors:
    • Shiro Obata
    • Yutaka Ishimaru
    • Shigenori Miyagi
    • Mika Nakatake
    • Akira Kuroiwa
    • Yoshiaki Ohta
    • Tsunehiko Kan
    • Shinya Kanegae
    • Yohta Inoue
    • Rhoichi Nishizato
    • Kohki Miyazaki
  • View Affiliations / Copyright

    Affiliations: Department of Radiology and Radiotherapy, Nagasaki Prefecture Shimabara Hospital, Shimabara, Nagasaki 855‑0861, Japan
    Copyright: © Obata et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 68
    |
    Published online on: January 21, 2022
       https://doi.org/10.3892/mco.2022.2501
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Kochi oxydol radiation therapy for unresectable carcinomas (KORTUC) is a novel cancer treatment method developed in Japan. KORTUC targets resistance factors in cancer therapy, such as low‑oxygen environments and excessive antioxidant enzymes. This may enhance the effects of conventional treatments. The present study reports the experience of the Nagasaki Prefecture Shimabara Hospital in using KORTUC treatment for a series of 210 patients between January 2010 and June 2019. When this radiosensitizer, a mixture of a dilute hydrogen peroxide solution (0.5 ml, 3%/unit) and sodium hyaluronate (2.5 ml, 0.83%/unit), is administered and applied directly to the cancer lesion, antioxidant enzymes are neutralized and degraded causing reoxygenation as a secondary by‑product, thereby enhancing the cytotoxic effect of radiation. The radiosensitizer was administered twice per week before irradiation. Up to June 2019, KORTUC was administered to 210 patients. The most common disease stage was stage IV in 137 patients (65%), followed by stage III in 25 patients, stage I in 17 patients and stage II in 7 patients (unknown disease stage in 24 patients). Of the 186 patients who could be followed up after the treatment, 28 (15%) patients had a complete response (Response Evaluation Criteria in Solid Tumors version 1.1), 59 (32%) had a partial response, 73 (39%) had stable disease and 26 (14%) had progressive disease. No significant treatment‑related adverse events were observed. The present study highlights the reports of 4 cases (3 cases from among the 28 patients with complete responses): i) A case of advanced, inoperable breast cancer; ii) a refractory patient with recurrence a decade after postoperative irradiation; iii) a patient with advanced, inoperable rectal cancer; and iv) a patient with lymph node metastases. Overall, KORTUC showed good efficacy and tolerable safety for various types of radioresistant tumors, and it has the potential for immediate worldwide use.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Ogawa Y, Yamashita T, Masunaga S, Kariya S, Tokuhiro S, Aoyama N, Tsuzuki A, Yaogawa S, Kubota K, Nishioka A, et al: A new enzyme-targeting and radio-sensitization treatment; basics and clinical practice of KORTUC Shinoharashinsha Pub. Inc., Tokyo, 2015 (In Japanese).

2 

Ogawa Y, Takahashi T, Kobayashi T, Kariya S, Nishioka A, Hamasato S, Moriki T, Seguchi H, Yoshida S and Sonobe H: Immunocytochemical characteristics of human osteosarcoma cell line HS-Os-1: Possible implication in apoptotic resistance against irradiation. Int J Mol Med. 14:397–403. 2004.PubMed/NCBI

3 

Kariya S, Sawada K, Kobayashi T, Karashima T, Shuin T, Nishioka A and Ogawa Y: Combination treatment of hydrogen peroxide and X-rays induces apoptosis in human prostate cancer PC-3 cells. Int J Radiat Oncol Biol Phys. 75:449–454. 2009.PubMed/NCBI View Article : Google Scholar

4 

Ogawa Y, Takahashi T, Kobayashi T, Toda M, Nishioka A, Kariya S, Seguchi H, Yamamoto H and Yoshida S: Comparison of radiation-induced reactive oxygen species formation in adult articular chondrocytes and that in human peripheral T cells: Possible implication in radiosensitivity. Int J Mol Med. 11:455–459. 2003.PubMed/NCBI

5 

Ogawa Y: Paradigm shift in radiation biology/radiation oncology-exploitation of the ‘H2O2 Effect’ for radiotherapy using low-LET (Linear Energy Transfer) Radiation such as X-rays and high-energy electrons. Cancers (Basel). 8(28)2016.PubMed/NCBI View Article : Google Scholar

6 

Ogawa Y, Kubota K, Aoyama N, Yamanishi T, Kariya S, Hamada N, Nogami M, Nishioka A, Onogawa M and Miyamura M: Non-surgical breast-conserving treatment (KORTUC-BCT) using a new radio-sensitization method (KORTUC II) for patients with stage I or II breast cancer. Cancers (Basel). 7:2277–2289. 2015.PubMed/NCBI View Article : Google Scholar

7 

Nimalasena S, Gothard L, Anbalagan S, Allen S, Sinnett V, Mohammed K, Kothari G, Musallam A, Lucy C, Yu S, et al: Intratumoral hydrogen peroxide with radiation therapy in locally advanced breast cancer: Results from a phase 1 clinical trial. Int J Radiat Oncol Biol Phys. 108:1019–1029. 2020.PubMed/NCBI View Article : Google Scholar

8 

Tokuhiro S, Ogawa Y, Tsuzuki K, Akima R, Ue H, Kariya S and Nishioka A: Development of a new enzyme-targeting radiosensitizer (KORTUC) containing hydrogen peroxide for intratumoral injection for patients with low linear energy transfer (LET) radioresistant neoplasms. Oncol Lett. 1:1025–1028. 2010.PubMed/NCBI View Article : Google Scholar

9 

Christensen ES: Iatrogenic dissemination of tumor cells-dissemination of tumor cells along the needle track after percutaneous, transthoracic lung biopsy. Dan Med Bull. 25:82–87. 1978.PubMed/NCBI

10 

Sinner WN and Zajicek J: Implantation metastasis after percutaneous transthoracic needle aspiration biopsy. Acta Radiol Diagn (Stockh). 17:473–480. 1976.PubMed/NCBI View Article : Google Scholar

11 

Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, et al: New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–247. 2009.PubMed/NCBI View Article : Google Scholar

12 

National Cancer Institute (NCI): Common Terminology Criteria for Adverse Events (CTCAE) v4.0. https://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03/. Accessed November 25, 2021.

13 

Gebski V, Lagleva M, Keech A, Simes J and Langlands AO: Survival effects of postmastectomy adjuvant radiation therapy using biologically equivalent doses: A clinical perspective. J Natl Cancer Inst. 98:26–38. 2006.PubMed/NCBI View Article : Google Scholar

14 

ECOG-ACRIN cancer Research Group: ECOG Performance Status. https://ecog-acrin.org/resources/ecog-performance-status. Accessed November 25, 2021.

15 

Obata S, Ogihara Y, Ohta Y, Kan T, Kanegae S, Inoue Y, Kuroiwa A, Inoue K, Yamanishi M, Hayashi T, et al: Possibility of a ‘sentinel effect’ in chemoradiotherapy and a new radiosensitizer injection (KORTUC). Jpn J Clin Radiol. 63:317–327. 2018.(In Japanese).

16 

U.S. Food and Drug Administration: KYMRIAH (tisagenlecleucel) https://www.fda.gov/vaccines-blood-biologics/cellular-gene-therapy-products/kymriah-tisagenlecleucel. Accessed November 25, 2021.

17 

Vaupel P: The role of hypoxia-induced factors in tumor progression. Oncologist. 9 (Suppl 5):S10–S17. 2004.PubMed/NCBI View Article : Google Scholar

18 

Clevers H: The cancer stem cell: Premises, promises and challenges. Nat Med. 17:313–319. 2011.PubMed/NCBI View Article : Google Scholar

19 

Li L and Bhatia R: Stem cell quiescence. Clin Cancer Res. 17:4936–4941. 2011.PubMed/NCBI View Article : Google Scholar

20 

Takeishi S, Matsumoto A, Onoyama I, Naka K, Hirao A and Nakayama KI: Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence. Cancer Cell. 23:347–361. 2013.PubMed/NCBI View Article : Google Scholar

21 

Iriuchishima H, Takubo K, Matsuoka S, Onoyama I, Nakayama KI, Nojima Y and Suda T: Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7 and alpha; overexpression. Blood. 117:2373–2377. 2011.PubMed/NCBI View Article : Google Scholar

22 

Taniyama Y and Griendling KK: Reactive oxygen species in the vasculature: Molecular and cellular mechanisms. Hypertension. 42:1075–1081. 2003.PubMed/NCBI View Article : Google Scholar

23 

Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, Squadrito F, Altavilla D and Bitto A: Oxidative stress: Harms and benefits for human health. Oxid Med Cell Longev. 2017(8416763)2017.PubMed/NCBI View Article : Google Scholar

24 

Kobayashi M and Harada H: Hypoxic stress and HIF. Seikagaku. 85:187–195. 2013.PubMed/NCBI(In Japanese).

25 

Ogawa Y, Ue H, Tsuzuki K, Tadokoro M, Miyatake K, Sasaki T, Yokota N, Hamada N, Kariya S, Hitomi J, et al: New radio-sensitization treatment (KORTUC I) using hydrogen peroxide solution-soaked gauze bolus for unresectable and superficially exposed neoplasms. Oncol Rep. 19:1389–1394. 2008.PubMed/NCBI

26 

Miyatake K, Kubota K, Ogawa Y, Hamada N, Murata Y and Nishioka A: Non-surgical care for locally advanced breast cancer: Radiologically assessed therapeutic outcome of a new enzyme-targeting radio-sensitization treatment, Kochi Oxydol-radiation therapy for unresectable Carcinomas, Type II (KORTUC II) with systemic chemotherapy. Oncol Rep. 24:1161–1168. 2010.PubMed/NCBI View Article : Google Scholar

27 

Ogawa Y, Kubota K, Ue H, Tadokoro M, Matsui R, Yamanishi T, Hamada N, Kariya S, Nishioka A, Nakajima H, et al: Safety and effectiveness of a new enzyme-targeting radio-sensitization treatment (KORTUC II) for intratumoral injection for low-LET radio-resistant tumors. Int J Oncol. 39:553–560. 2011.PubMed/NCBI View Article : Google Scholar

28 

Chapman JD, Dugle DL, Reuvers AP, Meeker BE and Borsa J: Studies on the radio-sensitizing effect of oxygen in Chinese hamster cells. Int J Radiat Biol Relat Stud Phys Chem Med. 26:383–389. 1974.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Obata S, Ishimaru Y, Miyagi S, Nakatake M, Kuroiwa A, Ohta Y, Kan T, Kanegae S, Inoue Y, Nishizato R, Nishizato R, et al: Actual practice of Kochi oxydol radiation therapy for unresectable carcinomas by intra‑tumoral administration of hydrogen peroxide as a radiosensitizer. Mol Clin Oncol 16: 68, 2022.
APA
Obata, S., Ishimaru, Y., Miyagi, S., Nakatake, M., Kuroiwa, A., Ohta, Y. ... Miyazaki, K. (2022). Actual practice of Kochi oxydol radiation therapy for unresectable carcinomas by intra‑tumoral administration of hydrogen peroxide as a radiosensitizer. Molecular and Clinical Oncology, 16, 68. https://doi.org/10.3892/mco.2022.2501
MLA
Obata, S., Ishimaru, Y., Miyagi, S., Nakatake, M., Kuroiwa, A., Ohta, Y., Kan, T., Kanegae, S., Inoue, Y., Nishizato, R., Miyazaki, K."Actual practice of Kochi oxydol radiation therapy for unresectable carcinomas by intra‑tumoral administration of hydrogen peroxide as a radiosensitizer". Molecular and Clinical Oncology 16.3 (2022): 68.
Chicago
Obata, S., Ishimaru, Y., Miyagi, S., Nakatake, M., Kuroiwa, A., Ohta, Y., Kan, T., Kanegae, S., Inoue, Y., Nishizato, R., Miyazaki, K."Actual practice of Kochi oxydol radiation therapy for unresectable carcinomas by intra‑tumoral administration of hydrogen peroxide as a radiosensitizer". Molecular and Clinical Oncology 16, no. 3 (2022): 68. https://doi.org/10.3892/mco.2022.2501
Copy and paste a formatted citation
x
Spandidos Publications style
Obata S, Ishimaru Y, Miyagi S, Nakatake M, Kuroiwa A, Ohta Y, Kan T, Kanegae S, Inoue Y, Nishizato R, Nishizato R, et al: Actual practice of Kochi oxydol radiation therapy for unresectable carcinomas by intra‑tumoral administration of hydrogen peroxide as a radiosensitizer. Mol Clin Oncol 16: 68, 2022.
APA
Obata, S., Ishimaru, Y., Miyagi, S., Nakatake, M., Kuroiwa, A., Ohta, Y. ... Miyazaki, K. (2022). Actual practice of Kochi oxydol radiation therapy for unresectable carcinomas by intra‑tumoral administration of hydrogen peroxide as a radiosensitizer. Molecular and Clinical Oncology, 16, 68. https://doi.org/10.3892/mco.2022.2501
MLA
Obata, S., Ishimaru, Y., Miyagi, S., Nakatake, M., Kuroiwa, A., Ohta, Y., Kan, T., Kanegae, S., Inoue, Y., Nishizato, R., Miyazaki, K."Actual practice of Kochi oxydol radiation therapy for unresectable carcinomas by intra‑tumoral administration of hydrogen peroxide as a radiosensitizer". Molecular and Clinical Oncology 16.3 (2022): 68.
Chicago
Obata, S., Ishimaru, Y., Miyagi, S., Nakatake, M., Kuroiwa, A., Ohta, Y., Kan, T., Kanegae, S., Inoue, Y., Nishizato, R., Miyazaki, K."Actual practice of Kochi oxydol radiation therapy for unresectable carcinomas by intra‑tumoral administration of hydrogen peroxide as a radiosensitizer". Molecular and Clinical Oncology 16, no. 3 (2022): 68. https://doi.org/10.3892/mco.2022.2501
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team