Open Access

Carboplatin plus nanoparticle albumin‑bound paclitaxel for the treatment of thymic carcinoma

  • Authors:
    • Akiko Takahashi
    • Rintaro Noro
    • Natsuki Takano
    • Kakeru Hisakane
    • Satoshi Takahashi
    • Aya Fukuizumi
    • Miwako Omori
    • Teppei Sugano
    • Susumu Takeuchi
    • Shinji Nakamichi
    • Akihiko Miyanaga
    • Yuji Minegishi
    • Kaoru Kubota
    • Masahiro Seike
    • Akihiko Gemma
  • View Affiliations

  • Published online on: February 21, 2022     https://doi.org/10.3892/mco.2022.2520
  • Article Number: 87
  • Copyright: © Takahashi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Thymic carcinoma is a relatively rare type of malignant tumor. The present retrospective study evaluated the efficacy and safety of carboplatin plus nanoparticle albumin‑bound paclitaxel for the treatment of advanced thymic carcinoma. The study included data from 12 patients with advanced thymic carcinoma treated in the Nippon Medical School Hospital (Tokyo, Japan). Response to treatment, patient survival and treatment safety were assessed. The objective response rate was 66.7% (8/12 patients). Disease control was achieved in 11 patients (91.7%). At the median follow‑up time of 27.6 months (range, 6.2‑75.1 months), the median progression‑free survival and median first‑line overall survival times were 16.7 months [95% confidence interval (CI), 13.2‑37.7] and 14.3 months (95% CI, 4.7‑54.6), respectively. There was no occurrence of febrile neutropenia or treatment‑related death. The results of the present study showed that carboplatin plus nanoparticle albumin‑bound paclitaxel was effective and safe. Therefore, it is a promising chemotherapy regimen for the treatment of advanced thymic carcinoma.
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April-2022
Volume 16 Issue 4

Print ISSN: 2049-9450
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Spandidos Publications style
Takahashi A, Noro R, Takano N, Hisakane K, Takahashi S, Fukuizumi A, Omori M, Sugano T, Takeuchi S, Nakamichi S, Nakamichi S, et al: Carboplatin plus nanoparticle albumin‑bound paclitaxel for the treatment of thymic carcinoma. Mol Clin Oncol 16: 87, 2022
APA
Takahashi, A., Noro, R., Takano, N., Hisakane, K., Takahashi, S., Fukuizumi, A. ... Gemma, A. (2022). Carboplatin plus nanoparticle albumin‑bound paclitaxel for the treatment of thymic carcinoma. Molecular and Clinical Oncology, 16, 87. https://doi.org/10.3892/mco.2022.2520
MLA
Takahashi, A., Noro, R., Takano, N., Hisakane, K., Takahashi, S., Fukuizumi, A., Omori, M., Sugano, T., Takeuchi, S., Nakamichi, S., Miyanaga, A., Minegishi, Y., Kubota, K., Seike, M., Gemma, A."Carboplatin plus nanoparticle albumin‑bound paclitaxel for the treatment of thymic carcinoma". Molecular and Clinical Oncology 16.4 (2022): 87.
Chicago
Takahashi, A., Noro, R., Takano, N., Hisakane, K., Takahashi, S., Fukuizumi, A., Omori, M., Sugano, T., Takeuchi, S., Nakamichi, S., Miyanaga, A., Minegishi, Y., Kubota, K., Seike, M., Gemma, A."Carboplatin plus nanoparticle albumin‑bound paclitaxel for the treatment of thymic carcinoma". Molecular and Clinical Oncology 16, no. 4 (2022): 87. https://doi.org/10.3892/mco.2022.2520