Collision tumor of small cell carcinoma and squamous cell carcinoma of the maxillary sinus: Case report

Sugianto,Irfan; Yanagi,Yoshinobu; Hisatomi,Miki; Okada,Shunsuke; Takeshita,Yohei; Bamgbose,Babatunde Olamide; Asaumi,Junichi

doi:10.3892/mco.2022.2529

Collision tumor of small cell carcinoma and squamous cell carcinoma of the maxillary sinus: Case report

Authors:
- Irfan Sugianto
- Yoshinobu Yanagi
- Miki Hisatomi
- Shunsuke Okada
- Yohei Takeshita
- Babatunde Olamide Bamgbose
- Junichi Asaumi
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Affiliations: Department of Oral Radiology Faculty of Dentistry Hasanuddin University, Makassar, Sulawesi 90245, Indonesia, Department of Dental Informatics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama 700‑8558, Japan, Department of Oral Diagnosis and Dentomaxillofacial Radiology, Okayama University Hospital, Okayama 700‑8558, Japan, Department of Oral and Maxillofacial Radiology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama 700‑8558, Japan
Published online on: March 4, 2022 https://doi.org/10.3892/mco.2022.2529
Article Number: 96
Copyright: © Sugianto et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

A collision tumor refers to the coexistence of two diagnostically distinct tumors in a common anatomic space. Collision tumors are rare in the oral and maxillofacial region. The present study reported on the case of an 82‑year‑old female with a collision tumor in the maxillary sinus consisting of small cell carcinoma (SmCC) and squamous cell carcinoma (SCC). Computed tomography (CT) imaging revealed a mass in the right maxillary sinus. The lesion exhibited heterogeneous low signal intensity (SI) on T1‑weighted imaging (T1WI), high SI on short T1 inversion recovery and heterogeneous solid enhancement on contrast‑enhanced T1WI. The histopathology result of a biopsy specimen confirmed SmCC. After the patient received a course of chemoradiotherapy, follow‑up CT revealed a residual tumor. In a second surgery, a remaining tumor and histopathology revealed SCC with no evidence of SmCC. The final diagnosis was a collision tumor made up of SCC and SmCC.

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