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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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May-2022 Volume 16 Issue 5

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Case Report

Mediastinal and hilar sarcoid‑like reaction in a patient treated with dabrafenib and trametinib for metastatic melanoma: A case report and review of the literature

  • Authors:
    • Vanessa-Meletia Bala
    • Maria Mitsogianni
    • Konstantinos Laschos
    • Evangelia Pliakou
    • Eirini Lazaridi
    • Dimitra-Ioanna Lampropoulou
    • Gerasimos Aravantinos
  • View Affiliations / Copyright

    Affiliations: 2nd Department of Medical Oncology, General Oncology Hospital of Kifissia ‘Agioi Anargyroi’, Athens 145 64, Greece
  • Article Number: 99
    |
    Published online on: March 18, 2022
       https://doi.org/10.3892/mco.2022.2532
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Abstract

BRAF/MEK inhibitors are considered standard of care in the treatment of advanced BRAF‑mutated malignant melanoma, and have been, in rare cases, associated with granulomatous reactions, mostly limited to skin lesions. The present study reported the case of a patient with metastatic melanoma developing a sarcoid‑like reaction manifesting as asymptomatic mediastinal and right hilar lymphadenopathy while on antineoplastic therapy with dabrafenib and trametinib. To the best of our knowledge, this is the first reported case of isolated lymphadenopathy as a manifestation of drug‑induced sarcoid‑like reaction under dabrafenib and trametinib. Overall, only 17 other cases of granulomatosis have been reported in the literature. Although uncommon, such reactions should be considered in the differential diagnosis of lymph node enlargement, and distinguishing them from tumor progress is important and can be challenging in clinical practice.
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Copy and paste a formatted citation
Spandidos Publications style
Bala V, Mitsogianni M, Laschos K, Pliakou E, Lazaridi E, Lampropoulou D and Aravantinos G: Mediastinal and hilar sarcoid‑like reaction in a patient treated with dabrafenib and trametinib for metastatic melanoma: A case report and review of the literature. Mol Clin Oncol 16: 99, 2022.
APA
Bala, V., Mitsogianni, M., Laschos, K., Pliakou, E., Lazaridi, E., Lampropoulou, D., & Aravantinos, G. (2022). Mediastinal and hilar sarcoid‑like reaction in a patient treated with dabrafenib and trametinib for metastatic melanoma: A case report and review of the literature. Molecular and Clinical Oncology, 16, 99. https://doi.org/10.3892/mco.2022.2532
MLA
Bala, V., Mitsogianni, M., Laschos, K., Pliakou, E., Lazaridi, E., Lampropoulou, D., Aravantinos, G."Mediastinal and hilar sarcoid‑like reaction in a patient treated with dabrafenib and trametinib for metastatic melanoma: A case report and review of the literature". Molecular and Clinical Oncology 16.5 (2022): 99.
Chicago
Bala, V., Mitsogianni, M., Laschos, K., Pliakou, E., Lazaridi, E., Lampropoulou, D., Aravantinos, G."Mediastinal and hilar sarcoid‑like reaction in a patient treated with dabrafenib and trametinib for metastatic melanoma: A case report and review of the literature". Molecular and Clinical Oncology 16, no. 5 (2022): 99. https://doi.org/10.3892/mco.2022.2532
Copy and paste a formatted citation
x
Spandidos Publications style
Bala V, Mitsogianni M, Laschos K, Pliakou E, Lazaridi E, Lampropoulou D and Aravantinos G: Mediastinal and hilar sarcoid‑like reaction in a patient treated with dabrafenib and trametinib for metastatic melanoma: A case report and review of the literature. Mol Clin Oncol 16: 99, 2022.
APA
Bala, V., Mitsogianni, M., Laschos, K., Pliakou, E., Lazaridi, E., Lampropoulou, D., & Aravantinos, G. (2022). Mediastinal and hilar sarcoid‑like reaction in a patient treated with dabrafenib and trametinib for metastatic melanoma: A case report and review of the literature. Molecular and Clinical Oncology, 16, 99. https://doi.org/10.3892/mco.2022.2532
MLA
Bala, V., Mitsogianni, M., Laschos, K., Pliakou, E., Lazaridi, E., Lampropoulou, D., Aravantinos, G."Mediastinal and hilar sarcoid‑like reaction in a patient treated with dabrafenib and trametinib for metastatic melanoma: A case report and review of the literature". Molecular and Clinical Oncology 16.5 (2022): 99.
Chicago
Bala, V., Mitsogianni, M., Laschos, K., Pliakou, E., Lazaridi, E., Lampropoulou, D., Aravantinos, G."Mediastinal and hilar sarcoid‑like reaction in a patient treated with dabrafenib and trametinib for metastatic melanoma: A case report and review of the literature". Molecular and Clinical Oncology 16, no. 5 (2022): 99. https://doi.org/10.3892/mco.2022.2532
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