Predictive features of borderline ovarian tumor recurrence in patients with childbearing potential undergoing conservative treatment

  • Authors:
    • Vito Andrea Capozzi
    • Stefano Cianci
    • Elisa Scarpelli
    • Luciano Monfardini
    • Alessadra Cianciolo
    • Giuseppe Barresi
    • Marcello Ceccaroni
    • Giulio Sozzi
    • Vincenzo Dario Mandato
    • Stefano Uccella
    • Massimo Franchi
    • Vito Chinatera
    • Roberto Berretta
  • View Affiliations

  • Published online on: June 7, 2022     https://doi.org/10.3892/mco.2022.2554
  • Article Number: 121
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Abstract

Abstract. Borderline ovarian tumors (BOT) represent 10‑12% of ovarian cancer cases with a higher prevalence in young patients. Although reproductive outcomes are satisfactory after conservative treatment, several authors reported a higher relapse rate in patients undergoing fertility‑sparing surgery compared with radical treatment. The aim of the present study was to identify predictive factors of BOT recurrence in patients with childbearing potential undergoing conservative treatment with unilateral salpingo‑oophorectomy. From January 2010 to December 2020 all patients with childbearing potential undergoing conservative treatment for early‑stage BOT were included in the analysis. Expert sonographers performed the ultrasounds and classified the ovarian lesion according to International Ovarian Tumor Analysis criteria. A total of 230 patients with BOT that underwent surgical treatment during the study period were analyzed. Of these, 82 patients met the inclusion criteria. Relapse was experienced in 11 cases (13.4%), one (1.2%) peritoneal surface and 10 (12.2%) recurrences on the contralateral ovary. Ovarian tumor size >50 mm (P=0.032; OR 7.317; 95% CI 0.89‑60.29), multilocular cysts >10 loculi (P=0.016; OR 7.543; 95% CI 1.64‑34.78), cysts with >4 papillae (P=0.025; OR 6.190; 95% CI 1.40‑27.36) were statistically correlated with recurrent BOT. Overall, the present study showed that lesions with maximum diameter >50 mm (P=0.014), multilocular cysts >10 loculi (P=0.012) and cysts with >4 papillae (P=0.003) were independent predictive factors of BOT recurrence (P<0.001; correlation coefficient R=0.481) in patients with the potential to bear children undergoing conservative treatment.
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July-2022
Volume 17 Issue 1

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Spandidos Publications style
Capozzi VA, Cianci S, Scarpelli E, Monfardini L, Cianciolo A, Barresi G, Ceccaroni M, Sozzi G, Mandato VD, Uccella S, Uccella S, et al: Predictive features of borderline ovarian tumor recurrence in patients with childbearing potential undergoing conservative treatment. Mol Clin Oncol 17: 121, 2022
APA
Capozzi, V.A., Cianci, S., Scarpelli, E., Monfardini, L., Cianciolo, A., Barresi, G. ... Berretta, R. (2022). Predictive features of borderline ovarian tumor recurrence in patients with childbearing potential undergoing conservative treatment. Molecular and Clinical Oncology, 17, 121. https://doi.org/10.3892/mco.2022.2554
MLA
Capozzi, V. A., Cianci, S., Scarpelli, E., Monfardini, L., Cianciolo, A., Barresi, G., Ceccaroni, M., Sozzi, G., Mandato, V. D., Uccella, S., Franchi, M., Chinatera, V., Berretta, R."Predictive features of borderline ovarian tumor recurrence in patients with childbearing potential undergoing conservative treatment". Molecular and Clinical Oncology 17.1 (2022): 121.
Chicago
Capozzi, V. A., Cianci, S., Scarpelli, E., Monfardini, L., Cianciolo, A., Barresi, G., Ceccaroni, M., Sozzi, G., Mandato, V. D., Uccella, S., Franchi, M., Chinatera, V., Berretta, R."Predictive features of borderline ovarian tumor recurrence in patients with childbearing potential undergoing conservative treatment". Molecular and Clinical Oncology 17, no. 1 (2022): 121. https://doi.org/10.3892/mco.2022.2554