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Overexpression of Annexin A1 is associated with the formation of capillaries in infantile hemangioma

  • Authors:
    • Xinyuan Pan
    • Huang Hui
    • Xiaopin Teng
    • Kuicheng Wei
  • View Affiliations / Copyright

    Affiliations: Department of Plastic Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China, Department of Orthopedics, Minzu Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi Zhuang Autonomous Region 530001, P.R. China
    Copyright: © Pan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 133
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    Published online on: July 12, 2022
       https://doi.org/10.3892/mco.2022.2566
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Abstract

Infantile hemangioma is a common benign tumor in infants. However, the molecular mechanism that controls the proliferation and differentiation of hemangioma is not well understood. Annexin A1 (ANX A1) is a phospholipid‑binding protein involved in a variety of biological processes, including inflammation, cell proliferation and apoptosis. To explore the significance of ANX A1 in the process of proliferation or differentiation of hemangioma, proliferating and involuting hemangioma tissues were collected to detect the expression of ANX A1 using immunohistochemistry and western blotting. Normal skin tissues were used as the negative control. The results revealed that ANX A1 was upregulated in the proliferative phase of hemangioma, and its expression was decreased when the hemangioma entered the involuting phase. Additionally, in the proliferative phase, the strongest staining of ANX A1 was observed in newly born capillaries, and the staining of ANX A1 became weaker in enlarged vessels, indicating that ANX A1 plays an important role in promoting the formation of capillaries. The expression of hypoxia‑inducible factor (HIF)‑1α was positively associated with the expression trend of ANX A1, suggesting that the overexpression of ANX A1 may be associated with the increase of HIF‑1α. In summary, the results of the present study revealed that the expression of ANX A1 was increased in proliferating hemangioma tissue, and that high expression of ANX A1 may be closely associated with the formation of capillaries in infantile hemangioma.
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Copy and paste a formatted citation
Spandidos Publications style
Pan X, Hui H, Teng X and Wei K: Overexpression of Annexin A1 is associated with the formation of capillaries in infantile hemangioma. Mol Clin Oncol 17: 133, 2022.
APA
Pan, X., Hui, H., Teng, X., & Wei, K. (2022). Overexpression of Annexin A1 is associated with the formation of capillaries in infantile hemangioma. Molecular and Clinical Oncology, 17, 133. https://doi.org/10.3892/mco.2022.2566
MLA
Pan, X., Hui, H., Teng, X., Wei, K."Overexpression of Annexin A1 is associated with the formation of capillaries in infantile hemangioma". Molecular and Clinical Oncology 17.3 (2022): 133.
Chicago
Pan, X., Hui, H., Teng, X., Wei, K."Overexpression of Annexin A1 is associated with the formation of capillaries in infantile hemangioma". Molecular and Clinical Oncology 17, no. 3 (2022): 133. https://doi.org/10.3892/mco.2022.2566
Copy and paste a formatted citation
x
Spandidos Publications style
Pan X, Hui H, Teng X and Wei K: Overexpression of Annexin A1 is associated with the formation of capillaries in infantile hemangioma. Mol Clin Oncol 17: 133, 2022.
APA
Pan, X., Hui, H., Teng, X., & Wei, K. (2022). Overexpression of Annexin A1 is associated with the formation of capillaries in infantile hemangioma. Molecular and Clinical Oncology, 17, 133. https://doi.org/10.3892/mco.2022.2566
MLA
Pan, X., Hui, H., Teng, X., Wei, K."Overexpression of Annexin A1 is associated with the formation of capillaries in infantile hemangioma". Molecular and Clinical Oncology 17.3 (2022): 133.
Chicago
Pan, X., Hui, H., Teng, X., Wei, K."Overexpression of Annexin A1 is associated with the formation of capillaries in infantile hemangioma". Molecular and Clinical Oncology 17, no. 3 (2022): 133. https://doi.org/10.3892/mco.2022.2566
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