Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
October-2022 Volume 17 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2022 Volume 17 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Pancreaticoduodenectomy as a feasible choice for periampullary malignancy in octogenarians

  • Authors:
    • Stavros Parasyris
    • Ioannis Hatzaras
    • Vasiliki Ntella
    • Theodoros Sidiropoulos
    • Ioannis Margaris
    • Nikos Pantazis
    • Panagiotis Kokoropoulos
    • Panteleimon Vassiliu
    • Paraskevi Matsota
    • Vasileios Smyrniotis
    • Nikolaos Arkadopoulos
  • View Affiliations / Copyright

    Affiliations: 4th Department of Surgery, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece, Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece, 2nd Department of Anesthesiology, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece
    Copyright: © Parasyris et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 148
    |
    Published online on: August 17, 2022
       https://doi.org/10.3892/mco.2022.2581
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The efficacy and safety of pancreaticoduodenectomy (PD) has not been yet studied in octogenarians in Greece. The present study reviewed records of all consecutive patients that underwent PD at the 4th Surgical Department of Attikon University Hospital (Athens, Greece) between January 1st, 2010 and December 31st, 2019. Differences between two age groups (group Y <80 years; group O >80 years) were analyzed. Study endpoints were length of stay, overall morbidity, 30‑day mortality and overall survival (OS). There were 198 patients in Group Y (mean age, 65 years) and 20 patients in Group O (mean age, 82 years). Octogenarians had worse American Society of Anesthesiology score (>2; 31.3 vs. 65%; P=0.018). Median stay was not significantly different between the two groups (14 days vs. 16 days; P=0.307), neither was the 30‑day mortality (6.1 vs. 5.0%; P>0.99). Median OS was similar between the two groups (35 months vs. 28 months; P=0.577). In a tertiary center in Greece, morbidity and mortality rates after PD were similar between the two groups. Patients should not be denied a PD, solely based on advanced age.
View Figures

Figure 1

Figure 2

View References

1 

Hester CA, Dogeas E, Augustine MM, Mansour JC, Polanco PM, Porembka MR, Wang SC, Zeh HJ and Yopp A: Incidence and comparative outcomes of periampullary cancer: A population-based analysis demonstrating improved outcomes and increased use of adjuvant therapy from 2004 to 2012. J Surg Oncol. 119:303–317. 2019.PubMed/NCBI View Article : Google Scholar

2 

Ilic M and Ilic I: Epidemiology of pancreatic cancer. World J Gastroenterol. 22:9694–9705. 2016.PubMed/NCBI View Article : Google Scholar

3 

Higuera O: Management of pancreatic cancer in the elderly. World J Gastroenterol. 22:764–775. 2016.PubMed/NCBI View Article : Google Scholar

4 

Eurostat: Ageing Europe-statistics on population developments-Statistics Explained. https://ec.europa.eu/eurostat/statistics-explained/index.php?title=Ageing_Europe_-_statistics_on_population_developments. Accessed Apr 4, 2020.

5 

Eurostat: Population structure and ageing-Statistics Explained. https://ec.europa.eu/eurostat/statistics-explained/index.php/Population_structure_and_ageing. Accessed Apr 4, 2020.

6 

Wiltberger G, Krenzien F, Atanasov G, Hau HM, Schmelzle M, Bartels M and Benzing C: Pancreaticoduodenectomy for periampullary cancer: Does the tumour entity influence perioperative morbidity and long-term outcome? Acta Chir. Belg. 118:341–347. 2018.PubMed/NCBI View Article : Google Scholar

7 

Karim SAM, Abdulla KS, Abdulkarim QH and Rahim FH: The outcomes and complications of pancreaticoduodenectomy (Whipple procedure): Cross sectional study. Int J Surg. 52:383–387. 2018.PubMed/NCBI View Article : Google Scholar

8 

Cameron JL and He J: Two thousand consecutive pancreaticoduodenectomies. J Am Coll Surg. 220:530–536. 2015.PubMed/NCBI View Article : Google Scholar

9 

Pędziwiatr M, Małczakab P, Mizera M, Witowski J, Torbicz G, Major P, Pisarska M, Wysocki M, Jankowski M, Rubinkiewicz M, et al: Pancreatoduodenectomy for pancreatic head tumors in the elderly-systematic review and meta-analysis. Surg Oncol. 27:346–364. 2018.PubMed/NCBI View Article : Google Scholar

10 

Miyazaki Y, Kokudo T, Amikura K, Kageyama Y, Takahashi A, Ohkohchi N and Sakamoto H: Age does not affect complications and overall survival rate after pancreaticoduodenectomy: Single-center experience and systematic review of literature. Biosci Trends. 10:300–306. 2016.PubMed/NCBI View Article : Google Scholar

11 

Casadei R, Ricci C, Lazzarini E, Taffurelli G, D'Ambra M, Mastroroberto M, Morselli-Labate AM and Minni F: Pancreatic resection in patients 80 years or older: A meta-analysis and systematic review. Pancreas. 43:1208–1218. 2014.PubMed/NCBI View Article : Google Scholar

12 

Kim SY, Weinberg L, Christophi C and Nikfarjam M: The outcomes of pancreaticoduodenectomy in patients aged 80 or older: A systematic review and meta-analysis. HPB (Oxford). 19:475–482. 2017.PubMed/NCBI View Article : Google Scholar

13 

West H and Jin JO: Performance status in patients with cancer. JAMA Oncol. 1(998)2015.

14 

Langan RC, Huang CC, Mao WR, Harris K, Chapman W, Fehring C, Oza K, Jackson PG, Jha R, Haddad N, et al: Pancreaticoduodenectomy hospital resource utilization in octogenarians. Am J Surg. 211:70–75. 2016.PubMed/NCBI View Article : Google Scholar

15 

Liang DH, Shirkey BA, Rosenberg WR and Martinez S: Clinical outcomes of pancreaticoduodenectomy in octogenarians: A surgeon's experience from 2007 to 2015. J Gastrointest Oncol. 7:540–546. 2016.PubMed/NCBI View Article : Google Scholar

16 

Sugimachi K, Iguchi T, Mano Y, Nishijima T, Nakanoko T, Uehara H, Sugiyama M, Ohta M, Ikebe M, Morita M and Toh Y: The impact of immunonutritional and physical status on surgical outcome after pancreaticoduodenectomy in elderly patients. Anticancer Res. 39:6347–6353. 2019.PubMed/NCBI View Article : Google Scholar

17 

Oguro S, Shimada K, Kishi Y, Nara S, Esaki M and Kosuge T: Perioperative and long-term outcomes after pancreaticoduodenectomy in elderly patients 80 years of age and older. Langenbecks Arch Surg. 398:531–538. 2013.PubMed/NCBI View Article : Google Scholar

18 

Langan RC, Zheng C, Harris K, Verstraete R, Al-Refaie WB and Johnson LB: Hospital-level resource use by the oldest-old for pancreaticoduodenectomy at high-volume hospitals. Surgery. 158:366–372. 2015.PubMed/NCBI View Article : Google Scholar

19 

Melis M, Marcon F, Masi A, Pinna A, Sarpel U, Miller G, Moore H, Cohen S, Berman R, Pachter HL and Newman E: The safety of a pancreaticoduodenectomy in patients older than 80 years: Risk vs. benefits. HPB (Oxford). 14:583–588. 2012.PubMed/NCBI View Article : Google Scholar

20 

Lee DY, Schwartz JA, Wexelman B, Kirchoff D, Yang KC and Attiyeh F: Outcomes of pancreaticoduodenectomy for pancreatic malignancy in octogenarians: An American college of surgeons national surgical quality improvement program analysis. Am J Surg. 207:540–548. 2014.PubMed/NCBI View Article : Google Scholar

21 

Shiozawa S, Usui T, Kuhara K, Tsuchiya A, Miyauchi T, Kono T, Shimojima Y, Asaka S, Yamaguchi K, Yokomizo H, et al: Eligibility criteria specific to pancreaticoduodenectomy for octogenarians: Single-center opinion. Anticancer Res. 37:2037–2043. 2017.PubMed/NCBI View Article : Google Scholar

22 

Hatzaras I, Schmidt C, Klemanski D, Muscarella P, Melvin WS, Ellison EC and Bloomston M: Pancreatic resection in the octogenarian: A safe option for pancreatic malignancy. J Am Coll Surg. 212:373–377. 2011.PubMed/NCBI View Article : Google Scholar

23 

Kinoshita S, Sho M, Yanagimoto H, Satoi S, Akahori T, Nagai M, Nishiwada S, Yamamoto T, Hirooka S, Yamaki S, et al: Potential role of surgical resection for pancreatic cancer in the very elderly. Pancreatology. 15:240–246. 2015.PubMed/NCBI View Article : Google Scholar

24 

Sho M, Murakami Y, Kawai M, Motoi F, Satoi S, Matsumoto I, Honda G, Uemura K, Yanagimoto H, Kurata M, et al: Prognosis after surgical treatment for pancreatic cancer in patients aged 80 years or older: A multicenter study. J Hepatobiliary Pancreat Sci. 23:188–197. 2016.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Parasyris S, Hatzaras I, Ntella V, Sidiropoulos T, Margaris I, Pantazis N, Kokoropoulos P, Vassiliu P, Matsota P, Smyrniotis V, Smyrniotis V, et al: Pancreaticoduodenectomy as a feasible choice for periampullary malignancy in octogenarians. Mol Clin Oncol 17: 148, 2022.
APA
Parasyris, S., Hatzaras, I., Ntella, V., Sidiropoulos, T., Margaris, I., Pantazis, N. ... Arkadopoulos, N. (2022). Pancreaticoduodenectomy as a feasible choice for periampullary malignancy in octogenarians. Molecular and Clinical Oncology, 17, 148. https://doi.org/10.3892/mco.2022.2581
MLA
Parasyris, S., Hatzaras, I., Ntella, V., Sidiropoulos, T., Margaris, I., Pantazis, N., Kokoropoulos, P., Vassiliu, P., Matsota, P., Smyrniotis, V., Arkadopoulos, N."Pancreaticoduodenectomy as a feasible choice for periampullary malignancy in octogenarians". Molecular and Clinical Oncology 17.4 (2022): 148.
Chicago
Parasyris, S., Hatzaras, I., Ntella, V., Sidiropoulos, T., Margaris, I., Pantazis, N., Kokoropoulos, P., Vassiliu, P., Matsota, P., Smyrniotis, V., Arkadopoulos, N."Pancreaticoduodenectomy as a feasible choice for periampullary malignancy in octogenarians". Molecular and Clinical Oncology 17, no. 4 (2022): 148. https://doi.org/10.3892/mco.2022.2581
Copy and paste a formatted citation
x
Spandidos Publications style
Parasyris S, Hatzaras I, Ntella V, Sidiropoulos T, Margaris I, Pantazis N, Kokoropoulos P, Vassiliu P, Matsota P, Smyrniotis V, Smyrniotis V, et al: Pancreaticoduodenectomy as a feasible choice for periampullary malignancy in octogenarians. Mol Clin Oncol 17: 148, 2022.
APA
Parasyris, S., Hatzaras, I., Ntella, V., Sidiropoulos, T., Margaris, I., Pantazis, N. ... Arkadopoulos, N. (2022). Pancreaticoduodenectomy as a feasible choice for periampullary malignancy in octogenarians. Molecular and Clinical Oncology, 17, 148. https://doi.org/10.3892/mco.2022.2581
MLA
Parasyris, S., Hatzaras, I., Ntella, V., Sidiropoulos, T., Margaris, I., Pantazis, N., Kokoropoulos, P., Vassiliu, P., Matsota, P., Smyrniotis, V., Arkadopoulos, N."Pancreaticoduodenectomy as a feasible choice for periampullary malignancy in octogenarians". Molecular and Clinical Oncology 17.4 (2022): 148.
Chicago
Parasyris, S., Hatzaras, I., Ntella, V., Sidiropoulos, T., Margaris, I., Pantazis, N., Kokoropoulos, P., Vassiliu, P., Matsota, P., Smyrniotis, V., Arkadopoulos, N."Pancreaticoduodenectomy as a feasible choice for periampullary malignancy in octogenarians". Molecular and Clinical Oncology 17, no. 4 (2022): 148. https://doi.org/10.3892/mco.2022.2581
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team