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Local control after palliative external beam radiotherapy for bone metastases in patients with favorable prognosis

  • Authors:
    • Kenji Makita
    • Yasushi Hamamoto
    • Hiromitsu Kanzaki
    • Masaaki Kataoka
    • Shuhei Yamamoto
    • Kei Nagasaki
    • Hirofumi Ishikawa
    • Noriko Takata
    • Shintaro Tsuruoka
    • Kotaro Uwatsu
    • Teruhito Kido
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Ehime University Graduate School of Medicine, Toon, Ehime 791‑0295, Japan, Department of Radiation Oncology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime 791‑0280, Japan, Department of Radiology, Saiseikai Imabari Hospital, Imabari, Ehime 799‑1592, Japan
    Copyright: © Makita et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 152
    |
    Published online on: September 15, 2022
       https://doi.org/10.3892/mco.2022.2585
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Abstract

Advancement in systemic therapy has increased the importance of local control (LC) of bone metastatic sites treated with radiotherapy in intermediate‑term survivors (surviving ≥1 year). To establish individualized radiotherapy for bone metastases, factors affecting LC of bone metastases treated with traditional fractionated moderate dose palliative radiotherapy (FMRT) in intermediate‑term survivors were evaluated. Between January 2010 and December 2019, 317 lesions in 240 patients treated with FMRT for bone metastases surviving for at least 1 year and followed‑up with CT for at least 6 months were reviewed retrospectively. The median survival and radiographic follow‑up times were 24 months (range, 12‑123 months) and 20 months (range, 1‑119 months), respectively. The median FMRT dose [biologically effective dose (BED)10] was 39.0 Gy (range, 28.0‑71.7 Gy). Multivariate analysis revealed that age (≥70 years), non‑vertebral bone metastasis, bone metastasis from moderate and unfavorable primary tumor sites (esophageal, colorectal, hepatobiliary/pancreatic, kidney/ureter and sarcoma/melanoma cancers), and no administration of post‑FMRT bone‑modifying agents (BMAs) were unfavorable factors for LC of bone metastasis. The 2‑year LC rates for FMRT doses (BED10) ≤39.0 Gy and >39.0 Gy were 90 and 87%, respectively. The 2‑year LC rates of patients administered and not administered post‑FMRT antineoplastic agents (ATs) were 91 and 78%, respectively. The sites of bone metastasis and primary tumors, and post‑FMRT BMAs were factors associated with LC of bone metastasis in long‑term survivors. However, a FMRT dose (BED10) ≥39.0 Gy and post‑FMRT ATs were not significant factors.
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Copy and paste a formatted citation
Spandidos Publications style
Makita K, Hamamoto Y, Kanzaki H, Kataoka M, Yamamoto S, Nagasaki K, Ishikawa H, Takata N, Tsuruoka S, Uwatsu K, Uwatsu K, et al: Local control after palliative external beam radiotherapy for bone metastases in patients with favorable prognosis. Mol Clin Oncol 17: 152, 2022.
APA
Makita, K., Hamamoto, Y., Kanzaki, H., Kataoka, M., Yamamoto, S., Nagasaki, K. ... Kido, T. (2022). Local control after palliative external beam radiotherapy for bone metastases in patients with favorable prognosis. Molecular and Clinical Oncology, 17, 152. https://doi.org/10.3892/mco.2022.2585
MLA
Makita, K., Hamamoto, Y., Kanzaki, H., Kataoka, M., Yamamoto, S., Nagasaki, K., Ishikawa, H., Takata, N., Tsuruoka, S., Uwatsu, K., Kido, T."Local control after palliative external beam radiotherapy for bone metastases in patients with favorable prognosis". Molecular and Clinical Oncology 17.5 (2022): 152.
Chicago
Makita, K., Hamamoto, Y., Kanzaki, H., Kataoka, M., Yamamoto, S., Nagasaki, K., Ishikawa, H., Takata, N., Tsuruoka, S., Uwatsu, K., Kido, T."Local control after palliative external beam radiotherapy for bone metastases in patients with favorable prognosis". Molecular and Clinical Oncology 17, no. 5 (2022): 152. https://doi.org/10.3892/mco.2022.2585
Copy and paste a formatted citation
x
Spandidos Publications style
Makita K, Hamamoto Y, Kanzaki H, Kataoka M, Yamamoto S, Nagasaki K, Ishikawa H, Takata N, Tsuruoka S, Uwatsu K, Uwatsu K, et al: Local control after palliative external beam radiotherapy for bone metastases in patients with favorable prognosis. Mol Clin Oncol 17: 152, 2022.
APA
Makita, K., Hamamoto, Y., Kanzaki, H., Kataoka, M., Yamamoto, S., Nagasaki, K. ... Kido, T. (2022). Local control after palliative external beam radiotherapy for bone metastases in patients with favorable prognosis. Molecular and Clinical Oncology, 17, 152. https://doi.org/10.3892/mco.2022.2585
MLA
Makita, K., Hamamoto, Y., Kanzaki, H., Kataoka, M., Yamamoto, S., Nagasaki, K., Ishikawa, H., Takata, N., Tsuruoka, S., Uwatsu, K., Kido, T."Local control after palliative external beam radiotherapy for bone metastases in patients with favorable prognosis". Molecular and Clinical Oncology 17.5 (2022): 152.
Chicago
Makita, K., Hamamoto, Y., Kanzaki, H., Kataoka, M., Yamamoto, S., Nagasaki, K., Ishikawa, H., Takata, N., Tsuruoka, S., Uwatsu, K., Kido, T."Local control after palliative external beam radiotherapy for bone metastases in patients with favorable prognosis". Molecular and Clinical Oncology 17, no. 5 (2022): 152. https://doi.org/10.3892/mco.2022.2585
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