Bladder tuberculosis with ureteral strictures after bacillus Calmette‑Guérin therapy for urinary bladder cancer: A case report

Tominaga,Yusuke; Fujii,Masanori; Sadahira,Takuya; Katayama,Satoshi; Iwata,Takehiro; Nishimura,Shingo; Bekku,Kensuke; Edamura,Kohei; Kobayashi,Tomoko; Kobayashi,Yasuyuki; Kiura,Katsuyuki; Maeda,Yoshinobu; Wada,Koichiro; Araki,Motoo

doi:10.3892/mco.2022.2603

February-2023 Volume 18 Issue 2

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February-2023 Volume 18 Issue 2

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Case Report Open Access

Bladder tuberculosis with ureteral strictures after bacillus Calmette‑Guérin therapy for urinary bladder cancer: A case report

Authors:
- Yusuke Tominaga
- Masanori Fujii
- Takuya Sadahira
- Satoshi Katayama
- Takehiro Iwata
- Shingo Nishimura
- Kensuke Bekku
- Kohei Edamura
- Tomoko Kobayashi
- Yasuyuki Kobayashi
- Katsuyuki Kiura
- Yoshinobu Maeda
- Koichiro Wada
- Motoo Araki
View Affiliations / Copyright

Affiliations: Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8558, Japan, Department of Allergy and Respiratory Medicine, Okayama University Hospital, Okayama 700‑8558, Japan, Department of Urology, Shimane University Faculty of Medicine, Izumo, Shimane 693‑8501, Japan

Copyright: © Tominaga et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 7
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Published online on: December 20, 2022

https://doi.org/10.3892/mco.2022.2603
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Abstract

Intravesical immunotherapy using bacillus Calmette‑Guérin (BCG) is recommended for patients with intermediate‑ to high‑risk non‑muscle invasive bladder cancer. Bladder tuberculosis (TB) is a rare complication of BCG therapy. The present study describes the case of a 73‑year‑old man who underwent intravesical BCG therapy for urothelial carcinoma in situ of the bladder. Red patches around the resection scar were first detected 1 year and 5 months after BCG treatment; these findings gradually spread to encompass more of the bladder wall. Transurethral biopsy revealed a benign lesion, but the patient developed bilateral hydronephrosis and mild voiding dysfunction. The patient was eventually diagnosed with bladder TB by mycobacterial urine culture and TB‑specific polymerase chain reaction (PCR). The patient was given multidrug therapy (isoniazid, rifampicin and ethambutol) and their bladder TB was completely cured; however, their voiding dysfunction and bilateral hydronephrosis did not fully improve. Bladder TB can occur long after intravesical BCG administration and cystoscopy findings consistent with inflammation can be the key to suspecting this condition. Acid‑fast examination and PCR testing of a urine sample are necessary for early diagnosis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Bladder tuberculosis with ureteral strictures after bacillus Calmette‑Guérin therapy for urinary bladder cancer: A case report

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