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Epstein‑Barr virus‑associated lymphoepithelial carcinoma arising in the parotid gland: A case report and literature review

  • Authors:
    • Akinobu Kubota
    • Nobuyuki Bandoh
    • Takashi Goto
    • Ken-Ichi Matsumoto
    • Tomomi Yamaguchi-Ishochi
    • Yasutaka Kato
    • Hiroshi Nishihara
    • Hidehiro Takei
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology-Head and Neck Surgery, Hokuto Hospital, Obihiro, Hokkaido 080-0833, Japan, Department of Radiation Therapy, Hokuto Hospital, Obihiro, Hokkaido 080-0833, Japan, Department of Pathology and Genetics, Hokuto Hospital, Obihiro, Hokkaido 080-0833, Japan, Keio Cancer Center, Keio University School of Medicine, Tokyo 160-8582, Japan, Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA 71103, USA
    Copyright: © Kubota et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 24
    |
    Published online on: February 10, 2023
       https://doi.org/10.3892/mco.2023.2620
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Abstract

A 60‑year‑old woman presented with a 3‑year history of a slow‑growing, painless mass in their left parotid gland. Ultrasonography revealed a well‑circumscribed, lobulated, hypoechoic mass measuring 19x12x10 mm in the left parotid gland. Computed tomography revealed a well‑circumscribed, solid mass with homogeneous enhancement. Fluorodeoxyglucose‑positron emission tomography revealed uptake by the tumor but no uptake in other organs, including the nasopharynx. The patient underwent superficial parotidectomy with adequate safety margins and selective neck dissection followed by radiotherapy. No facial paralysis or recurrence of the tumor had been observed as of 20 months post‑operation. Histologically, the tumor was composed of sheets of syncytial cancer cells with prominent nucleoli in a dense lymphoplasmacytic background. Epstein‑Barr virus (EBV)‑encoded RNA in situ hybridization was diffusely positive in the tumor cells. These findings indicated that the tumor was an EBV‑associated lymphoepithelial carcinoma. Metastasis, especially from the nasopharynx, was excluded endoscopically and radiologically. Targeted next‑generation sequencing of 160 cancer‑related genes using the surgical specimen revealed no mutations, including known significant mutations detected in EBV‑associated nasopharyngeal carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Kubota A, Bandoh N, Goto T, Matsumoto K, Yamaguchi-Ishochi T, Kato Y, Nishihara H and Takei H: Epstein‑Barr virus‑associated lymphoepithelial carcinoma arising in the parotid gland: A case report and literature review. Mol Clin Oncol 18: 24, 2023.
APA
Kubota, A., Bandoh, N., Goto, T., Matsumoto, K., Yamaguchi-Ishochi, T., Kato, Y. ... Takei, H. (2023). Epstein‑Barr virus‑associated lymphoepithelial carcinoma arising in the parotid gland: A case report and literature review. Molecular and Clinical Oncology, 18, 24. https://doi.org/10.3892/mco.2023.2620
MLA
Kubota, A., Bandoh, N., Goto, T., Matsumoto, K., Yamaguchi-Ishochi, T., Kato, Y., Nishihara, H., Takei, H."Epstein‑Barr virus‑associated lymphoepithelial carcinoma arising in the parotid gland: A case report and literature review". Molecular and Clinical Oncology 18.3 (2023): 24.
Chicago
Kubota, A., Bandoh, N., Goto, T., Matsumoto, K., Yamaguchi-Ishochi, T., Kato, Y., Nishihara, H., Takei, H."Epstein‑Barr virus‑associated lymphoepithelial carcinoma arising in the parotid gland: A case report and literature review". Molecular and Clinical Oncology 18, no. 3 (2023): 24. https://doi.org/10.3892/mco.2023.2620
Copy and paste a formatted citation
x
Spandidos Publications style
Kubota A, Bandoh N, Goto T, Matsumoto K, Yamaguchi-Ishochi T, Kato Y, Nishihara H and Takei H: Epstein‑Barr virus‑associated lymphoepithelial carcinoma arising in the parotid gland: A case report and literature review. Mol Clin Oncol 18: 24, 2023.
APA
Kubota, A., Bandoh, N., Goto, T., Matsumoto, K., Yamaguchi-Ishochi, T., Kato, Y. ... Takei, H. (2023). Epstein‑Barr virus‑associated lymphoepithelial carcinoma arising in the parotid gland: A case report and literature review. Molecular and Clinical Oncology, 18, 24. https://doi.org/10.3892/mco.2023.2620
MLA
Kubota, A., Bandoh, N., Goto, T., Matsumoto, K., Yamaguchi-Ishochi, T., Kato, Y., Nishihara, H., Takei, H."Epstein‑Barr virus‑associated lymphoepithelial carcinoma arising in the parotid gland: A case report and literature review". Molecular and Clinical Oncology 18.3 (2023): 24.
Chicago
Kubota, A., Bandoh, N., Goto, T., Matsumoto, K., Yamaguchi-Ishochi, T., Kato, Y., Nishihara, H., Takei, H."Epstein‑Barr virus‑associated lymphoepithelial carcinoma arising in the parotid gland: A case report and literature review". Molecular and Clinical Oncology 18, no. 3 (2023): 24. https://doi.org/10.3892/mco.2023.2620
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