Open Access

AMIGO2 expression as a predictor of recurrence in cervical cancer with intermediate risk

  • Authors:
    • Yuki Iida
    • Mitsuhiko Osaki
    • Shinya Sato
    • Runa Izutsu
    • Heekyung Seong
    • Masayo Okawa
    • Daiken Osaku
    • Hiroaki Komatsu
    • Fuminori Taniguchi
    • Futoshi Okada
  • View Affiliations

  • Published online on: May 26, 2023     https://doi.org/10.3892/mco.2023.2652
  • Article Number: 56
  • Copyright: © Iida et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Patients with recurrent cervical cancer have limited treatment options and are often considered to be incurable. Since the expression of amphoterin‑induced gene and open reading frame 2 (AMIGO2) in clinical samples is a prognostic factor for colorectal cancer and gastric cancer, the present aimed to elucidate whether it is also a prognostic factor for cervical cancer. Patients with primary cervical cancer who underwent radical hysterectomy or radical trachelectomy at our institution (Faculty of Medicine, Tottori University, Yonago, Japan) between September 2005 and October 2016 were retrospectively collected. Immunohistochemical analysis using a specific antibody against AMIGO2 was performed on 101 tumor samples, and the clinical characteristics, disease‑free survival (DFS) and overall survival (OS) of the patients were examined. Patients in the AMIGO2‑high group had a shorter 5‑year DFS and OS than those in the AMIGO2‑low group (P<0.001). Furthermore, AMIGO2 was an independent prognostic factor for DFS in multivariate analysis (P=0.0012). Patients in the AMIGO2‑high group exhibited obvious recurrence compared with those in the AMIGO2‑low group in the high‑(P=0.03) and intermediate‑risk groups (P=0.003). Positive lymph node metastasis, and parametrial, stromal and lymph vascular space invasion were significantly more common in AMIGO2‑high patients. Taken together, AMIGO2 expression may be a predictive marker of recurrence for cervical cancer. In particular, it may be an indicator to determine the need for postoperative adjuvant therapy in intermediate‑risk group patients.
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July-2023
Volume 19 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Iida Y, Osaki M, Sato S, Izutsu R, Seong H, Okawa M, Osaku D, Komatsu H, Taniguchi F, Okada F, Okada F, et al: AMIGO2 expression as a predictor of recurrence in cervical cancer with intermediate risk. Mol Clin Oncol 19: 56, 2023
APA
Iida, Y., Osaki, M., Sato, S., Izutsu, R., Seong, H., Okawa, M. ... Okada, F. (2023). AMIGO2 expression as a predictor of recurrence in cervical cancer with intermediate risk. Molecular and Clinical Oncology, 19, 56. https://doi.org/10.3892/mco.2023.2652
MLA
Iida, Y., Osaki, M., Sato, S., Izutsu, R., Seong, H., Okawa, M., Osaku, D., Komatsu, H., Taniguchi, F., Okada, F."AMIGO2 expression as a predictor of recurrence in cervical cancer with intermediate risk". Molecular and Clinical Oncology 19.1 (2023): 56.
Chicago
Iida, Y., Osaki, M., Sato, S., Izutsu, R., Seong, H., Okawa, M., Osaku, D., Komatsu, H., Taniguchi, F., Okada, F."AMIGO2 expression as a predictor of recurrence in cervical cancer with intermediate risk". Molecular and Clinical Oncology 19, no. 1 (2023): 56. https://doi.org/10.3892/mco.2023.2652