Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
July-2023 Volume 19 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2023 Volume 19 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.pdf
Article Open Access

AMIGO2 expression as a predictor of recurrence in cervical cancer with intermediate risk

  • Authors:
    • Yuki Iida
    • Mitsuhiko Osaki
    • Shinya Sato
    • Runa Izutsu
    • Heekyung Seong
    • Masayo Okawa
    • Daiken Osaku
    • Hiroaki Komatsu
    • Fuminori Taniguchi
    • Futoshi Okada
  • View Affiliations / Copyright

    Affiliations: Division of Experimental Pathology, Faculty of Medicine, Tottori University, Yonago, Tottori 683‑8503, Japan, Department of Obstetrics and Gynecology, Faculty of Medicine, Tottori University, Yonago, Tottori 683‑8503, Japan
    Copyright: © Iida et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 56
    |
    Published online on: May 26, 2023
       https://doi.org/10.3892/mco.2023.2652
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Patients with recurrent cervical cancer have limited treatment options and are often considered to be incurable. Since the expression of amphoterin‑induced gene and open reading frame 2 (AMIGO2) in clinical samples is a prognostic factor for colorectal cancer and gastric cancer, the present aimed to elucidate whether it is also a prognostic factor for cervical cancer. Patients with primary cervical cancer who underwent radical hysterectomy or radical trachelectomy at our institution (Faculty of Medicine, Tottori University, Yonago, Japan) between September 2005 and October 2016 were retrospectively collected. Immunohistochemical analysis using a specific antibody against AMIGO2 was performed on 101 tumor samples, and the clinical characteristics, disease‑free survival (DFS) and overall survival (OS) of the patients were examined. Patients in the AMIGO2‑high group had a shorter 5‑year DFS and OS than those in the AMIGO2‑low group (P<0.001). Furthermore, AMIGO2 was an independent prognostic factor for DFS in multivariate analysis (P=0.0012). Patients in the AMIGO2‑high group exhibited obvious recurrence compared with those in the AMIGO2‑low group in the high‑(P=0.03) and intermediate‑risk groups (P=0.003). Positive lymph node metastasis, and parametrial, stromal and lymph vascular space invasion were significantly more common in AMIGO2‑high patients. Taken together, AMIGO2 expression may be a predictive marker of recurrence for cervical cancer. In particular, it may be an indicator to determine the need for postoperative adjuvant therapy in intermediate‑risk group patients.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021.PubMed/NCBI View Article : Google Scholar

2 

Nagase S, Ohta T, Takahashi F, Yamagami W and Yaegashi N: Board Members of the 2020 Committee on Gynecologic Oncology of the Japan Society of Obstetrics and Gynecology. Annual report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology: Annual patient report for 2018 and annual treatment report for 2013. J Obstet Gynaecol Res. 48:541–552. 2022.PubMed/NCBI View Article : Google Scholar

3 

Shigeta S, Shida M, Nagase S, Ikeda M, Takahashi F, Shibata T, Yamagami W, Katabuchi H, Yaegashi N, Aoki D and Mikami M: Epidemiological guideline influence on the therapeutic trend and patient outcome of uterine cervical cancer in Japan: Japan society of gynecologic oncology guideline evaluation committee project. Gynecol Oncol. 159:248–255. 2020.PubMed/NCBI View Article : Google Scholar

4 

Sedlis A, Bundy BN, Rotman MZ, Lentz SS, Muderspach LI and Zaino RJ: A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A Gynecologic Oncology Group Study. Gynecol Oncol. 73:177–183. 1999.PubMed/NCBI View Article : Google Scholar

5 

Ryu SY, Kim MH, Nam BH, Lee TS, Song ES, Park CY, Kim JW, Kim YB, Ryu HS, Park SY, et al: Intermediate-risk grouping of cervical cancer patients treated with radical hysterectomy: A Korean Gynecologic Oncology Group study. Br J Cancer. 110:278–285. 2014.PubMed/NCBI View Article : Google Scholar

6 

Noh JM, Park W, Kim YS, Kim JY, Kim HJ, Kim J, Kim JH, Yoon MS, Choi JH, Yoon WS, et al: Comparison of clinical outcomes of adenocarcinoma and adenosquamous carcinoma in uterine cervical cancer patients receiving surgical resection followed by radiotherapy: A multicenter retrospective study (KROG 13-10). Gynecol Oncol. 132:618–623. 2014.PubMed/NCBI View Article : Google Scholar

7 

Diaz ES, Aoyama C, Baquing MA, Beavis A, Silva E, Holschneider C and Cass I: Predictors of residual carcinoma or carcinoma-in-situ at hysterectomy following cervical conization with positive margins. Gynecol Oncol. 132:76–80. 2014.PubMed/NCBI View Article : Google Scholar

8 

Estape RE, Angioli R, Madrigal M, Janicek M, Gomez C, Penalver M and Averette H: Close vaginal margins as a prognostic factor after radical hysterectomy. Gynecol Oncol. 68:229–232. 1998.PubMed/NCBI View Article : Google Scholar

9 

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines): Cervical Cancer. Version 1. National Comprehensive Cancer Network, 2023.

10 

Tanio A, Saito H, Amisaki M, Hara K, Sugezawa K, Uejima C, Tada Y, Kihara K, Yamamoto M, Nosaka K, et al: AMIGO2 as a novel indicator of liver metastasis in patients with colorectal cancer. Oncol Lett. 21(278)2021.PubMed/NCBI View Article : Google Scholar

11 

Goto K, Morimoto M, Osaki M, Tanio A, Izutsu R, Fujiwara Y and Okada F: The impact of AMIGO2 on prognosis and hepatic metastasis in gastric cancer patients. BMC Cancer. 22(280)2022.PubMed/NCBI View Article : Google Scholar

12 

Olawaiye AB, Baker TP, Washington MK and Mutch DG: The new (Version 9) American Joint Committee on Cancer tumor, node, metastasis staging for cervical cancer. CA Cancer J Clin. 71:287–298. 2021.PubMed/NCBI View Article : Google Scholar

13 

Goto K, Osaki M, Izutsu R, Tanaka H, Sasaki R, Tanio A, Satofuka H, Kazuki Y, Yamamoto M, Kugoh H, et al: Establishment of an antibody specific for AMIGO2 improves immunohistochemical evaluation of liver metastases and clinical outcomes in patients with colorectal cancer. Diagn Pathol. 17(16)2022.PubMed/NCBI View Article : Google Scholar

14 

Kanda Y: Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 48:452–458. 2013.PubMed/NCBI View Article : Google Scholar

15 

Kanda Y, Osaki M, Onuma K, Sonoda A, Kobayashi M, Hamada J, Nicolson GL, Ochiya T and Okada F: Amigo2-upregulation in tumour cells facilitates their attachment to liver endothelial cells resulting in liver metastases. Sci Rep. 7(43567)2017.PubMed/NCBI View Article : Google Scholar

16 

Izutsu R, Osaki M, Jehung JP, Seong HK and Okada F: Liver Metastasis formation is defined by AMIGO2 expression via adhesion to hepatic endothelial cells in human gastric and colorectal cancer cells. Pathol Res Pract. 237(154015)2022.PubMed/NCBI View Article : Google Scholar

17 

Liu Y, Yang J, Shi Z, Tan X, Jin N, O'Brien C, Ott C, Grisoli A, Lee E, Volk K, et al: In vivo selection of highly metastatic human ovarian cancer sublines reveals role for AMIGO2 in intra-peritoneal metastatic regulation. Cancer Lett. 503:163–173. 2021.PubMed/NCBI View Article : Google Scholar

18 

Landoni F, Maneo A, Colombo A, Placa F, Milani R, Perego P, Favini G, Ferri L and Mangioni C: Randamised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer. Lancet. 350:535–540. 1997.PubMed/NCBI View Article : Google Scholar

19 

Shigeta S, Shimada M, Tsuji K, Nagai T, Tanase Y, Matsuo K, Kamiura S, Iwata T, Yokota H and Mikami M: Risk assessment in the patients with uterine cervical cancer harboring intermediate risk factors after radical hysterectomy: A multicenter, retrospective analysis by the Japanese Gynecologic Oncology Group. Int J Clin Oncol. 27:1507–1515. 2022.PubMed/NCBI View Article : Google Scholar

20 

Shimada M, Kigawa J, Takahashi M, Minagawa Y, Okada M, Kanamori Y, Itamochi H, Oishi T, Iba T and Terakawa N: Stromal invasion of the cervix can be excluded from the criteria for using adjuvant radiotherapy following radical surgery for patients with cervical cancer. Gynecol Oncol. 93:628–631. 2004.PubMed/NCBI View Article : Google Scholar

21 

Osaku D, Komatsu H, Okawa M, Iida Y, Sato S, Oishi T and Harada T: Re-classification of uterine cervical cancer cases treated with radical hysterectomy based on the 2018 FIGO staging system. Taiwan J Obstet Gynecol. 60:1054–1058. 2021.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Iida Y, Osaki M, Sato S, Izutsu R, Seong H, Okawa M, Osaku D, Komatsu H, Taniguchi F, Okada F, Okada F, et al: AMIGO2 expression as a predictor of recurrence in cervical cancer with intermediate risk. Mol Clin Oncol 19: 56, 2023.
APA
Iida, Y., Osaki, M., Sato, S., Izutsu, R., Seong, H., Okawa, M. ... Okada, F. (2023). AMIGO2 expression as a predictor of recurrence in cervical cancer with intermediate risk. Molecular and Clinical Oncology, 19, 56. https://doi.org/10.3892/mco.2023.2652
MLA
Iida, Y., Osaki, M., Sato, S., Izutsu, R., Seong, H., Okawa, M., Osaku, D., Komatsu, H., Taniguchi, F., Okada, F."AMIGO2 expression as a predictor of recurrence in cervical cancer with intermediate risk". Molecular and Clinical Oncology 19.1 (2023): 56.
Chicago
Iida, Y., Osaki, M., Sato, S., Izutsu, R., Seong, H., Okawa, M., Osaku, D., Komatsu, H., Taniguchi, F., Okada, F."AMIGO2 expression as a predictor of recurrence in cervical cancer with intermediate risk". Molecular and Clinical Oncology 19, no. 1 (2023): 56. https://doi.org/10.3892/mco.2023.2652
Copy and paste a formatted citation
x
Spandidos Publications style
Iida Y, Osaki M, Sato S, Izutsu R, Seong H, Okawa M, Osaku D, Komatsu H, Taniguchi F, Okada F, Okada F, et al: AMIGO2 expression as a predictor of recurrence in cervical cancer with intermediate risk. Mol Clin Oncol 19: 56, 2023.
APA
Iida, Y., Osaki, M., Sato, S., Izutsu, R., Seong, H., Okawa, M. ... Okada, F. (2023). AMIGO2 expression as a predictor of recurrence in cervical cancer with intermediate risk. Molecular and Clinical Oncology, 19, 56. https://doi.org/10.3892/mco.2023.2652
MLA
Iida, Y., Osaki, M., Sato, S., Izutsu, R., Seong, H., Okawa, M., Osaku, D., Komatsu, H., Taniguchi, F., Okada, F."AMIGO2 expression as a predictor of recurrence in cervical cancer with intermediate risk". Molecular and Clinical Oncology 19.1 (2023): 56.
Chicago
Iida, Y., Osaki, M., Sato, S., Izutsu, R., Seong, H., Okawa, M., Osaku, D., Komatsu, H., Taniguchi, F., Okada, F."AMIGO2 expression as a predictor of recurrence in cervical cancer with intermediate risk". Molecular and Clinical Oncology 19, no. 1 (2023): 56. https://doi.org/10.3892/mco.2023.2652
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team