Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
November-2023 Volume 19 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2023 Volume 19 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.pdf
Article Open Access

Development of a clinical scoring model to predict the overall and relapse‑free survival of patients with hepatocellular carcinoma following a hepatectomy

  • Authors:
    • Wanyu Deng
    • Fu Chen
    • Yuanxiang Li
    • Leibo Xu
  • View Affiliations / Copyright

    Affiliations: College of Life Science, Shangrao Normal University, Shangrao, Jiangxi 334001, P.R. China, Department of Pancreato‑Biliary Surgery, Sun Yat‑Sen Memorial Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510120, P.R. China
    Copyright: © Deng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 87
    |
    Published online on: September 21, 2023
       https://doi.org/10.3892/mco.2023.2683
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Hepatocellular carcinoma (HCC) is a highly lethal disease, and surgical resection is one of the major treatment methods used. However, to date, at least to the best of our knowledge, there is no effective prognostic scoring system for the overall survival (OS) and relapse‑free survival (RFS) of patients following hepatectomy. The present study developed a low‑cost and easy‑to‑use model based on the clinicopathological characteristics of patients with HCC for assessment of outcome prediction and risk stratification. A total of 690 patients with HCC undergoing surgery were included and randomly divided into two cohorts (n=345). Cox regression analysis was conducted to investigate the association between the clinicopathological and treatment features, and patient survival. Multivariate analysis revealed that ascites, vascular tumor thrombus, low tumor differentiation and extrahepatic metastasis were independent risk factors for OS. Extrahepatic metastasis and multiple tumors were independent risk factors to predict tumor recurrence. These variables were weighted to construct the ascites, vascular tumor thrombus, low tumor differentiation, extrahepatic metastasis and multiple tumors (AVLEM) score based on the cumulative incidence (CuI) of the aforementioned variables, and the patients were classified into grade 0 (CuI=0), grade 1 (CuI=1 for OS and CuI ≥1 for RFS), and grade 2 (CuI ≥2) subgroups, respectively. Kaplan‑Meier analysis revealed that the OS and RFS differed significantly among the subgroups; however, the survival rate between the two cohorts did not exhibit any marked differences. On the whole, the present study demonstrates that with this AVLEM scoring system, patients with HCC with a high score had a poor OS and RFS; thus, it is suggested that such patients undergo imaging examinations following a hepatectomy more frequently.
View Figures

Figure 1

Figure 2

View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021.PubMed/NCBI View Article : Google Scholar

2 

Zhang CH, Cheng Y, Zhang S, Fan J and Gao Q: Changing epidemiology of hepatocellular carcinoma in Asia. Liver Int. 42:2029–2041. 2022.PubMed/NCBI View Article : Google Scholar

3 

Tang Y, Xu L, Ren Y, Li Y, Yuan F, Cao M, Zhang Y, Deng M and Yao Z: Identification and validation of a prognostic model based on three MVI-related genes in hepatocellular carcinoma. Int J Biol Sci. 18:261–275. 2022.PubMed/NCBI View Article : Google Scholar

4 

Liu R, Wang G, Zhang C and Bai DS: A prognostic model for hepatocellular carcinoma based on apoptosis-related genes. World J Surg Oncol. 19(70)2021.PubMed/NCBI View Article : Google Scholar

5 

Deng FW, Chen D, Wei X, Lu S, Luo X, He J, Liu J, Meng T, Yang A and Chen H: Development and validation of a prognostic classifier based on HIF-1 signaling for hepatocellular carcinoma. Aging (Albany NY). 12:3431–3450. 2020.PubMed/NCBI View Article : Google Scholar

6 

Huang T, Yan T, Chen G and Zhang C: Development and validation of a gene mutation-associated nomogram for hepatocellular carcinoma patients from four countries. Front Genet. 12(714639)2021.PubMed/NCBI View Article : Google Scholar

7 

Li Y, Wu J, Li E, Xiao Z, Lei J, Zhou F, Yin X, Hu D, Mao Y, Wu L and Wenjun L: TP53 mutation detected in circulating exosomal DNA is associated with prognosis of patients with hepatocellular carcinoma. Cancer Biol Ther. 23:439–445. 2022.PubMed/NCBI View Article : Google Scholar

8 

Zhou J, Sun HC, Wang Z, Cong WM, Wang JH, Zeng MS, Yang JM, Bie P, Liu LX, Wen TF, et al: Guidelines for diagnosis and treatment of primary liver cancer in China (2017 Edition). Liver Cancer. 7:235–260. 2018.PubMed/NCBI View Article : Google Scholar

9 

Chen ZY, Lusicic A, O'Brien TJ, Velakoulis D, Adams SJK and Kwan P: Psychotic disorders induced by antiepileptic drugs in people with epilepsy. Brain. 139:2668–2678. 2016.PubMed/NCBI View Article : Google Scholar

10 

Yin H, Zhou W, Meng J, Zhang D, Wu Z, Wang T, Wang J, Wang P, Shi X, Wu S, et al: Prognostic factors of patients with spinal chondrosarcoma: A retrospective analysis of 98 consecutive patients in a single center. Ann Surg Oncol. 21:3572–3578. 2014.PubMed/NCBI View Article : Google Scholar

11 

Elfadaly AN, Tsilimigras DI, Hyer JM, Paro A, Bagante F, Ratti F, Marques HP, Soubrane O, Lam V, Poultsides GA, et al: Impact of tumor burden score on conditional survival after curative-intent resection for hepatocellular carcinoma: A multi-institutional analysis. World J Surg. 45:3438–3448. 2021.PubMed/NCBI View Article : Google Scholar

12 

Mgaieth S, Kemp W, Gow P, Fink M, Lubel J, Nicoll A, Gazzola A, Hong T, Ryan M, Knight V, et al: Impact of viral hepatitis aetiology on survival outcomes in hepatocellular carcinoma: A large multicentre cohort study. J Viral Hepat. 24:982–989. 2017.PubMed/NCBI View Article : Google Scholar

13 

Kumada T, Toyoda H, Tada T, Yasuda S and Tanaka J: Changes in background liver function in patients with hepatocellular carcinoma over 30 years: Comparison of child-pugh classification and albumin bilirubin grade. Liver Cancer. 9:518–528. 2020.PubMed/NCBI View Article : Google Scholar

14 

Pham L, Kyritsi K, Zhou T, Ceci L, Baiocchi L, Kennedy L, Chakraborty S, Glaser S, Francis H, Alpini G and Sato K: The functional roles of immune cells in primary liver cancer. Am J Pathol. 192:826–836. 2022.PubMed/NCBI View Article : Google Scholar

15 

Vigano L, Conci S, Cescon M, Fava C, Capelli P, D'Errico A, Torzilli G, Di Tommaso L, Giuliante F, Vecchio FM, et al: Liver resection for hepatocellular carcinoma in patients with metabolic syndrome: A multicenter matched analysis with HCV-related HCC. J Hepatol. 63:93–101. 2015.PubMed/NCBI View Article : Google Scholar

16 

Zheng Y, Liu Y, Zhao S, Zheng Z, Shen C, An L and Yuan Y: Large-scale analysis reveals a novel risk score to predict overall survival in hepatocellular carcinoma. Cancer Manag Res. 10:6079–6096. 2018.PubMed/NCBI View Article : Google Scholar

17 

de Lima LT, Broszczak D, Zhang X, Bridle K, Crawford D and Punyadeera C: The use of minimally invasive biomarkers for the diagnosis and prognosis of hepatocellular carcinoma. Biochim Biophys Acta Rev Cancer. 1874(188451)2020.PubMed/NCBI View Article : Google Scholar

18 

Zhang XF, Zhang D, Bu XF, Zhang XH and Cui L: Identification of a novel miRNA-based recurrence and prognosis prediction biomarker for hepatocellular carcinoma. BMC Bioinformatics. 23(479)2022.PubMed/NCBI View Article : Google Scholar

19 

Harimoto N, Yoshizumi T, Inokuchi S, Itoh S, Adachi E, Ikeda Y, Uchiyama H, Utsunomiya T, Kajiyama K, Kimura K, et al: Prognostic significance of preoperative controlling nutritional status (CONUT) score in patients undergoing hepatic resection for hepatocellular carcinoma: A multi-institutional study. Ann Surg Oncol. 25:3316–3323. 2018.PubMed/NCBI View Article : Google Scholar

20 

Takagi K, Yagi T, Umeda Y, Shinoura S, Yoshida R, Nobuoka D, Kuise T, Araki H and Fujiwara T: Preoperative controlling nutritional status (CONUT) score for assessment of prognosis following hepatectomy for hepatocellular carcinoma. World J Surg. 41:2353–2360. 2017.PubMed/NCBI View Article : Google Scholar

21 

Kaibori M, Sakai K, Matsushima H, Kosaka H, Matsui K, De Velasco MA, Sekimoto M and Nishio K: Patients with polyclonal hepatocellular carcinoma are at a high risk of early recurrence and have a poor recurrence-free survival period. Hepatol Int. 16:135–147. 2022.PubMed/NCBI View Article : Google Scholar

22 

Erstad DJ and Tanabe KK: Prognostic and therapeutic implications of microvascular invasion in hepatocellular carcinoma. Ann Surg Oncol. 26:1474–1493. 2019.PubMed/NCBI View Article : Google Scholar

23 

Imamura H, Matsuyama Y, Tanaka E, Ohkubo T, Hasegawa K, Miyagawa S, Sugawara Y, Minagawa M, Takayama T, Kawasaki S and Makuuchi M: Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy. J Hepatol. 38:200–207. 2003.PubMed/NCBI View Article : Google Scholar

24 

Sonohara F, Yamada S, Tanaka N, Suenaga M, Takami H, Hayashi M, Niwa Y, Sugimoto H, Hattori N, Kanda M, et al: Perioperative and prognostic implication of albumin-bilirubin-TNM score in Child-Pugh class A hepatocellular carcinoma. Ann Gastroenterol Surg. 3:65–74. 2019.PubMed/NCBI View Article : Google Scholar

25 

Liang BY, Gu J, Xiong M, Zhang EL, Zhang ZY, Chen XP and Huang ZY: Tumor size may influence the prognosis of solitary hepatocellular carcinoma patients with cirrhosis and without macrovascular invasion after hepatectomy. Sci Rep. 11(16343)2021.PubMed/NCBI View Article : Google Scholar

26 

He HL, Wang Q, Liu L, Luo NB, Su DK and Jin GQ: Peritumoral edema in preoperative magnetic resonance imaging is an independent prognostic factor for hepatocellular carcinoma. Clin Imaging. 75:143–149. 2021.PubMed/NCBI View Article : Google Scholar

27 

Hao S, Fan P, Chen S, Tu C and Wan C: Distinct recurrence risk factors for intrahepatic metastasis and multicenter occurrence after surgery in patients with hepatocellular carcinoma. J Gastrointest Surg. 21:312–320. 2017.PubMed/NCBI View Article : Google Scholar

28 

Yang T, Lu JH, Zhai J, Lin C, Yang GS, Zhao RH, Shen F and Wu MC: High viral load is associated with poor overall and recurrence-free survival of hepatitis B virus-related hepatocellular carcinoma after curative resection: A prospective cohort study. Eur J Surg Oncol. 38:683–691. 2012.PubMed/NCBI View Article : Google Scholar

29 

Huang G, Lai EC, Lau WY, Zhou WP, Shen F, Pan ZY, Fu SY and Wu MC: Posthepatectomy HBV reactivation in hepatitis B-related hepatocellular carcinoma influences postoperative survival in patients with preoperative low HBV-DNA levels. Ann Surg. 257:490–505. 2013.PubMed/NCBI View Article : Google Scholar

30 

Yoo S, Kim JY, Lim YS, Han S and Choi J: Impact of HBsAg seroclearance on late recurrence of hepatitis B virus-related hepatocellular carcinoma after surgical resection. J Hepatol. 77:939–946. 2022.PubMed/NCBI View Article : Google Scholar

31 

Huang G, Li PP, Lau WY, Pan ZY, Zhao LH, Wang ZG, Wang MC and Zhou WP: Antiviral therapy reduces hepatocellular carcinoma recurrence in patients with low HBV-DNA levels: A randomized controlled trial. Ann Surg. 268:943–954. 2018.PubMed/NCBI View Article : Google Scholar

32 

Chong CC, Wong GL, Wong VW, Ip PC, Cheung YS, Wong J, Lee KF, Lai PB and Chan HL: Antiviral therapy improves post-hepatectomy survival in patients with hepatitis B virus-related hepatocellular carcinoma: A prospective-retrospective study. Aliment Pharmacol Ther. 41:199–208. 2015.PubMed/NCBI View Article : Google Scholar

33 

Yang HI, Tseng TC, Liu J, Lee MH, Liu CJ, Su TH, Batrla-Utermann R, Chan HL, Kao JH and Chen CJ: Incorporating serum level of hepatitis B surface antigen or omitting level of hepatitis B virus DNA does not affect calculation of risk for hepatocellular carcinoma in patients without cirrhosis. Clin Gastroenterol Hepatol. 14:461–468, e462. 2016.PubMed/NCBI View Article : Google Scholar

34 

Yamashita Y, Imai D, Bekki Y, Kimura K, Matsumoto Y, Nakagawara H, Ikegami T, Yoshizumi T, Shirabe K, Aishima S and Maehara Y: Surgical outcomes of hepatic resection for hepatitis b virus surface antigen-negative and hepatitis C virus antibody-negative hepatocellular carcinoma. Ann Surg Oncol. 22:2279–2285. 2015.PubMed/NCBI View Article : Google Scholar

35 

Chen JD, Liu CJ, Lee PH, Chen PJ, Lai MY, Kao JH and Chen DS: Hepatitis B genotypes correlate with tumor recurrence after curative resection of hepatocellular carcinoma. Clin Gastroenterol Hepatol. 2:64–71. 2004.PubMed/NCBI View Article : Google Scholar

36 

Choi J, Jo C and Lim YS: Tenofovir versus entecavir on recurrence of hepatitis B virus-related hepatocellular carcinoma after surgical resection. Hepatology. 73:661–673. 2021.PubMed/NCBI View Article : Google Scholar

37 

He L, Xia Z, Shen J, Zhang X, Peng W, Li C and Wen T: The different effects of adefovir dipivoxil and telbivudine on the prognosis of hepatitis b virus-related hepatocellular carcinoma patients after curative resection. Medicine (Baltimore). 98(e14386)2019.PubMed/NCBI View Article : Google Scholar

38 

Qi W, Shen J, Dai J, Wu Y, Zhang Y, Leng S, Gao F, Ran S, Peng W, Zhang X, et al: Comparison of nucleoside and nucleotide analogs in the recurrence of hepatitis B virus-related hepatocellular carcinoma after surgical resection: A multicenter study. Cancer Med. 10:8421–8431. 2021.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Deng W, Chen F, Li Y and Xu L: Development of a clinical scoring model to predict the overall and relapse‑free survival of patients with hepatocellular carcinoma following a hepatectomy. Mol Clin Oncol 19: 87, 2023.
APA
Deng, W., Chen, F., Li, Y., & Xu, L. (2023). Development of a clinical scoring model to predict the overall and relapse‑free survival of patients with hepatocellular carcinoma following a hepatectomy. Molecular and Clinical Oncology, 19, 87. https://doi.org/10.3892/mco.2023.2683
MLA
Deng, W., Chen, F., Li, Y., Xu, L."Development of a clinical scoring model to predict the overall and relapse‑free survival of patients with hepatocellular carcinoma following a hepatectomy". Molecular and Clinical Oncology 19.5 (2023): 87.
Chicago
Deng, W., Chen, F., Li, Y., Xu, L."Development of a clinical scoring model to predict the overall and relapse‑free survival of patients with hepatocellular carcinoma following a hepatectomy". Molecular and Clinical Oncology 19, no. 5 (2023): 87. https://doi.org/10.3892/mco.2023.2683
Copy and paste a formatted citation
x
Spandidos Publications style
Deng W, Chen F, Li Y and Xu L: Development of a clinical scoring model to predict the overall and relapse‑free survival of patients with hepatocellular carcinoma following a hepatectomy. Mol Clin Oncol 19: 87, 2023.
APA
Deng, W., Chen, F., Li, Y., & Xu, L. (2023). Development of a clinical scoring model to predict the overall and relapse‑free survival of patients with hepatocellular carcinoma following a hepatectomy. Molecular and Clinical Oncology, 19, 87. https://doi.org/10.3892/mco.2023.2683
MLA
Deng, W., Chen, F., Li, Y., Xu, L."Development of a clinical scoring model to predict the overall and relapse‑free survival of patients with hepatocellular carcinoma following a hepatectomy". Molecular and Clinical Oncology 19.5 (2023): 87.
Chicago
Deng, W., Chen, F., Li, Y., Xu, L."Development of a clinical scoring model to predict the overall and relapse‑free survival of patients with hepatocellular carcinoma following a hepatectomy". Molecular and Clinical Oncology 19, no. 5 (2023): 87. https://doi.org/10.3892/mco.2023.2683
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team