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Impact of digital positron emission tomography/computed tomography on the delineation of clinical target volume in advanced lung cancer

  • Authors:
    • Kenji Makita
    • Yasushi Hamamoto
    • Hiromitsu Kanzaki
    • Kei Nagasaki
    • Masao Miyagawa
    • Naoto Kawaguchi
    • Tomohisa Okada
    • Teruhito Kido
    • Toshiyuki Kozuki
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime 791‑0280, Japan, Department of Radiology, Ehime University Graduate School of Medicine, Toon, Ehime 791‑0295, Japan, Department of Thoracic Oncology and Medicine, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime 791‑0280, Japan
    Copyright: © Makita et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 102
    |
    Published online on: November 6, 2023
       https://doi.org/10.3892/mco.2023.2698
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Abstract

The present study investigated the differences between digital [18F]‑Fluorodeoxyglucose (FDG) positron emission tomography [PET]/computed tomography [CT] (dPET/CT) and conventional PET/CT (cPET/CT) in delineating the clinical target volume (CTV) in patients with advanced lung cancer in the involved field radiation therapy (IFRT) era. Patients with advanced lung cancer were scanned using two dual‑imaging protocols (dPET/CT and cPET/CT). Two virtual delineations contoured with reference to dPET/CT and cPET/CT images were created for each patient by five radiation oncologists. Changes in the delineation of target volumes in each patient were examined. A total of 10 patients [male/female, 9/1; median age, 65 years (range, 58‑80 years)] were enrolled between April 2020 and September 2020. Significant changes in the delineation of CTVs were uncommon between dPET/CT and cPET/CT. A notable increase in CTVn was observed in 10% of the patients (1/10; P<0.05; Smirnov‑Grubbs analysis). In this patient, a node that was not assessed as lymph node metastasis when cPET/CT was used was assessed as lymph node metastasis when dPET/CT was used and was included in the CTVn by all five radiation oncologists. In patients with advanced lung cancer, notable changes in CTV delineations are uncommon, regardless of whether dPET/CT or cPET/CT is used. However, in some cases, CTVn delineation with reference to dPET/CT may improve the treatment outcomes of IFRT for advanced lung cancer.
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1 

Aupérin A, Le Péchoux C, Rolland E, Curran WJ, Furuse K, Fournel P, Belderbos J, Clamon G, Ulutin HC, Paulus R, et al: Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer. J Clin Oncol. 28:2181–2190. 2010.PubMed/NCBI View Article : Google Scholar

2 

Topkan E, Ozdemir Y, Guler OC, Kucuk A, Besen AA, Mertsoylu H, Sezen D, Akdemir EY, Sezer A, Bolukbasi Y, et al: Comparison of involved field radiotherapy versus elective nodal irradiation in stage IIIB/C non-small-cell lung carcinoma patients treated with concurrent chemoradiotherapy: A propensity score matching study. J Oncol. 2020(7083149)2020.PubMed/NCBI View Article : Google Scholar

3 

Abe T, Iino M, Saito S, Aoshika T, Ryuno Y, Ohta T, Igari M, Hirai R, Kumazaki Y, Miura Y, et al: Feasibility of intensity modulated radiotherapy with involved field radiotherapy for Japanese patients with locally advanced non-small cell lung cancer. J Radiat Res. 62:894–900. 2021.PubMed/NCBI View Article : Google Scholar

4 

Yuan S, Sun X, Li M, Yu J, Ren R, Yu Y, Li J, Liu X, Wang R, Li B, et al: A randomized study of involved-field irradiation versus elective nodal irradiation in combination with concurrent chemotherapy for inoperable stage III nonsmall cell lung cancer. Am J Clin Oncol. 30:239–244. 2007.PubMed/NCBI View Article : Google Scholar

5 

Konert T, Vogel W, MacManus MP, Nestle U, Belderbos J, Grégoire V, Thorwarth D, Fidarova E, Paez D, Chiti A and Hanna GG: PET/CT imaging for target volume delineation in curative intent radiotherapy of non-small cell lung cancer: IAEA consensus report 2014. Radiother Oncol. 116:27–34. 2015.PubMed/NCBI View Article : Google Scholar

6 

Shiga T, Morimoto Y, Kubo N, Katoh N, Katoh C, Takeuchi W, Usui R, Hirata K, Kojima S, Umegaki K, et al: A new PET scanner with semiconductor detectors enables better identification of intratumoral inhomogeneity. J Nucl Med. 50:148–155. 2009.PubMed/NCBI View Article : Google Scholar

7 

Nguyen NC, Vercher-Conejero JL, Sattar A, Miller MA, Maniawski PJ, Jordan DW, Muzic RF Jr, Su KH, O'Donnell JK and Faulhaber PF: Image quality and diagnostic performance of a digital PET prototype in patients with oncologic diseases: Initial experience and comparison with analog PET. J Nucl Med. 56:1378–1385. 2015.PubMed/NCBI View Article : Google Scholar

8 

Koopman D, van Dalen JA, Stevens H, Slump CH, Knollema S and Jager PL: Performance of digital PET compared with high-resolution conventional PET in patients with cancer. J Nucl Med. 61:1448–1454. 2020.PubMed/NCBI View Article : Google Scholar

9 

López-Mora DA, Carrió I and Flotats A: Digital PET vs analog PET: Clinical implications? Semin Nucl Med. 52:302–311. 2022.PubMed/NCBI View Article : Google Scholar

10 

Kanda Y: Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 48:452–458. 2013.PubMed/NCBI View Article : Google Scholar

11 

Grubbs FE: Sample criteria for testing outlying observations. Ann Math Statist. 21:27–58. 1950.

12 

Laurans M, Botticella A, Moukasse Y, Lévy A and Le Péchoux C: Lung cancer and elective nodal irradiation: A solved issue? Cancer Radiother. 23:701–707. 2019.PubMed/NCBI View Article : Google Scholar : (In French).

13 

Wang L, Zhang M, Pan X, Zhao M, Huang L, Hu X, Wang X, Qiao L, Guo Q, Xu W, et al: Integrative serum metabolic fingerprints based multi-modal platforms for lung adenocarcinoma early detection and pulmonary nodule classification. Adv Sci (Weinh). 9(e2203786)2022.PubMed/NCBI View Article : Google Scholar

14 

Li Y, Bao Q, Yang S, Yang M and Mao C: Bionanoparticles in cancer imaging, diagnosis, and treatment. VIEW. 3(20200027)2022.

15 

Huang J, Bao H, Li X and Zhang Z: In vivo CT imaging tracking of stem cells labeled with Au nanoparticles. VIEW. 3(20200119)2021.

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Copy and paste a formatted citation
Spandidos Publications style
Makita K, Hamamoto Y, Kanzaki H, Nagasaki K, Miyagawa M, Kawaguchi N, Okada T, Kido T and Kozuki T: Impact of digital positron emission tomography/computed tomography on the delineation of clinical target volume in advanced lung cancer. Mol Clin Oncol 19: 102, 2023.
APA
Makita, K., Hamamoto, Y., Kanzaki, H., Nagasaki, K., Miyagawa, M., Kawaguchi, N. ... Kozuki, T. (2023). Impact of digital positron emission tomography/computed tomography on the delineation of clinical target volume in advanced lung cancer. Molecular and Clinical Oncology, 19, 102. https://doi.org/10.3892/mco.2023.2698
MLA
Makita, K., Hamamoto, Y., Kanzaki, H., Nagasaki, K., Miyagawa, M., Kawaguchi, N., Okada, T., Kido, T., Kozuki, T."Impact of digital positron emission tomography/computed tomography on the delineation of clinical target volume in advanced lung cancer". Molecular and Clinical Oncology 19.6 (2023): 102.
Chicago
Makita, K., Hamamoto, Y., Kanzaki, H., Nagasaki, K., Miyagawa, M., Kawaguchi, N., Okada, T., Kido, T., Kozuki, T."Impact of digital positron emission tomography/computed tomography on the delineation of clinical target volume in advanced lung cancer". Molecular and Clinical Oncology 19, no. 6 (2023): 102. https://doi.org/10.3892/mco.2023.2698
Copy and paste a formatted citation
x
Spandidos Publications style
Makita K, Hamamoto Y, Kanzaki H, Nagasaki K, Miyagawa M, Kawaguchi N, Okada T, Kido T and Kozuki T: Impact of digital positron emission tomography/computed tomography on the delineation of clinical target volume in advanced lung cancer. Mol Clin Oncol 19: 102, 2023.
APA
Makita, K., Hamamoto, Y., Kanzaki, H., Nagasaki, K., Miyagawa, M., Kawaguchi, N. ... Kozuki, T. (2023). Impact of digital positron emission tomography/computed tomography on the delineation of clinical target volume in advanced lung cancer. Molecular and Clinical Oncology, 19, 102. https://doi.org/10.3892/mco.2023.2698
MLA
Makita, K., Hamamoto, Y., Kanzaki, H., Nagasaki, K., Miyagawa, M., Kawaguchi, N., Okada, T., Kido, T., Kozuki, T."Impact of digital positron emission tomography/computed tomography on the delineation of clinical target volume in advanced lung cancer". Molecular and Clinical Oncology 19.6 (2023): 102.
Chicago
Makita, K., Hamamoto, Y., Kanzaki, H., Nagasaki, K., Miyagawa, M., Kawaguchi, N., Okada, T., Kido, T., Kozuki, T."Impact of digital positron emission tomography/computed tomography on the delineation of clinical target volume in advanced lung cancer". Molecular and Clinical Oncology 19, no. 6 (2023): 102. https://doi.org/10.3892/mco.2023.2698
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