Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
August-2024 Volume 21 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2024 Volume 21 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Cytological features of a lymphoepithelial cyst of the salivary gland with application of the second edition of Milan System for Reporting Salivary Gland Cytopathology 

  • Authors:
    • Mitsuaki Ishida
    • Isako Kataoka
    • Mari Tomiuka
    • Hiroyuki Okanishi
    • Kozue Ariga
    • Mayumi Uragami
    • Chihiro Deguchi
    • Shizuka Ono
    • Reika Takeda
    • Yoshinobu Hirose
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka 569‑8686, Japan
    Copyright: © Ishida et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 52
    |
    Published online on: June 5, 2024
       https://doi.org/10.3892/mco.2024.2750
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Lymphoepithelial cysts (LECs) of the salivary glands are relatively rare, benign cystic lesions. Characteristic histopathological features of LEC include presence of well‑circumscribed unilocular cysts surrounded by dense lymphoid tissue with lymphoid follicles. These cysts are lined by a combination of squamous, ciliated, columnar and mucous epithelia. Fine‑needle aspiration (FNA) cytology is the standard preoperative diagnostic procedure for salivary gland lesions. Although the cytological diagnosis of cystic salivary gland lesions is difficult, the use of Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) in the cytodiagnosis of cystic salivary gland lesions has been reported. However, only a few studies have described the cytological features of LEC. To the best of our knowledge, the present study reviewed the cytological features of a case series of LEC and evaluated the application of MSRSGC for the first time. This retrospective study included 13 patients with LEC of the salivary glands who underwent pre‑operative FNA followed by surgical resection of the cyst. All the lesions were present in the parotid gland. Cytological analysis revealed no epithelial cell component in eight patients (62.5%) along with a proteinaceous background containing lymphocytes and/or foamy cells. Non‑keratinising squamous epithelium was observed in three patients. Amylase crystalloids were noted in two patients. None of the patients were cytodiagnosed with LEC. Eight, three, one and one patients were categorised as MSRSGC I, II, III, and IVa, respectively. The results of the present study demonstrated that cytodiagnosis of LEC was difficult due to the absence of epithelial component in 62.5% of the specimens. However, evaluation of its benignity was not difficult. Thus, it can be summarized that MSRSGC may be useful for cytological evaluation of LECs.
View Figures

Figure 1

Figure 2

View References

1 

Joshi J, Shah S, Agarwal D and Khasgiwal A: Benign lymphoepithelial cyst of parotid gland: Review and case report. J Oral Maxillofac Pathol. 22:S91–S97. 2018.PubMed/NCBI View Article : Google Scholar

2 

Wu L, Cheng J, Maruyama S, Yamazaki M, Tsuneki M, Lu Y, He Z, Zheng Y, Zhou Z and Saku T: Lymphoepithelial cyst of the parotid gland: Its possible histopathogenesis based on clinicopathologic analysis of 64 cases. Hum Pathol. 40:683–692. 2009.PubMed/NCBI View Article : Google Scholar

3 

Schmidt RL, Hall BJ, Wilson AR and Layfield LJ: A systematic review and meta-analysis of the diagnostic accuracy of fine-needle aspiration cytology for parotid gland lesions. Am J Clin Pathol. 136:45–59. 2011.PubMed/NCBI View Article : Google Scholar

4 

Eytan DF, Yin LX, Maleki Z, Koch WM, Tufano RP, Eisele DW, Boahene KDO, Fakhry C, Bishop JA, Westra WH and Gourin CG: Utility of preoperative fine needle aspiration in parotid lesions. Laryngoscope. 128:398–402. 2018.PubMed/NCBI View Article : Google Scholar

5 

Faquin WC, Rossi ES, Baloch Z, Barkan GA, Foschini MP, Kurtycz DF, Pusztaszeri M and Vielh P (eds): The Milan System for Reporting Salivary Gland Cytopathology. Springer International Publishing AG, Switzerland, 2018.

6 

Tochtermann G, Nowack M, Hagen C, Rupp NJ, Ikenberg K, Broglie MA, Saro F, Lenggenhager D and Bode PK: The Milan system for reporting salivary gland cytopathology-A single-center study of 2156 cases. Cancer Med. 12:12198–12207. 2023.PubMed/NCBI View Article : Google Scholar

7 

Higuchi K, Urano M, Akiba J, Nogami M, Hirata Y, Zukeran Y, Moriyoshi K, Tada Y, Fukushima M, Obayashi M, et al: A multi-institutional study of salivary gland cytopathology: Application of the Milan system for reporting salivary gland cytopathology in Japan. Cancer Cytopathol. 130:30–40. 2022.PubMed/NCBI View Article : Google Scholar

8 

Shahi AK, Sharma S, Singh B, Tandon A, Kumar A and Chandra S: Assessment of risk of malignancy of fine-needle aspiration cytology in salivary gland lesions using the milan system for reporting salivary gland cytopathology categorization: A systematic review and meta-analysis. J Contemp Dent Pract. 23:1039–1056. 2022.PubMed/NCBI View Article : Google Scholar

9 

Velez Torres JM, Tjendra Y, Zuo Y, Garcia-Buitrago M, Jorda M, Kerr DA and Gomez-Fernandez CR: Application of the milan system for reporting salivary gland cytopathology: A single institutional experience of 354 cases with cytologic-histologic correlation. Acta Cytol. 66:467–474. 2022.PubMed/NCBI View Article : Google Scholar

10 

Jalaly JB, Farahani SJ and Baloch ZW: The Milan system for reporting salivary gland cytopathology: A comprehensive review of the literature. Diagn Cytopathol. 48:880–889. 2020.PubMed/NCBI View Article : Google Scholar

11 

Maleki Z, Baloch Z, Lu R, Shafique K, Song SJ, Viswanathan K, Rao RA, Lefler H, Fatima A, Wiles A, et al: Application of the milan system for reporting submandibular gland cytopathology: An international, multi-institutional study. Cancer Cytopathol. 127:306–315. 2019.PubMed/NCBI View Article : Google Scholar

12 

Viswanathan K, Sung S, Scognamiglio T, Yang GCH, Siddiqui MT and Rao RA: The role of the milan system for reporting salivary gland cytopathology: A 5-year institutional experience. Cancer Cytopathol. 126:541–551. 2018.PubMed/NCBI View Article : Google Scholar

13 

Faquin WC and Rossi ED (eds): The Milan System for Reporting Salivary Gland Cytopathology. Springer International Publishing AG (2nd ed.), Switzerland, 2023. https://link.springer.com/book/10.1007/978-3-031-26662-1.

14 

Maleki Z, Allison DB, Butcher M, Kawamoto S, Eisele DW and Pantanowitz L: Application of the milan system for reporting salivary gland cytopathology to cystic salivary gland lesions. Cancer Cytopathol. 129:214–225. 2021.PubMed/NCBI View Article : Google Scholar

15 

Pantanowitz L, Thompson LDR and Rossi ED: Diagnostic approach to fine needle aspirations of cystic lesions of the salivary gland. Head Neck Pathol. 12:548–561. 2018.PubMed/NCBI View Article : Google Scholar

16 

Choudhury S: Benign lymphoepithelial cyst of parotid gland: A pathologist's perspective. J Cytol. 40:217–219. 2023.PubMed/NCBI View Article : Google Scholar

17 

Gomez M, Yu W and Sneige N: The milan system for reporting salivary gland cytopathology: The experience of a tertiary cancer center with emphasis on non-mucinous cysts and improving diagnostic results. J Am Soc Cytopathol. 13:59–66. 2024.PubMed/NCBI View Article : Google Scholar

18 

Allison DB, McCuiston AM, Kawamoto S, Eisele DW, Bishop JA and Maleki Z: Cystic major salivary gland lesions: Utilizing fine needle aspiration to optimize the clinical management of a broad and diverse differential diagnosis. Diagn Cytopathol. 45:800–807. 2017.PubMed/NCBI View Article : Google Scholar

19 

Sun T, Faquin WC and Torous VF: Crystalloids in FNA specimens of salivary gland lesions: A retrospective study in a single large institute. Cancer Cytopathol. 129:432–438. 2021.PubMed/NCBI View Article : Google Scholar

20 

Pantanowitz L, Goulart RA and Cao QJ: Salivary gland crystalloids. Diagn Cytopathol. 34:749–750. 2006.PubMed/NCBI View Article : Google Scholar

21 

Okano K, Arimoto T, Ishida M, Sandoh K, Fujisawa T, Iwai H and Tsuta K: Collagenous crystalloids in pleomorphic adenoma of the parotid gland. Diagn Cytopathol. 47:612–613. 2019.PubMed/NCBI View Article : Google Scholar

22 

Hubbard EW, Winkler M and Davis T: Amylase crystalloids in nonneoplastic salivary gland: A distinct finding. Diagn Cytopathol. 43:835–837. 2015.PubMed/NCBI View Article : Google Scholar

23 

López-Ríos F, Díaz-Bustamante T, Serrano-Egea A, Jiménez J and de Agustín P: Amylase crystalloids in salivary gland lesions: Report of a case with a review of the literature. Diagn Cytopathol. 25:59–62. 2001.PubMed/NCBI View Article : Google Scholar

24 

López-Ríos F, Ballestín C, Martínez-González MA, Serrano R and de Agustín PP: Lymphoepithelial cyst with crystalloid formation. Cytologic features of two cases. Acta Cytol. 43:277–280. 1999.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ishida M, Kataoka I, Tomiuka M, Okanishi H, Ariga K, Uragami M, Deguchi C, Ono S, Takeda R, Hirose Y, Hirose Y, et al: Cytological features of a lymphoepithelial cyst of the salivary gland with application of the second edition of Milan System for Reporting Salivary Gland Cytopathology . Mol Clin Oncol 21: 52, 2024.
APA
Ishida, M., Kataoka, I., Tomiuka, M., Okanishi, H., Ariga, K., Uragami, M. ... Hirose, Y. (2024). Cytological features of a lymphoepithelial cyst of the salivary gland with application of the second edition of Milan System for Reporting Salivary Gland Cytopathology . Molecular and Clinical Oncology, 21, 52. https://doi.org/10.3892/mco.2024.2750
MLA
Ishida, M., Kataoka, I., Tomiuka, M., Okanishi, H., Ariga, K., Uragami, M., Deguchi, C., Ono, S., Takeda, R., Hirose, Y."Cytological features of a lymphoepithelial cyst of the salivary gland with application of the second edition of Milan System for Reporting Salivary Gland Cytopathology ". Molecular and Clinical Oncology 21.2 (2024): 52.
Chicago
Ishida, M., Kataoka, I., Tomiuka, M., Okanishi, H., Ariga, K., Uragami, M., Deguchi, C., Ono, S., Takeda, R., Hirose, Y."Cytological features of a lymphoepithelial cyst of the salivary gland with application of the second edition of Milan System for Reporting Salivary Gland Cytopathology ". Molecular and Clinical Oncology 21, no. 2 (2024): 52. https://doi.org/10.3892/mco.2024.2750
Copy and paste a formatted citation
x
Spandidos Publications style
Ishida M, Kataoka I, Tomiuka M, Okanishi H, Ariga K, Uragami M, Deguchi C, Ono S, Takeda R, Hirose Y, Hirose Y, et al: Cytological features of a lymphoepithelial cyst of the salivary gland with application of the second edition of Milan System for Reporting Salivary Gland Cytopathology . Mol Clin Oncol 21: 52, 2024.
APA
Ishida, M., Kataoka, I., Tomiuka, M., Okanishi, H., Ariga, K., Uragami, M. ... Hirose, Y. (2024). Cytological features of a lymphoepithelial cyst of the salivary gland with application of the second edition of Milan System for Reporting Salivary Gland Cytopathology . Molecular and Clinical Oncology, 21, 52. https://doi.org/10.3892/mco.2024.2750
MLA
Ishida, M., Kataoka, I., Tomiuka, M., Okanishi, H., Ariga, K., Uragami, M., Deguchi, C., Ono, S., Takeda, R., Hirose, Y."Cytological features of a lymphoepithelial cyst of the salivary gland with application of the second edition of Milan System for Reporting Salivary Gland Cytopathology ". Molecular and Clinical Oncology 21.2 (2024): 52.
Chicago
Ishida, M., Kataoka, I., Tomiuka, M., Okanishi, H., Ariga, K., Uragami, M., Deguchi, C., Ono, S., Takeda, R., Hirose, Y."Cytological features of a lymphoepithelial cyst of the salivary gland with application of the second edition of Milan System for Reporting Salivary Gland Cytopathology ". Molecular and Clinical Oncology 21, no. 2 (2024): 52. https://doi.org/10.3892/mco.2024.2750
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team