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The updated relationship between the cleft‑lip and palate transmembrane protein‑1‑like rs401681 and lung cancer risk: A systematic review and meta‑analysis

  • Authors:
    • Zemin Fang
    • Gaofeng Zhao
    • Yuebin Wang
    • Fengke Li
    • Zhidan Ding
  • View Affiliations / Copyright

    Affiliations: Department of Lung Transplant, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China
    Copyright: © Fang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 70
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    Published online on: July 31, 2024
       https://doi.org/10.3892/mco.2024.2768
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Abstract

Currently, the role of cleft‑lip and palate transmembrane protein‑1‑like (CLPTM1L) rs401681 in various tumor types, particularly lung cancer, has garnered significant attention. However, the findings across studies have shown discrepancies. The aim of the present meta‑analysis was to provide a more nuanced understanding of the involvement of CLPTM1L rs401681 in lung cancer development. Several electronic databases were systematically searched, including PubMed, Cochrane Library, Embase, Medline, Wanfang, Google Scholar and Chinese National Knowledge Infrastructure. Odds ratios (ORs) and 95% confidence intervals (CIs) were synthesized using random‑effects models. Heterogeneity of included studies was assessed using the I2 statistic and Q test. Sensitivity analysis was conducted to evaluate the stability of overall estimates. Moreover, Egger's test was utilized to detect potential publication bias. The collective ORs indicated a significant association between the CLPTM1L rs401681 polymorphism and susceptibility to lung cancer across various genetic comparisons. These encompass allele T vs. allele C (OR=0.93, 95% CI=0.88‑0.99, P<0.001), TT + CT vs. CC (OR=0.91, 95% CI=0.87‑0.96, P<0.001), TT vs. CC + CT (OR=0.88, 95% CI=0.80‑0.96, P<0.001), TT vs. CC (OR=0.84, 95% CI=0.75‑0.94, P<0.001) and CT vs. CC (OR=0.84, 95% CI=0.75‑0.94, P<0.001). Examination through statistical Q test and I2 statistic revealed pronounced heterogeneity across four genetic comparisons (allele T vs. allele C, TT + CT vs. CC, TT vs. CC and CT vs. CC). Ethnical distinctions emerged as the primary, if not exclusive, sources of the significant heterogeneity. Upon stratification by ethnicity, a notable reduction in heterogeneity was discernible within the Caucasian demographic. However, heterogeneity persisted within the Asian population. Furthermore, lung cancer risks were statistically significantly decreased for individuals possessing allele T through all genetic comparisons within Caucasians; whereas among Asians, significant reduction was observed solely in the TT vs. CC comparison. The present meta‑analysis uncovers a significant association between the CLPTM1L rs401681 polymorphism and altered susceptibility to lung cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Fang Z, Zhao G, Wang Y, Li F and Ding Z: The updated relationship between the cleft‑lip and palate transmembrane protein‑1‑like rs401681 and lung cancer risk: A systematic review and meta‑analysis. Mol Clin Oncol 21: 70, 2024.
APA
Fang, Z., Zhao, G., Wang, Y., Li, F., & Ding, Z. (2024). The updated relationship between the cleft‑lip and palate transmembrane protein‑1‑like rs401681 and lung cancer risk: A systematic review and meta‑analysis. Molecular and Clinical Oncology, 21, 70. https://doi.org/10.3892/mco.2024.2768
MLA
Fang, Z., Zhao, G., Wang, Y., Li, F., Ding, Z."The updated relationship between the cleft‑lip and palate transmembrane protein‑1‑like rs401681 and lung cancer risk: A systematic review and meta‑analysis". Molecular and Clinical Oncology 21.4 (2024): 70.
Chicago
Fang, Z., Zhao, G., Wang, Y., Li, F., Ding, Z."The updated relationship between the cleft‑lip and palate transmembrane protein‑1‑like rs401681 and lung cancer risk: A systematic review and meta‑analysis". Molecular and Clinical Oncology 21, no. 4 (2024): 70. https://doi.org/10.3892/mco.2024.2768
Copy and paste a formatted citation
x
Spandidos Publications style
Fang Z, Zhao G, Wang Y, Li F and Ding Z: The updated relationship between the cleft‑lip and palate transmembrane protein‑1‑like rs401681 and lung cancer risk: A systematic review and meta‑analysis. Mol Clin Oncol 21: 70, 2024.
APA
Fang, Z., Zhao, G., Wang, Y., Li, F., & Ding, Z. (2024). The updated relationship between the cleft‑lip and palate transmembrane protein‑1‑like rs401681 and lung cancer risk: A systematic review and meta‑analysis. Molecular and Clinical Oncology, 21, 70. https://doi.org/10.3892/mco.2024.2768
MLA
Fang, Z., Zhao, G., Wang, Y., Li, F., Ding, Z."The updated relationship between the cleft‑lip and palate transmembrane protein‑1‑like rs401681 and lung cancer risk: A systematic review and meta‑analysis". Molecular and Clinical Oncology 21.4 (2024): 70.
Chicago
Fang, Z., Zhao, G., Wang, Y., Li, F., Ding, Z."The updated relationship between the cleft‑lip and palate transmembrane protein‑1‑like rs401681 and lung cancer risk: A systematic review and meta‑analysis". Molecular and Clinical Oncology 21, no. 4 (2024): 70. https://doi.org/10.3892/mco.2024.2768
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