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Effect of anamorelin treatment duration on survival of patients with cancer cachexia: A retrospective study

  • Authors:
    • Miyu Sasaya
    • Daisuke Takei
    • Tomoya Abe
    • Makoto Hiraide
    • Kazuhiro Torigoe
    • Toshiaki Nakayama
    • Masanobu Otsuka
    • Motohiko Sano
  • View Affiliations / Copyright

    Affiliations: Laboratory of Clinical Pharmacy Assessment, Hoshi University, Tokyo 142‑8501, Japan, Pharmaceutical Department, Saitama Cancer Center, Ina, Saitama 362‑0806, Japan, Department of Clinical Assessment, Tokyo University of Pharmacy and Life Sciences, Tokyo 192‑0392, Japan, Shonan University of Medical Sciences, Yokohama, Kanagawa 244‑0806, Japan
    Copyright: © Sasaya et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 63
    |
    Published online on: May 15, 2025
       https://doi.org/10.3892/mco.2025.2858
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Abstract

Real‑world data on the effectiveness of anamorelin in managing cancer cachexia remains limited, particularly as its availability is currently restricted to Japan. In the present study, anamorelin use in cancer cachexia management was retrospectively evaluated, focusing on patient characteristics and survival after both short‑ and long‑term use. Patients prescribed anamorelin between August 2021 and January 2024 at the Saitama Cancer Center (Ina, Japan) were included. Medical records were reviewed to collect baseline characteristics at anamorelin treatment initiation. The patients were divided into two groups: short‑ and long‑treatment groups (STT and LTT, respectively). Overall, 60 and 69 patients were included in the STT and LTT groups, respectively. Significant intergroup differences were found in age (P=0.021), gastric cancer incidence rate (P=0.013), albumin level of <3.5 g/dl (P=0.044) and Eastern Cooperative Oncology Group performance status score (P=0.008). The longest median time from diagnosis to anamorelin treatment initiation was observed for colorectal cancer, while the longest median anamorelin treatment duration was observed for lung cancer. The median survival durations during anamorelin treatment were 49 and 142 days in the STT and LTT groups, respectively (P<0.001). The corresponding median survival durations after anamorelin treatment termination in the STT and LTT groups were 38 and 34 days (P=0.554), respectively. Anamorelin treatment duration influenced patient survival, with post‑discontinuation survival being ~1 month, regardless of treatment length.
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Copy and paste a formatted citation
Spandidos Publications style
Sasaya M, Takei D, Abe T, Hiraide M, Torigoe K, Nakayama T, Otsuka M and Sano M: Effect of anamorelin treatment duration on survival of patients with cancer cachexia: A retrospective study. Mol Clin Oncol 23: 63, 2025.
APA
Sasaya, M., Takei, D., Abe, T., Hiraide, M., Torigoe, K., Nakayama, T. ... Sano, M. (2025). Effect of anamorelin treatment duration on survival of patients with cancer cachexia: A retrospective study. Molecular and Clinical Oncology, 23, 63. https://doi.org/10.3892/mco.2025.2858
MLA
Sasaya, M., Takei, D., Abe, T., Hiraide, M., Torigoe, K., Nakayama, T., Otsuka, M., Sano, M."Effect of anamorelin treatment duration on survival of patients with cancer cachexia: A retrospective study". Molecular and Clinical Oncology 23.1 (2025): 63.
Chicago
Sasaya, M., Takei, D., Abe, T., Hiraide, M., Torigoe, K., Nakayama, T., Otsuka, M., Sano, M."Effect of anamorelin treatment duration on survival of patients with cancer cachexia: A retrospective study". Molecular and Clinical Oncology 23, no. 1 (2025): 63. https://doi.org/10.3892/mco.2025.2858
Copy and paste a formatted citation
x
Spandidos Publications style
Sasaya M, Takei D, Abe T, Hiraide M, Torigoe K, Nakayama T, Otsuka M and Sano M: Effect of anamorelin treatment duration on survival of patients with cancer cachexia: A retrospective study. Mol Clin Oncol 23: 63, 2025.
APA
Sasaya, M., Takei, D., Abe, T., Hiraide, M., Torigoe, K., Nakayama, T. ... Sano, M. (2025). Effect of anamorelin treatment duration on survival of patients with cancer cachexia: A retrospective study. Molecular and Clinical Oncology, 23, 63. https://doi.org/10.3892/mco.2025.2858
MLA
Sasaya, M., Takei, D., Abe, T., Hiraide, M., Torigoe, K., Nakayama, T., Otsuka, M., Sano, M."Effect of anamorelin treatment duration on survival of patients with cancer cachexia: A retrospective study". Molecular and Clinical Oncology 23.1 (2025): 63.
Chicago
Sasaya, M., Takei, D., Abe, T., Hiraide, M., Torigoe, K., Nakayama, T., Otsuka, M., Sano, M."Effect of anamorelin treatment duration on survival of patients with cancer cachexia: A retrospective study". Molecular and Clinical Oncology 23, no. 1 (2025): 63. https://doi.org/10.3892/mco.2025.2858
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