Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
July-2025 Volume 23 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2025 Volume 23 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Disparities in long‑term outcomes between benign and malignant diseases after Hartmann's procedure: A retrospective observational study 

  • Authors:
    • Ken Imaizumi
    • Hiroyuki Kasajima
    • Aya Sato
    • Kentaro Sato
    • Keiichiro Ito
    • Takumu Fukasawa
    • Kentaro Ichimura
    • Tadashi Odagiri
    • Daisuke Yamana
    • Yosuke Tsuruga
    • Minoru Umehara
    • Michihiro Kurushima
    • Kazuaki Nakanishi
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Hakodate Municipal Hospital, Hakodate, Hokkaido 041‑8680, Japan
    Copyright: © Imaizumi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 64
    |
    Published online on: May 15, 2025
       https://doi.org/10.3892/mco.2025.2859
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The long‑term course following Hartmann's procedure (HP) has not yet been clarified. The present study aimed to compare the achievement of stoma reversal between benign and malignant diseases, and explore post‑reversal long‑term outcomes. Patients who underwent HP between June 2005 and December 2021 at a single center were retrospectively evaluated. The primary endpoint was the difference in stoma‑reversal rate between benign and malignant diseases. The secondary endpoints were identification of the predictive factors for stoma reversal and comparison of stoma‑free survival and anorectal functions after reversal between patients with benign and malignant diseases. Among 261 patients, the benign and malignant disease groups comprised 102 and 159 patients, respectively. Malignant disease (P=0.044), low Charlson's comorbidity index (P<0.001), urgent HP (performed as a lifesaving procedure; P=0.003) and home discharge (P<0.001) were significantly associated with stoma reversal in the multivariate analysis. Furthermore, cumulative stoma‑reversal rate was significantly lower in the malignant disease than in the benign disease group (P<0.001). In 44 patients who underwent stoma reversal, the rate of stoma‑free survival in the malignant disease group was significantly reduced compared with that in the benign disease group at 10 years after reversal (P=0.004). No significant between‑group differences were observed regarding anorectal function (n=24). In conclusion, the achievement of stoma reversal and the stoma‑free survival rate after reversal may be lower in patients with malignant disease than in those with benign disease; however, anorectal function after reversal may not be markedly different. 
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Albarran SA, Simoens Ch, Van De Winkel N, da Costa PM and Thill V: Restoration of digestive continuity after Hartmann's procedure: ASA score is a predictive factor for risk of postoperative complications. Acta Chir Belg. 109:714–719. 2009.PubMed/NCBI View Article : Google Scholar

2 

Moro-Valdezate D, Royo-Aznar A, Martín-Arévalo J, Pla-Martí V, García-Botello S, León-Espinoza C, Fernández-Moreno MC, Espín-Basany E and Espí-Macías A: Outcomes of Hartmann's procedure and subsequent intestinal restoration. Which patients are most likely to undergo reversal? Am J Surg. 218:918–927. 2019.PubMed/NCBI View Article : Google Scholar

3 

Christou N, Rivaille T, Maulat C, Taibi A, Fredon F, Bouvier S, Fabre A, Derbal S, Durand-Fontanier S, Valleix D, et al: Identification of risk factors for morbidity and mortality after Hartmann's reversal surgery-a retrospective study from two French centers. Sci Rep. 10(3643)2020.PubMed/NCBI View Article : Google Scholar

4 

Edomskis PP, Hoek VT, Stark PW, Lambrichts DPV, Draaisma WA, Consten ECJ, Bemelman WA and Lange JF: LADIES trial collaborators. Hartmann's procedure versus sigmoidectomy with primary anastomosis for perforated diverticulitis with purulent or fecal peritonitis: Three-year follow-up of a randomised controlled trial. Int J Surg. 98(106221)2022.PubMed/NCBI View Article : Google Scholar

5 

Royo-Aznar A, Moro-Valdezate D, Martín-Arévalo J, Pla-Martí V, García-Botello S, Espín-Basany E and Espí-Macías A: Reversal of Hartmann's procedure: A single-centre experience of 533 consecutive cases. Colorectal Dis. 20:631–638. 2018.PubMed/NCBI View Article : Google Scholar

6 

Katsura M, Fukuma S, Chida K, Saegusa Y, Kanda S, Kawasaki K, Tsuzuki Y and Ie M: Which factors influence the decision to perform Hartmann's reversal in various causative disease situations? A retrospective cohort study between 2006 and 2021. Colorectal Dis. 25:305–314. 2023.PubMed/NCBI View Article : Google Scholar

7 

Banerjee S, Leather AJ, Rennie JA, Samano N, Gonzalez JG and Papagrigoriadis S: Feasibility and morbidity of reversal of Hartmann's. Colorectal Dis. 7:454–459. 2005.PubMed/NCBI View Article : Google Scholar

8 

Toro A, Ardiri A, Mannino M, Politi A, Di Stefano A, Aftab Z, Abdelaal A, Arcerito MC, Cavallaro A, Cavallaro M, et al: Laparoscopic reversal of Hartmann's procedure: State of the art 20 years after the first reported case. Gastroent Res Pract. 2014(530140)2014.PubMed/NCBI View Article : Google Scholar

9 

Caille C, Collard M, Moszkowicz D, Prost À la Denise J, Maggiori L and Panis Y: Reversal of Hartmann's procedure in patients following failed colorectal or coloanal anastomosis: An analysis of 45 consecutive cases. Colorectal Dis. 22:203–211. 2020.PubMed/NCBI View Article : Google Scholar

10 

Van Hoof S, Sels T, Patteet E, Hendrickx T, Van den Broeck S, Hubens G and Komen N: Functional outcome after Hartmann's reversal surgery using LARS, COREFO & QoL scores. Am J Surg. 225:341–346. 2023.PubMed/NCBI View Article : Google Scholar

11 

Charlson ME, Pompei P, Ales KL and MacKenzie CR: A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 40:373–383. 1987.PubMed/NCBI View Article : Google Scholar

12 

Dindo D, Demartines N and Clavien PA: Classification of surgical complications: A new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 240:205–213. 2004.PubMed/NCBI View Article : Google Scholar

13 

Kanda Y: Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 48:452–458. 2013.PubMed/NCBI View Article : Google Scholar

14 

Oh HK, Han EC, Ha HK, Choe EK, Moon SH, Ryoo SB, Jeong SY and Park KJ: Surgical management of colonic diverticular disease: Discrepancy between right- and left-sided diseases. World J Gastroenterol. 20:10115–10120. 2014.PubMed/NCBI View Article : Google Scholar

15 

Trépanier JS, Arroyave MC, Bravo R, Jiménez-Toscano M, DeLacy FB, Fernandez-Hevia M and Lacy AM: Transanal Hartmann's colostomy reversal assisted by laparoscopy: Outcomes of the first 10 patients. Surg Endosc. 31:4981–4987. 2017.PubMed/NCBI View Article : Google Scholar

16 

Giuliani G, Formisano G, Milone M, Salaj A, Salvischiani L and Bianchi PP: Full robotic Hartmann's reversal: Technical aspects and preliminary experience. Colorectal Dis. 22:1734–1740. 2020.PubMed/NCBI View Article : Google Scholar

17 

van Loon YT, Clermonts SHEM, Wasowicz DK and Zimmerman DDE: Reversal of left-sided colostomy utilizing single-port laparoscopy: Single-center consolidation of a new technique. Surg Endosc. 34:332–338. 2020.PubMed/NCBI View Article : Google Scholar

18 

Sato K, Kasajima H, Yamana D, Imaizumi K and Nakanishi K: Technique of the Single-port laparoscopic Hartmann's reversal via the colostomy Site-A video vignette. Colorectal Dis. 25:1050–1051. 2023.PubMed/NCBI View Article : Google Scholar

19 

Siddiqui MR, Sajid MS and Baig MK: Open vs laparoscopic approach for reversal of Hartmann's procedure: A systematic review. Colorectal Dis. 12:733–741. 2010.PubMed/NCBI View Article : Google Scholar

20 

van de Wall BJ, Draaisma WA, Schouten ES, Broeders IA and Consten EC: Conventional and laparoscopic reversal of the Hartmann procedure: A review of literature. J Gastrointest Surg. 14:743–752. 2010.PubMed/NCBI View Article : Google Scholar

21 

Ng DC, Guarino S, Yau SL, Fok BK, Cheung HY, Li MK and Tang CN: Laparoscopic reversal of Hartmann's procedure: Safety and feasibility. Gastroenterol Rep (Oxf). 1:149–152. 2013.PubMed/NCBI View Article : Google Scholar

22 

Horesh N, Lessing Y, Rudnicki Y, Kent I, Kammar H, Ben-Yaacov A, Dreznik Y, Avital S, Mavor E, Wasserberg N, et al: Comparison between laparoscopic and open Hartmann's reversal: Results of a Decade-long multicenter retrospective study. Surg Endosc. 32:4780–4787. 2018.PubMed/NCBI View Article : Google Scholar

23 

Pei KY, Davis KA and Zhang Y: Assessing trends in laparoscopic colostomy reversal and evaluating outcomes when compared to open procedures. Surg Endosc. 32:695–701. 2018.PubMed/NCBI View Article : Google Scholar

24 

Chen HS and Sheen-Chen SM: Obstruction and perforation in colorectal adenocarcinoma: An analysis of prognosis and current trends. Surgery. 127:370–376. 2000.PubMed/NCBI View Article : Google Scholar

25 

Ogawa K, Miyamoto Y, Harada K, Eto K, Sawayama H and Iwagam S: Evaluation of clinical outcomes with propensity-score matching for colorectal cancer presenting as an oncologic emergency. Ann Gastroenterol Surg. 6:523–530. 2022.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Imaizumi K, Kasajima H, Sato A, Sato K, Ito K, Fukasawa T, Ichimura K, Odagiri T, Yamana D, Tsuruga Y, Tsuruga Y, et al: Disparities in long‑term outcomes between benign and malignant diseases after Hartmann's procedure: A retrospective observational study&nbsp;. Mol Clin Oncol 23: 64, 2025.
APA
Imaizumi, K., Kasajima, H., Sato, A., Sato, K., Ito, K., Fukasawa, T. ... Nakanishi, K. (2025). Disparities in long‑term outcomes between benign and malignant diseases after Hartmann's procedure: A retrospective observational study&nbsp;. Molecular and Clinical Oncology, 23, 64. https://doi.org/10.3892/mco.2025.2859
MLA
Imaizumi, K., Kasajima, H., Sato, A., Sato, K., Ito, K., Fukasawa, T., Ichimura, K., Odagiri, T., Yamana, D., Tsuruga, Y., Umehara, M., Kurushima, M., Nakanishi, K."Disparities in long‑term outcomes between benign and malignant diseases after Hartmann's procedure: A retrospective observational study&nbsp;". Molecular and Clinical Oncology 23.1 (2025): 64.
Chicago
Imaizumi, K., Kasajima, H., Sato, A., Sato, K., Ito, K., Fukasawa, T., Ichimura, K., Odagiri, T., Yamana, D., Tsuruga, Y., Umehara, M., Kurushima, M., Nakanishi, K."Disparities in long‑term outcomes between benign and malignant diseases after Hartmann's procedure: A retrospective observational study&nbsp;". Molecular and Clinical Oncology 23, no. 1 (2025): 64. https://doi.org/10.3892/mco.2025.2859
Copy and paste a formatted citation
x
Spandidos Publications style
Imaizumi K, Kasajima H, Sato A, Sato K, Ito K, Fukasawa T, Ichimura K, Odagiri T, Yamana D, Tsuruga Y, Tsuruga Y, et al: Disparities in long‑term outcomes between benign and malignant diseases after Hartmann's procedure: A retrospective observational study&nbsp;. Mol Clin Oncol 23: 64, 2025.
APA
Imaizumi, K., Kasajima, H., Sato, A., Sato, K., Ito, K., Fukasawa, T. ... Nakanishi, K. (2025). Disparities in long‑term outcomes between benign and malignant diseases after Hartmann's procedure: A retrospective observational study&nbsp;. Molecular and Clinical Oncology, 23, 64. https://doi.org/10.3892/mco.2025.2859
MLA
Imaizumi, K., Kasajima, H., Sato, A., Sato, K., Ito, K., Fukasawa, T., Ichimura, K., Odagiri, T., Yamana, D., Tsuruga, Y., Umehara, M., Kurushima, M., Nakanishi, K."Disparities in long‑term outcomes between benign and malignant diseases after Hartmann's procedure: A retrospective observational study&nbsp;". Molecular and Clinical Oncology 23.1 (2025): 64.
Chicago
Imaizumi, K., Kasajima, H., Sato, A., Sato, K., Ito, K., Fukasawa, T., Ichimura, K., Odagiri, T., Yamana, D., Tsuruga, Y., Umehara, M., Kurushima, M., Nakanishi, K."Disparities in long‑term outcomes between benign and malignant diseases after Hartmann's procedure: A retrospective observational study&nbsp;". Molecular and Clinical Oncology 23, no. 1 (2025): 64. https://doi.org/10.3892/mco.2025.2859
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team