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AEG‑1 expression analysis in epithelial ovarian carcinoma: Uncovering distinctions between high‑grade and low‑grade serous carcinoma

  • Authors:
    • Budi Irawan
    • Brahmana Askandar Tjokroprawiro
    • Wita Saraswati
    • Indra Yuliati
    • Pungky Mulawardhana
    • Budi Utomo
    • Grace Ariani
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, East Java 60286, Indonesia, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga, Airlangga University Academic Hospital, Surabaya, East Java 60115, Indonesia, Department of Public Health Sciences‑Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java 60131, Indonesia, Department of Anatomical Pathology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, East Java 60286, Indonesia
    Copyright: © Irawan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 70
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    Published online on: June 4, 2025
       https://doi.org/10.3892/mco.2025.2865
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Abstract

Epithelial ovarian carcinoma (EOC) is the most common form of ovarian cancer and is associated with a poor prognosis. Astrocyte Elevated Gene‑1 (AEG‑1) is an oncogene implicated in cancer cell growth and progression. The present study examined AEG‑1 expression in EOC, specifically comparing high‑grade serous ovarian carcinoma (HGSOC) and low‑grade serous ovarian carcinoma (LGSOC). The present retrospective analytical study employed a cross‑sectional design and included women diagnosed with HGSOC or LGSOC between January 2021 and December 2023. Extracted data included demographic, laboratory and clinicopathological characteristics. In addition to comparing AEG‑1 expression in HGSOC and LGSOC, associations between these histological subtypes and the extracted variables, as well as associations between AEG‑1 expression and these variables, were assessed. Of the 74 patients initially identified, 24 were excluded, resulting in a final sample of 50 patients 23 with LGSOC and 27 with HGSOC. A statistically significant association was found between residual disease and cancer histopathology [odds ratio: 7.219; 95% confidence interval (CI): 1.399‑37.252; P=0.024), whereas no significant associations were observed with other variables. AEG‑1 expression was significantly higher in HGSOC compared with LGSOC (relative risk: 3.228; 95% CI: 1.188‑8.776; P=0.012), with high AEG‑1 expression observed more frequently in HGSOC (65.7%) than in LGSOC (34.3%). In conclusion, AEG‑1 expression was significantly elevated in HGSOC compared with LGSOC, suggesting a potential role for AEG‑1 in the progression of HGSOC.
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Copy and paste a formatted citation
Spandidos Publications style
Irawan B, Tjokroprawiro B, Saraswati W, Yuliati I, Mulawardhana P, Utomo B and Ariani G: AEG‑1 expression analysis in epithelial ovarian carcinoma: Uncovering distinctions between high‑grade and low‑grade serous carcinoma. Mol Clin Oncol 23: 70, 2025.
APA
Irawan, B., Tjokroprawiro, B., Saraswati, W., Yuliati, I., Mulawardhana, P., Utomo, B., & Ariani, G. (2025). AEG‑1 expression analysis in epithelial ovarian carcinoma: Uncovering distinctions between high‑grade and low‑grade serous carcinoma. Molecular and Clinical Oncology, 23, 70. https://doi.org/10.3892/mco.2025.2865
MLA
Irawan, B., Tjokroprawiro, B., Saraswati, W., Yuliati, I., Mulawardhana, P., Utomo, B., Ariani, G."AEG‑1 expression analysis in epithelial ovarian carcinoma: Uncovering distinctions between high‑grade and low‑grade serous carcinoma". Molecular and Clinical Oncology 23.2 (2025): 70.
Chicago
Irawan, B., Tjokroprawiro, B., Saraswati, W., Yuliati, I., Mulawardhana, P., Utomo, B., Ariani, G."AEG‑1 expression analysis in epithelial ovarian carcinoma: Uncovering distinctions between high‑grade and low‑grade serous carcinoma". Molecular and Clinical Oncology 23, no. 2 (2025): 70. https://doi.org/10.3892/mco.2025.2865
Copy and paste a formatted citation
x
Spandidos Publications style
Irawan B, Tjokroprawiro B, Saraswati W, Yuliati I, Mulawardhana P, Utomo B and Ariani G: AEG‑1 expression analysis in epithelial ovarian carcinoma: Uncovering distinctions between high‑grade and low‑grade serous carcinoma. Mol Clin Oncol 23: 70, 2025.
APA
Irawan, B., Tjokroprawiro, B., Saraswati, W., Yuliati, I., Mulawardhana, P., Utomo, B., & Ariani, G. (2025). AEG‑1 expression analysis in epithelial ovarian carcinoma: Uncovering distinctions between high‑grade and low‑grade serous carcinoma. Molecular and Clinical Oncology, 23, 70. https://doi.org/10.3892/mco.2025.2865
MLA
Irawan, B., Tjokroprawiro, B., Saraswati, W., Yuliati, I., Mulawardhana, P., Utomo, B., Ariani, G."AEG‑1 expression analysis in epithelial ovarian carcinoma: Uncovering distinctions between high‑grade and low‑grade serous carcinoma". Molecular and Clinical Oncology 23.2 (2025): 70.
Chicago
Irawan, B., Tjokroprawiro, B., Saraswati, W., Yuliati, I., Mulawardhana, P., Utomo, B., Ariani, G."AEG‑1 expression analysis in epithelial ovarian carcinoma: Uncovering distinctions between high‑grade and low‑grade serous carcinoma". Molecular and Clinical Oncology 23, no. 2 (2025): 70. https://doi.org/10.3892/mco.2025.2865
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