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Article Open Access

Oncological outcome of surgical resection for anaplastic carcinoma of the pancreas

  • Authors:
    • Itaru Sonoda
    • Takanori Konishi
    • Shigetsugu Takano
    • Tsukasa Takayashiki
    • Daisuke Suzuki
    • Nozomu Sakai
    • Isamu Hosokawa
    • Takashi Mishima
    • Hitoe Nishino
    • Kensuke Suzuki
    • Shinichiro Nakada
    • Masayuki Ohtsuka
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Chiba 260‑8670, Japan
    Copyright: © Sonoda et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 107
    |
    Published online on: October 6, 2025
       https://doi.org/10.3892/mco.2025.2902
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Abstract

Anaplastic carcinoma of the pancreas (ACP) is a rare disease with rapid growth. Therefore, the significance of surgery for ACP remains unknown. The present study aimed to elucidate the oncological outcome following surgical resection for ACP and investigated pathological features associated with prognosis. In the present study, 12 patients who underwent surgical resection for ACP at Chiba University Hospital (Chiba, Japan) were retrospectively analyzed. Among the 12 patients, 7 had anaplastic undifferentiated carcinoma, 1 had sarcomatoid undifferentiated carcinoma, 2 had carcinosarcoma and 2 had undifferentiated carcinoma with osteoclast‑like giant cells (OCGC). A total of 7 cases exhibited early recurrence within 6 months postoperatively, and the median overall survival (OS) time of the patients with curative resection was 15.0 months, which was shorter than that of patients with pancreatic ductal adenocarcinoma. The median OS time of patients with pT3 was significantly shorter than that of those with pT1 or pT2 (2.2 vs. 24.5 months; P<0.01). pT3 tumors frequently exhibited a high Ki‑67 proliferative index with tumor necrosis and intratumoral hemorrhage. These cases exhibited high serum inflammatory marker levels, including white blood cells, C‑reactive protein and neutrophil‑to‑lymphocyte ratio. On the other hand, 4 patients survived for ≥2 years without recurrence after surgery. These patients included 2 cases with undifferentiated carcinoma with OCGC and 2 pT1 cases with undifferentiated carcinoma who did not exhibit tumor necrosis or intratumoral hemorrhage. The present study demonstrated that a number of ACP cases exhibited early recurrence with poor survival, whereas limited cases experienced long‑term survival. The tumor subtype and pathological features, such as tumor diameter, tumor necrosis and intratumoral hemorrhage, may be associated with the postoperative prognosis of patients with ACP.
View Figures

Figure 1

Prognosis of patients with ACP after
surgery. (A) Disease-free survival rate after surgery in patients
with ACP. (B) Overall survival rate after surgery in patients with
ACP compared with that in patients with pancreatic ductal
adenocarcinoma. ACP, anaplastic carcinoma of the pancreas.

Figure 2

Clinicopathological factors associated
with OS of patients with ACP after surgery. (A) OS rate after
surgery stratified according to pathological T factor and lymph
node metastases in patients with ACP. (B) OS rate after surgery
stratified according to the CEA level, CA19-9 level, DUPAN-2 level
and Span-1 level in patients with ACP. ACP, anaplastic carcinoma of
the pancreas; CA19-9, carbohydrate antigen 19-9; CEA,
carcinoembryonic antigen; DUPAN-2, duke pancreatic monoclonal
antigen type 2; OS, overall survival; Span-1, s-pancreas-1
antigen.
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Copy and paste a formatted citation
Spandidos Publications style
Sonoda I, Konishi T, Takano S, Takayashiki T, Suzuki D, Sakai N, Hosokawa I, Mishima T, Nishino H, Suzuki K, Suzuki K, et al: Oncological outcome of surgical resection for anaplastic carcinoma of the pancreas. Mol Clin Oncol 23: 107, 2025.
APA
Sonoda, I., Konishi, T., Takano, S., Takayashiki, T., Suzuki, D., Sakai, N. ... Ohtsuka, M. (2025). Oncological outcome of surgical resection for anaplastic carcinoma of the pancreas. Molecular and Clinical Oncology, 23, 107. https://doi.org/10.3892/mco.2025.2902
MLA
Sonoda, I., Konishi, T., Takano, S., Takayashiki, T., Suzuki, D., Sakai, N., Hosokawa, I., Mishima, T., Nishino, H., Suzuki, K., Nakada, S., Ohtsuka, M."Oncological outcome of surgical resection for anaplastic carcinoma of the pancreas". Molecular and Clinical Oncology 23.6 (2025): 107.
Chicago
Sonoda, I., Konishi, T., Takano, S., Takayashiki, T., Suzuki, D., Sakai, N., Hosokawa, I., Mishima, T., Nishino, H., Suzuki, K., Nakada, S., Ohtsuka, M."Oncological outcome of surgical resection for anaplastic carcinoma of the pancreas". Molecular and Clinical Oncology 23, no. 6 (2025): 107. https://doi.org/10.3892/mco.2025.2902
Copy and paste a formatted citation
x
Spandidos Publications style
Sonoda I, Konishi T, Takano S, Takayashiki T, Suzuki D, Sakai N, Hosokawa I, Mishima T, Nishino H, Suzuki K, Suzuki K, et al: Oncological outcome of surgical resection for anaplastic carcinoma of the pancreas. Mol Clin Oncol 23: 107, 2025.
APA
Sonoda, I., Konishi, T., Takano, S., Takayashiki, T., Suzuki, D., Sakai, N. ... Ohtsuka, M. (2025). Oncological outcome of surgical resection for anaplastic carcinoma of the pancreas. Molecular and Clinical Oncology, 23, 107. https://doi.org/10.3892/mco.2025.2902
MLA
Sonoda, I., Konishi, T., Takano, S., Takayashiki, T., Suzuki, D., Sakai, N., Hosokawa, I., Mishima, T., Nishino, H., Suzuki, K., Nakada, S., Ohtsuka, M."Oncological outcome of surgical resection for anaplastic carcinoma of the pancreas". Molecular and Clinical Oncology 23.6 (2025): 107.
Chicago
Sonoda, I., Konishi, T., Takano, S., Takayashiki, T., Suzuki, D., Sakai, N., Hosokawa, I., Mishima, T., Nishino, H., Suzuki, K., Nakada, S., Ohtsuka, M."Oncological outcome of surgical resection for anaplastic carcinoma of the pancreas". Molecular and Clinical Oncology 23, no. 6 (2025): 107. https://doi.org/10.3892/mco.2025.2902
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