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D‑dimer as a more effective marker for detecting thrombosis in patients with ovarian clear cell carcinoma compared with high‑grade serous carcinoma

  • Authors:
    • Tsubasa Ito
    • Morikazu Miyamoto
    • Risa Tanabe
    • Soko Nishimura
    • Naohisa Kishimoto
    • Jin Suminokura
    • Taira Hada
    • Yuka Otsuka
    • Kento Kato
    • Hiroaki Soyama
    • Kohei Omatsu
    • Yoshinobu Hamada
    • Masashi Takano
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, National Defense Medical College Hospital, Tokorozawa, Saitama 359‑8513, Japan, Department of Clinical Oncology, National Defense Medical College Hospital, Tokorozawa, Saitama 359‑8513, Japan
    Copyright: © Ito et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 10
    |
    Published online on: November 26, 2025
       https://doi.org/10.3892/mco.2025.2919
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Abstract

The present retrospective cohort study aimed to examine the effectiveness of D‑dimer in detecting cancer‑associated thromboembolism (CAT) in clear cell carcinoma (CCC) compared with that in high‑grade serous carcinoma (HGSC) to develop an effective screening method. Patients diagnosed with CCC or HGSC who underwent primary surgery at National Defense Medical College Hospital (Tokorozawa, Japan) between January 2009 and December 2023 were included in the present study, and their clinical records were analyzed. Patients with a history of thrombosis and anticoagulation and those with acute infection at the initial visit were excluded. In the CCC and HGSC groups, 20 out of 79 patients (25.3%) and 15 out of 123 patients (12.2%) developed CAT, respectively, indicating that CAT was more common in patients with CCC (P=0.022). D‑dimer was a significantly better predictor in CCC [area under the curve (AUC), 0.92] than in HGSC (AUC, 0.75). Multivariate analysis demonstrated that the International Federation of Gynecology and Obstetrics (FIGO) stage was an independent risk factor for CAT (odds ratio, 3.28; 95% CI, 1.04‑10.3; P=0.042) in the CCC group. For CAT detection, combining D‑dimer with FIGO stage further improved the predictive accuracy in early‑stage CCC (AUC, 0.97). These results may be useful for CAT screening in clinical practice.
View Figures

Figure 1

Receiver operating characteristic
curves demonstrating the area under the curve of D-dimer for
predicting cancer-associated thrombosis in the (A) clear cell
carcinoma and (B) high-grade serous carcinoma groups. The yellow
line indicates the Youden Index as the optimal cutoff value.
View References

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Copy and paste a formatted citation
Spandidos Publications style
Ito T, Miyamoto M, Tanabe R, Nishimura S, Kishimoto N, Suminokura J, Hada T, Otsuka Y, Kato K, Soyama H, Soyama H, et al: D‑dimer as a more effective marker for detecting thrombosis in patients with ovarian clear cell carcinoma compared with high‑grade serous carcinoma. Mol Clin Oncol 24: 10, 2026.
APA
Ito, T., Miyamoto, M., Tanabe, R., Nishimura, S., Kishimoto, N., Suminokura, J. ... Takano, M. (2026). D‑dimer as a more effective marker for detecting thrombosis in patients with ovarian clear cell carcinoma compared with high‑grade serous carcinoma. Molecular and Clinical Oncology, 24, 10. https://doi.org/10.3892/mco.2025.2919
MLA
Ito, T., Miyamoto, M., Tanabe, R., Nishimura, S., Kishimoto, N., Suminokura, J., Hada, T., Otsuka, Y., Kato, K., Soyama, H., Omatsu, K., Hamada, Y., Takano, M."D‑dimer as a more effective marker for detecting thrombosis in patients with ovarian clear cell carcinoma compared with high‑grade serous carcinoma". Molecular and Clinical Oncology 24.1 (2026): 10.
Chicago
Ito, T., Miyamoto, M., Tanabe, R., Nishimura, S., Kishimoto, N., Suminokura, J., Hada, T., Otsuka, Y., Kato, K., Soyama, H., Omatsu, K., Hamada, Y., Takano, M."D‑dimer as a more effective marker for detecting thrombosis in patients with ovarian clear cell carcinoma compared with high‑grade serous carcinoma". Molecular and Clinical Oncology 24, no. 1 (2026): 10. https://doi.org/10.3892/mco.2025.2919
Copy and paste a formatted citation
x
Spandidos Publications style
Ito T, Miyamoto M, Tanabe R, Nishimura S, Kishimoto N, Suminokura J, Hada T, Otsuka Y, Kato K, Soyama H, Soyama H, et al: D‑dimer as a more effective marker for detecting thrombosis in patients with ovarian clear cell carcinoma compared with high‑grade serous carcinoma. Mol Clin Oncol 24: 10, 2026.
APA
Ito, T., Miyamoto, M., Tanabe, R., Nishimura, S., Kishimoto, N., Suminokura, J. ... Takano, M. (2026). D‑dimer as a more effective marker for detecting thrombosis in patients with ovarian clear cell carcinoma compared with high‑grade serous carcinoma. Molecular and Clinical Oncology, 24, 10. https://doi.org/10.3892/mco.2025.2919
MLA
Ito, T., Miyamoto, M., Tanabe, R., Nishimura, S., Kishimoto, N., Suminokura, J., Hada, T., Otsuka, Y., Kato, K., Soyama, H., Omatsu, K., Hamada, Y., Takano, M."D‑dimer as a more effective marker for detecting thrombosis in patients with ovarian clear cell carcinoma compared with high‑grade serous carcinoma". Molecular and Clinical Oncology 24.1 (2026): 10.
Chicago
Ito, T., Miyamoto, M., Tanabe, R., Nishimura, S., Kishimoto, N., Suminokura, J., Hada, T., Otsuka, Y., Kato, K., Soyama, H., Omatsu, K., Hamada, Y., Takano, M."D‑dimer as a more effective marker for detecting thrombosis in patients with ovarian clear cell carcinoma compared with high‑grade serous carcinoma". Molecular and Clinical Oncology 24, no. 1 (2026): 10. https://doi.org/10.3892/mco.2025.2919
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