|
1
|
Sung H, Ferlay J, Siegel RL, Laversanne M,
Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020:
GLOBOCAN estimates of incidence and mortality worldwide for 36
cancers in 185 countries. CA Cancer J Clin. 71:209–249.
2021.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Qiu H, Cao S and Xu R: Cancer incidence,
mortality, and burden in China: A time-trend analysis and
comparison with the United States and United Kingdom based on the
global epidemiological data released in 2020. Cancer Commun (Lond).
41:1037–1048. 2021.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Zhang M, Li N, Liang Y, Liu J, Zhou Y and
Liu C: Hyaluronic acid binding protein 1 overexpression is an
indicator for disease-free survival in cervical cancer. Int J Clin
Oncol. 22:347–352. 2017.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Yu H, Liu Q, Xin T, Xing L, Dong G, Jiang
Q, Lv Y, Song X, Teng C, Huang D, et al: Elevated expression of
hyaluronic acid binding protein 1 (HABP1)/P32/C1QBP is a novel
indicator for lymph node and peritoneal metastasis of epithelial
ovarian cancer patients. Tumour Biol. 34:3981–3987. 2013.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Zhao J, Liu T, Yu G and Wang J:
Overexpression of HABP1 correlated with clinicopathological
characteristics and unfavorable prognosis in endometrial cancer.
Tumour Biol. 36:1299–1306. 2015.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Ghebrehiwet B, Zaniewski M, Fernandez A,
DiGiovanni M, Reyes TN, Ji P, Savitt AG, Williams JL, Seeliger MA
and Peerschke EIB: The C1q and gC1qR axis as a novel checkpoint
inhibitor in cancer. Front Immunol. 15(1351656)2024.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Wang Q, Chai D, Sobhani N, Sun N, Neeli P,
Zheng J and Tian H: C1QBP regulates mitochondrial plasticity to
impact tumor progression and antitumor immune response. Front
Physiol. 13(1012112)2022.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Ghebrehiwet B, Lim BL, Peerschke EI and
Reid KB: Isolation, cDNA cloning, and overexpression of a 33-kD
cell surface glycoprotein that binds to the globular ‘heads’ of
C1q. J Exp Med. 179:1809–1821. 1994.PubMed/NCBI View Article : Google Scholar
|
|
9
|
George SA, Kotapalli V, Ramaswamy P, Kumar
R, Gowrishankar S, Uppin SG and Bashyam MD: Novel oncogenic
transcriptional targets of mutant p53 in esophageal squamous cell
carcinoma. J Cell Biochem. 125(e30534)2024.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Guo N, Weremowicz S, Lynch N, Lim BL,
Schwaeble W, Peerschke EI, Morton CC, Reid KB, Ghebrehiwet B and
Sastry KN: Assignment of C1QBP encoding the C1q globular domain
binding protein (gC1q-R) to human chromosome 17 band p13.3 by in
situ hybridization. Cytogenet Cell Genet. 77:283–284.
1997.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Jiang J, Zhang Y, Krainer AR and Xu R:
Crystal structure of human p32, a doughnut-shaped acidic
mitochondrial matrix protein. Proc Natl Acad Sci USA. 96:3572–3577.
1999.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Ghebrehiwet B, Geisbrecht BV, Xu X, Savitt
AG and Peerschke EIB: The C1q receptors: Focus on gC1qR/p33 (C1qBP,
p32, HABP-1)1. Semin Immunol. 45(101338)2019.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Rangsee N, Yanatatsaneejit P, Pisitkun T,
Somparn P, Jintaridth P and Topanurak S: Host proteome linked to
HPV E7-mediated specific gene hypermethylation in cancer pathways.
Infect Agent Cancer. 15(7)2020.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Sengupta A, Banerjee B, Tyagi RK and Datta
K: Golgi localization and dynamics of hyaluronan binding protein 1.
Cell Res. 15:183–186. 2005.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Hu M, Crawford SA, Henstridge DC, Ng IH,
Boey EJ, Xu Y, Febbraio MA, Jans DA and Bogoyevitch MA: p32 protein
levels are integral to mitochondrial and endoplasmic reticulum
morphology, cell metabolism and survival. Biochem J. 453:381–391.
2013.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Fogal V, Richardson AD, Karmali PP,
Scheffler IE, Smith JW and Ruoslahti E: Mitochondrial p32 protein
is a critical regulator of tumor metabolism via maintenance of
oxidative phosphorylation. Mol Cell Biol. 30:1303–1318.
2023.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Gotoh K, Morisaki T, Setoyama D, Sasaki K,
Yagi M, Igami K, Mizuguchi S, Uchiumi T, Fukui Y and Kang D:
Mitochondrial p32/C1qbp is a critical regulator of dendritic cell
metabolism and maturation. Cell Rep. 25:1800–1815.e1804.
2018.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Dempsey PW, Allison ME, Akkaraju S,
Goodnow CC and Fearon DT: C3d of complement as a molecular
adjuvant: Bridging innate and acquired immunity. Science.
271:348–350. 1996.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Botto M, Dell'Agnola C, Bygrave AE,
Thompson EM, Cook HT, Petry F, Loos M, Pandolfi PP and Walport MJ:
Homozygous C1q deficiency causes glomerulonephritis associated with
multiple apoptotic bodies. Nat Genet. 19:56–59. 1998.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Muta T, Kang D, Kitajima S, Fujiwara T and
Hamasaki N: p32 protein, a splicing factor 2-associated protein, is
localized in mitochondrial matrix and is functionally important in
maintaining oxidative phosphorylation. J Biol Chem.
272:24363–24370. 1997.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Krainer A, Mayeda A, Kozak D and Binns G:
Functional expression of cloned human splicing factor SF2-homology
to RNA-binding proteins, U1 70K, and Drosophila splicing
regulators. Cell. 66:383–394. 1991.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Honor B, Madsena P, Rasmusserf HH,
Vandekerckhove J, Celis JE and Leffers H: Cloning and expression of
a cDNA covering the complete coding region of the P32 subunit of
human pre-mRNA splicing factor SF2. Gene. 134:283–287.
1993.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Peerschke EI, Petrovan RJ, Ghebrehiwet B
and Ruf W: Tissue factor pathway inhibitor-2 (TFPI-2) recognizes
the complement and kininogen binding protein gC1qR/p33 (gC1qR):
Implications for vascular inflammation. Thromb Haemost. 92:811–819.
2004.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Xu L, Xiao N, Liu F, Ren H and Gu J:
Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR
at mitochondria. Proc Natl Acad Sci USA. 106:1530–1535.
2009.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Song K, Wu Y, Fu B, Wang L, Hao W, Hua F,
Sun Y, Dorf ME and Li S: Leaked mitochondrial C1QBP inhibits
activation of the DNA sensor cGAS. J Immunol. 207:2155–2166.
2021.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Biswas AK, Hafiz A, Banerjee B, Kim KS,
Datta K and Chitnis CE: Plasmodium falciparum uses gC1qR/HABP1/p32
as a receptor to bind to vascular endothelium and for
platelet-mediated clumping. PLoS Pathog. 3:1271–1280.
2007.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Egusquiza-Alvarez CA and Robles-Flores M:
An approach to p32/gC1qR/HABP1: A multifunctional protein with an
essential role in cancer. J Cancer Res Clin Oncol. 148:1831–1854.
2022.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Feng X, Tonnesen MG, Peerschke EI and
Ghebrehiwet B: Cooperation of C1q receptors and integrins in
C1q-mediated endothelial cell adhesion and spreading. J Immunol.
168:2441–2448. 2002.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Deb TB and Datta K: Molecular cloning of
human fibroblast hyaluronic acid-binding protein confirms its
identity with P-32, a protein co-purified with splicing factor SF2.
Hyaluronic acid-binding protein as P-32 protein, co-purified with
splicing factor SF2. J Biol Chem. 271:2206–2212. 1996.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Petersen-Mahrt SK, Estmer C, Ohrmalm C,
Matthews DA, Russell WC and Akusjärvi G: The splicing
factor-associated protein, p32, regulates RNA splicing by
inhibiting ASF/SF2 RNA binding and phosphorylation. EMBO J.
18:1014–1024. 1999.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Shi H, Fang W, Liu M and Fu D: Complement
component 1, q subcomponent binding protein (C1QBP) in lipid rafts
mediates hepatic metastasis of pancreatic cancer by regulating
IGF-1/IGF-1R signaling. Int J Cancer. 141:1389–1401.
2017.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Wang Z, Sun A, Yan A, Yao J, Huang H, Gao
Z, Han T, Gu J, Li N, Wu H and Li K: Circular RNA MTCL1 promotes
advanced laryngeal squamous cell carcinoma progression by
inhibiting C1QBP ubiquitin degradation and mediating beta-catenin
activation. Mol Cancer. 21(92)2022.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Ma J, Ren C, Yang H, Zhao J, Wang F and
Wan Y: The expression pattern of p32 in sheep muscle and its role
in differentiation, cell proliferation, and apoptosis of myoblasts.
Int J Mol Sci. 20(5161)2019.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Wu H, Chu Y, Sun S, Li G, Xu S, Zhang X,
Jiang Y, Gao S, Wang Q, Zhang J and Pang D: Hypoxia-mediated
complement 1q binding protein regulates metastasis and
chemoresistance in triple-negative breast cancer and modulates the
PKC-NF-κB-VCAM-1 signaling pathway. Front Cell Dev Biol.
9(607142)2021.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Sünderhauf A, Hicken M, Schlichting H,
Skibbe K, Ragab M, Raschdorf A, Hirose M, Schäffler H, Bokemeyer A,
Bettenworth D, et al: Loss of Mucosal p32/gC1qR/HABP1 triggers
energy deficiency and impairs goblet cell differentiation in
ulcerative colitis. Cell Mol Gastroenterol Hepatol. 12:229–250.
2021.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Kaul R, Saha P, Saradhi M, Prasad RL,
Chatterjee S, Ghosh I, Tyagi RK and Datta K: Overexpression of
hyaluronan-binding protein 1 (HABP1/p32/gC1qR) in HepG2 cells leads
to increased hyaluronan synthesis and cell proliferation by
up-regulation of cyclin D1 in AKT-dependent pathway. J Biol Chem.
287:19750–19764. 2012.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Egusquiza-Alvarez CA, Moreno-Londoño AP,
Alvarado-Ortiz E, Ramos-Godínez MDP, Sarabia-Sánchez MA,
Castañeda-Patlán MC and Robles-Flores M: Inhibition of
multifunctional protein p32/C1QBP promotes cytostatic effects in
colon cancer cells by altering mitogenic signaling pathways and
promoting mitochondrial damage. Int J Mol Sci.
25(2712)2024.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Krust B, El Khoury D, Nondier I,
Soundaramourty C and Hovanessian AG: Targeting surface nucleolin
with multivalent HB-19 and related Nucant pseudopeptides results in
distinct inhibitory mechanisms depending on the malignant tumor
cell type. BMC Cancer. 11(333)2011.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Dembitzer FR, Kinoshita Y, Burstein D,
Phelps RG, Beasley MB, Garcia R, Harpaz N, Jaffer S, Thung SN,
Unger PD, et al: gC1qR expression in normal and pathologic human
tissues: differential expression in tissues of epithelial and
mesenchymal origin. J Histochem Cytochem. 60:467–474.
2012.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Xie Z, Gao Y, Ho C, Li L, Jin C, Wang X,
Zou C, Mao Y, Wang X, Li Q, et al: Exosome-delivered CD44v6/C1QBP
complex drives pancreatic cancer liver metastasis by promoting
fibrotic liver microenvironment. Gut. 71:568–579. 2022.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Bai Y, Wang W, Li S, Zhan J, Li H, Zhao M,
Zhou XA, Li S, Li X, Huo Y, et al: C1QBP promotes homologous
recombination by stabilizing MRE11 and controlling the assembly and
activation of MRE11/RAD50/NBS1 complex. Mol Cell.
75:1299–1314.e1296. 2019.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Chastney MR, Kaivola J, Leppänen VM and
Ivaska J: The role and regulation of integrins in cell migration
and invasion. Nat Rev Mol Cell Biol. 26:147–167. 2025.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Li X, Wu Y, Zhang M, Wang F, Yin H, Zhang
Y, Zhao S, Ma J, Lv M and Lu C: A new peptide inhibitor of C1QBP
exhibits potent anti-tumour activity against triple negative breast
cancer by impairing mitochondrial function and suppressing
homologous recombination repair. Clin Transl Med.
15(e70162)2025.PubMed/NCBI View Article : Google Scholar
|
|
44
|
Kerdidani D, Aerakis E, Verrou KM,
Angelidis I, Douka K, Maniou MA, Stamoulis P, Goudevenou K, Prados
A, Tzaferis C, et al: Lung tumor MHCII immunity depends on in situ
antigen presentation by fibroblasts. J Exp Med.
219(e20210815)2022.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Cheng X, Wang M, Li W, Tian B, Zhang J,
Zhang C and Liu P: C1QBP forms a positive feedback loop with the
PAICS/FAK/C-MYC axis to promote cancer cell proliferation.
Oncogene. 44:4363–4376. 2025.PubMed/NCBI View Article : Google Scholar
|
|
46
|
Prakash M, Kale S, Ghosh I, Kundu GC and
Datta K: Hyaluronan-binding protein 1 (HABP1/p32/gC1qR) induces
melanoma cell migration and tumor growth by NF-kappa B dependent
MMP-2 activation through integrin α(v)β(3) interaction. Cell
Signal. 23:1563–1577. 2011.PubMed/NCBI View Article : Google Scholar
|
|
47
|
Yue D, Wang Y, Sun Y, Niu Y and Chang C:
C1QBP regulates YBX1 to suppress the androgen receptor
(AR)-enhanced RCC cell invasion. Neoplasia. 19:135–144.
2017.PubMed/NCBI View Article : Google Scholar
|
|
48
|
Wang Y, Yue D, Xiao M, Qi C, Chen Y, Sun
D, Zhang N and Chen R: C1QBP negatively regulates the activation of
oncoprotein YBX1 in the renal cell carcinoma as revealed by
interactomics analysis. J Proteome Res. 14:804–813. 2015.PubMed/NCBI View Article : Google Scholar
|
|
49
|
Leucci E, Vendramin R, Spinazzi M,
Laurette P, Fiers M, Wouters J, Radaelli E, Eyckerman S, Leonelli
C, Vanderheyden K, et al: Melanoma addiction to the long non-coding
RNA SAMMSON. Nature. 531:518–522. 2016.PubMed/NCBI View Article : Google Scholar
|
|
50
|
Sinha S, Singh SK, Jangde N, Ray R and Rai
V: p32 promotes melanoma progression and metastasis by targeting
EMT markers, Akt/PKB pathway, and tumor microenvironment. Cell
Death Dis. 12(1012)2021.PubMed/NCBI View Article : Google Scholar
|
|
51
|
Qin X, Kang K, Zhu B, Shi Y and Bu S:
C1QBP drives M2 macrophage polarization via TRAF2-CCL2 to promote
oral squamous cell carcinoma progression. Int Dent J.
75(103938)2025.PubMed/NCBI View Article : Google Scholar
|
|
52
|
Zhang S, Wang C, Wang Y, Zhang H, Xu C,
Cheng Y, Yuan Y, Sha J, Guo X and Cui Y: A novel protein encoded by
circRsrc1 regulates mitochondrial ribosome assembly and translation
during spermatogenesis. BMC Biol. 21(94)2023.PubMed/NCBI View Article : Google Scholar
|
|
53
|
Becker YLC, Gagné JP, Julien AS, Lévesque
T, Allaeys I, Gougeard N, Rubio V, Boisvert FM, Jean D, Wagner E,
et al: Identification of Mitofusin 1 and complement component 1q
subcomponent binding protein as mitochondrial targets in systemic
lupus erythematosus. Arthritis Rheumatol. 74:1193–1203.
2022.PubMed/NCBI View Article : Google Scholar
|
|
54
|
Duan Y, Yang Y, Zhu R and Xiao M:
Endotoxin lipopolysaccharide challenge triggers gut microbiota
dysbiosis and host immune remodeling in the tiger grouper
Epinephelus fuscoguttatus. Comp Biochem Physiol C Toxicol
Pharmacol. 299(110364)2026.PubMed/NCBI View Article : Google Scholar
|
|
55
|
Wang SQ, Jin MJ, Guo ZK, Shen DR, Jin LN,
Cheng F, Zhao YR, Liu T, Li YC, Wang NY, et al: Trace
element-dictated exosome modules and self-adaptive dual-network
hydrogel orchestrate diabetic foot regeneration through
complement-mitochondria-autophagy circuitry. Mil Med Res.
12(71)2025.PubMed/NCBI View Article : Google Scholar
|
|
56
|
Zhai X, Liu K, Fang H, Zhang Q, Gao X, Liu
F, Zhou S, Wang X, Niu Y, Hong Y, et al: Mitochondrial C1qbp
promotes differentiation of effector CD8(+) T cells via
metabolic-epigenetic reprogramming. Sci Adv.
7(eabk0490)2021.PubMed/NCBI View Article : Google Scholar
|
|
57
|
Feichtinger RG, Oláhová M, Kishita Y,
Garone C, Kremer LS, Yagi M, Uchiumi T, Jourdain AA, Thompson K,
D'Souza AR, et al: Biallelic C1QBP mutations cause severe
Neonatal-, Childhood-, or later-onset cardiomyopathy associated
with combined respiratory-chain deficiencies. Am J Hum Genet.
101:525–538. 2017.PubMed/NCBI View Article : Google Scholar
|
|
58
|
Yenugonda V, Nomura N, Kouznetsova V,
Tsigelny I, Fogal V, Nurmemmedov E, Kesari S and Babic I: A novel
small molecule inhibitor of p32 mitochondrial protein overexpressed
in glioma. J Transl Med. 15(210)2017.PubMed/NCBI View Article : Google Scholar
|
|
59
|
Reef S, Shifman O, Oren M and Kimchi A:
The autophagic inducer smARF interacts with and is stabilized by
the mitochondrial p32 protein. Oncogene. 26:6677–6683.
2007.PubMed/NCBI View Article : Google Scholar
|
|
60
|
Bi Q, Nie J, Wu Q, Sun L, Zhu S, Bai J,
Liu Y, Huang F and Chai K: Integrative pan-cancer genomic analysis
highlights mitochondrial protein p32 as a potential therapeutic
target in Myc-driven tumorigenesis. Med Oncol.
42(60)2025.PubMed/NCBI View Article : Google Scholar
|
|
61
|
Wen X, Li W, Li S, Chen D, Zheng J, Wang
X, Zhang C, Liu Y, Ning Y, Jia R, et al: Longitudinal single-cell
RNA sequencing reveals a heterogeneous response of plasma cells to
colonic inflammation. Int J Biol Macromol.
294(139307)2025.PubMed/NCBI View Article : Google Scholar
|
|
62
|
Mizuguchi S, Gotoh K, Nakashima Y,
Setoyama D, Takata Y, Ohga S and Kang D: Mitochondrial reactive
oxygen species are essential for the development of psoriatic
inflammation. Front Immunol. 12(714897)2021.PubMed/NCBI View Article : Google Scholar
|
|
63
|
Yao ZQ, Prayther D, Trabue C, Dong ZP and
Moorman J: Differential regulation of SOCS-1 signalling in B and T
lymphocytes by hepatitis C virus core protein. Immunology.
125:197–207. 2008.PubMed/NCBI View Article : Google Scholar
|
|
64
|
Yao ZQ, Eisen-Vandervelde A, Waggoner SN,
Cale EM and Hahn YS: Direct binding of hepatitis C virus core to
gC1qR on CD4+ and CD8+ T cells leads to impaired activation of Lck
and Akt. J Virol. 78:6409–6419. 2004.PubMed/NCBI View Article : Google Scholar
|
|
65
|
Mumme H, Thomas BE, Bhasin SS, Krishnan U,
Dwivedi B, Perumalla P, Sarkar D, Ulukaya GB, Sabnis HS, Park SI,
et al: Single-cell analysis reveals altered tumor microenvironments
of relapse- and remission-associated pediatric acute myeloid
leukemia. Nat Commun. 14(6209)2023.PubMed/NCBI View Article : Google Scholar
|
|
66
|
Tian H, Wang G, Wang Q, Zhang B, Jiang G,
Li H, Chai D, Fang L, Wang M and Zheng J: Complement C1q binding
protein regulates T cells' mitochondrial fitness to affect their
survival, proliferation, and anti-tumor immune function. Cancer
Sci. 113:875–890. 2022.PubMed/NCBI View Article : Google Scholar
|
|
67
|
Zhang C, Liu Y, Jiang J, Chen C, Duan Z,
Su H, Wang S, Tian B, Shi Y, Xiang R and Luo Y: Targeting tumor
cell-to-macrophage communication by blocking Vtn-C1qbp interaction
inhibits tumor progression via enhancing macrophage phagocytosis.
Theranostics. 14:2757–2776. 2024.PubMed/NCBI View Article : Google Scholar
|
|
68
|
Wu X, Tang N, Zhao Q and Xiong J:
Spatiotemporal evolutionary process of osteosarcoma immune
microenvironment remodeling and C1QBP-driven drug resistance
deciphered through single-cell multi-dimensional analysis. Bioeng
Transl Med. 9(e10654)2024.PubMed/NCBI View Article : Google Scholar
|
|
69
|
Piltti KM, Lakatos A, Benavente-Perez F,
Elrachid ZH, Nava AA, Addonizio NT, Nguyen V, Zahedi A, Song WA,
Chen X, et al: C1q drives neural stem cell quiescence by regulating
cell cycle and metabolism through BAI1. Nat Commun.
16(11386)2025.PubMed/NCBI View Article : Google Scholar
|
|
70
|
Ghose S, Biswas S, Datta K and Tyagi RK:
Dynamic Hyaluronan drives liver endothelial cells towards
angiogenesis. BMC Cancer. 18(648)2018.PubMed/NCBI View Article : Google Scholar
|
|
71
|
Peerschke EI and Ghebrehiwet B: cC1qR/CR
and gC1qR/p33: Observations in cancer. Mol Immunol. 61:100–109.
2014.PubMed/NCBI View Article : Google Scholar
|
|
72
|
Dong X, Liu Z, Yu M, Yang X and Cai H:
Identification of the whole genome of alternative splicing and
RNA-binding proteins involved in nintedanib-induced apoptosis in
gastric cancer cells. PeerJ. 12(e18697)2024.PubMed/NCBI View Article : Google Scholar
|
|
73
|
Rousso-Noori L, Mastandrea I, Talmor S,
Waks T, Levin AG, Haugas M, Teesalu T, Alvarez-Vallina L, Eshhar Z
and Friedmann-Morvinski D: P32-specific CAR T cells with dual
antitumor and antiangiogenic therapeutic potential in gliomas. Nat
Commun. 12(3615)2021.PubMed/NCBI View Article : Google Scholar
|
|
74
|
Lei Y, Li X, Qin D, Zhang Y and Wang Y:
gC1qR: A new target for cancer immunotherapy. Front Immunol.
14(1095943)2023.PubMed/NCBI View Article : Google Scholar
|
|
75
|
Momenimovahed Z, Mazidimoradi A, Maroofi
P, Allahqoli L, Salehiniya H and Alkatout I: Global, regional and
national burden, incidence, and mortality of cervical cancer.
Cancer Rep (Hoboken). 6(e1756)2023.PubMed/NCBI View Article : Google Scholar
|
|
76
|
Burd EM: Human papillomavirus and cervical
cancer. Clin Microbiol Rev. 16:1–17. 2003.PubMed/NCBI View Article : Google Scholar
|
|
77
|
Gao LJ, Gu PQ, Zhao W, Ding WY, Zhao XQ,
Guo SY and Zhong TY: The role of globular heads of the C1q receptor
in HPV 16 E2-induced human cervical squamous carcinoma cell
apoptosis is associated with p38 MAPK/JNK activation. J Transl Med.
11(118)2013.PubMed/NCBI View Article : Google Scholar
|
|
78
|
Chen ZL, Su YJ, Zhang HL, Gu PQ and Gao
LJ: The role of the globular heads of the C1q receptor in HPV-16
E2-induced human cervical squamous carcinoma cell apoptosis via a
mitochondria-dependent pathway. J Transl Med.
12(286)2014.PubMed/NCBI View Article : Google Scholar
|
|
79
|
Gao LJ, Gu PQ, Fan WM, Liu Z, Qiu F, Peng
YZ and Guo XR: The role of gC1qR in regulating survival of human
papillomavirus 16 oncogene-transfected cervical cancer cells. Int J
Oncol. 39:1265–1272. 2011.PubMed/NCBI View Article : Google Scholar
|
|
80
|
Itahana K and Zhang Y: Mitochondrial p32
is a critical mediator of ARF-induced apoptosis. Cancer Cell.
13:542–553. 2008.PubMed/NCBI View Article : Google Scholar
|
|
81
|
Liu Z, Su YJ, Gu PQ, Ji ZY, Wang XG and
Gao LJ: The role of the globular heads of C1q receptor (gC1qR) gene
in regulating apoptosis of human cervical squamous cell carcinoma.
Cell Physiol Biochem. 30:1181–1190. 2012.PubMed/NCBI View Article : Google Scholar
|
|
82
|
Siegel RL, Miller KD, Fuchs HE and Jemel
A: Cancer statistics, 2021. CA Cancer J Clin. 71:7–33.
2021.PubMed/NCBI View Article : Google Scholar
|
|
83
|
Yu G and Wang J: Significance of
hyaluronan binding protein (HABP1/P32/gC1qR) expression in advanced
serous ovarian cancer patients. Exp Mol Pathol. 94:210–215.
2013.PubMed/NCBI View Article : Google Scholar
|
|
84
|
Duan C, Gao Y, Luan S, Guo S, Cao X, Xu P,
Fu P and Zhao C: Noninvasive evaluation of HABP1 expression with
99mTc-labeled small-interference RNA in ovarian cancer. Int J
Radiat Biol. 97:1569–1577. 2021.PubMed/NCBI View Article : Google Scholar
|
|
85
|
Hunt H, Simón-Gracia L, Tobi A, Kotamraju
VR, Sharma S, Nigul M, Sugahara KN, Ruoslahti E and Teesalu T:
Targeting of p32 in peritoneal carcinomatosis with intraperitoneal
linTT1 peptide-guided pro-apoptotic nanoparticles. J Control
Release. 260:142–153. 2017.PubMed/NCBI View Article : Google Scholar
|
|
86
|
Bryce C, Gazda R and Fuerst H: Endometrial
cancer: Rapid evidence review. Am Fam Physician. 111:526–531.
2025.PubMed/NCBI
|
|
87
|
Galani A, Stavros S, Moustakli E, Potiris
A, Zikopoulos A, Anagnostaki I, Zacharis K, Paraskevaidi M, Lyons
D, Maneta-Stavrakaki S, et al: Endometrial hyperplasia: Current
insights into epidemiology, risk factors, and clinical management.
Cancers (Basel), 2025, 18(1).
|
|
88
|
Zheng Y, Hu R, Yang F, Liu G, Peng T, Xie
L, Wu J, Hou L and Yuan R: Comparing survival outcomes between
surgical and non-surgical treatments in patients with early-onset
endometrial cancer and developing a nomogram to predict survival: A
study based on Eastern and Western data sets. World J Surg Oncol.
23(184)2025.PubMed/NCBI View Article : Google Scholar
|
|
89
|
Rubinstein DB, Stortchevoi A, Boosalis M,
Ashfaq R, Ghebrehiwet B, Peerschke EI, Calvo F and Guillaume T:
Receptor for the globular heads of C1q (gC1q-R, p33,
hyaluronan-binding protein) is preferentially expressed by
adenocarcinoma cells. Int J Cancer. 110:741–750. 2004.PubMed/NCBI View Article : Google Scholar
|
|
90
|
Yang M, Hu Y, Guo W, Yang F, Qi X and
Zheng Y: Causal relationship between components of metabolic
syndrome and endometrial carcinoma. Sichuan Da Xue Xue Bao Yi Xue
Ban. 55:1557–1566. 2024.PubMed/NCBI View Article : Google Scholar : (In Chinese).
|
|
91
|
Pérez-Martín AR, Castro-Eguiluz D,
Cetina-Pérez L, Velasco-Torres Y, Bahena-González A, Montes-Servín
E, González-Ibarra E, Espinosa-Romero R and Gallardo-Rincón D:
Impact of metabolic syndrome on the risk of endometrial cancer and
the role of lifestyle in prevention. Bosn J Basic Med Sci.
22:499–510. 2022.PubMed/NCBI View Article : Google Scholar
|
|
92
|
de Boer SM, Powell ME, Mileshkin L,
Katsaros D, Bessette P, Haie-Meder C, Ottevanger PB, Ledermann JA,
Khaw P, D'Amico R, et al: Adjuvant chemoradiotherapy versus
radiotherapy alone in women with high-risk endometrial cancer
(PORTEC-3): patterns of recurrence and post-hoc survival analysis
of a randomised phase 3 trial. Lancet Oncol. 20:1273–1285.
2019.PubMed/NCBI View Article : Google Scholar
|
|
93
|
Ryu KJ, Kim MS, Lee JY, Nam S, Jeong HG,
Kim T and Park H: Risk of endometrial polyps, hyperplasia,
carcinoma, and uterine cancer after tamoxifen treatment in
premenopausal women with breast cancer. JAMA Netw Open.
5(e2243951)2022.PubMed/NCBI View Article : Google Scholar
|
|
94
|
Katagiri R, Iwasaki M, Abe SK, Islam MR,
Rahman MS, Saito E, Merritt MA, Choi JY, Shin A, Sawada N, et al:
Reproductive factors and endometrial cancer risk among women. JAMA
Netw Open. 6(e2332296)2023.PubMed/NCBI View Article : Google Scholar
|
|
95
|
Liang J and Shang Y: Estrogen and cancer.
Annu Rev Physiol. 75:225–240. 2013.PubMed/NCBI View Article : Google Scholar
|
|
96
|
Hu Z, Tang M, Huang Y, Cai B, Sun X, Chen
G, Huang A, Li X, Shah AR, Jiang L, et al: SIRT7 facilitates
endometrial cancer progression by regulating PTEN stability in an
estrogen-dependent manner. Nat Commun. 16(2989)2025.PubMed/NCBI View Article : Google Scholar
|
|
97
|
Thakur SC, Kumar V, Ghosh I, Bharadwaj A
and Datta K: Appearance of hyaluronan binding protein 1 proprotein
in pachytene spermatocytes and round spermatids correlates with
spermatogenesis. J Androl. 27:604–610. 2006.PubMed/NCBI View Article : Google Scholar
|
|
98
|
Xiao S, Xu C and Jarvis JN: C1q-bearing
immune complexes induce IL-8 secretion in human umbilical vein
endothelial cells (HUVEC) through protein tyrosine kinase- and
mitogen-activated protein kinase-dependent mechanisms: evidence
that the 126 kD phagocytic C1q receptor mediates immune complex
activation of HUVEC. Clin Exp Immunol. 125:360–367. 2001.PubMed/NCBI View Article : Google Scholar
|
|
99
|
Dong M, Seemann F, Humble JL, Liang Y,
Peterson DR, Ye R, Ren H, Kim HS, Lee JS, Au DWT and Lam YW:
Modification of the plasma complement protein profile by exogenous
estrogens is indicative of a compromised immune competence in
marine medaka (Oryzias melastigma). Fish Shellfish Immunol.
70:260–269. 2017.PubMed/NCBI View Article : Google Scholar
|
|
100
|
Wu Y, Li X, Hou Y, Lv M and Zhao S:
Targeting the KRAS-p38-ATF4 axis enhances the therapeutic
sensitivity of the peptide PDBAG1 in ovarian cancer via stress
response modulation. Eur J Pharmacol. 1006(178128)2025.PubMed/NCBI View Article : Google Scholar
|
|
101
|
Liu Y, Leslie PL, Jin A, Itahana K, Graves
LM and Zhang Y: p32 heterozygosity protects against age- and
diet-induced obesity by increasing energy expenditure. Sci Rep.
7(5754)2017.PubMed/NCBI View Article : Google Scholar
|
|
102
|
Liu Y, Leslie PL, Jin A, Itahana K, Graves
LM and Zhang Y: p32 regulates ER stress and lipid homeostasis by
down-regulating GCS1 expression. FASEB J. 32:3892–3902.
2018.PubMed/NCBI View Article : Google Scholar
|
|
103
|
van den Heerik A, Horeweg N, de Boer SM,
Bosse T and Creutzberg CL: Adjuvant therapy for endometrial cancer
in the era of molecular classification: Radiotherapy,
chemoradiation and novel targets for therapy. Int J Gynecol Cancer.
31:594–604. 2021.PubMed/NCBI View Article : Google Scholar
|
|
104
|
Wang J, Shi Y, Wang Y, Shen Y, Liu H, Sun
S, Wang Y, Zhou X, Zhou Y, Zeng X, et al: PA28γ promotes the
malignant progression of tumor by elevating mitochondrial function
via C1QBP. Elife. 13(RP101244)2025.PubMed/NCBI View Article : Google Scholar
|
|
105
|
Yagi M, Uchiumi T, Takazaki S, Okuno B,
Nomura M, Yoshida S, Kanki T and Kang D: p32/gC1qR is indispensable
for fetal development and mitochondrial translation: Importance of
its RNA-binding ability. Nucleic Acids Res. 40:9717–9737.
2012.PubMed/NCBI View Article : Google Scholar
|
|
106
|
Wang Z, Chen J, Wu X, Ma D, Zhang X, Li R,
Han C, Liu H, Yin X, Du Q, et al: PCV2 targets cGAS to inhibit type
I interferon induction to promote other DNA virus infection. PLoS
Pathog. 17(e1009940)2021.PubMed/NCBI View Article : Google Scholar
|
|
107
|
Song N, Zhao L, Zhu M and Zhao J: Recent
progress in LyP-1-based strategies for targeted imaging and
therapy. Drug Deliv. 26:363–375. 2019.PubMed/NCBI View Article : Google Scholar
|
|
108
|
Jenkins MR and Drummond KJ: CAR T-cell
therapy for glioblastoma. N Engl J Med. 390:1329–1332.
2024.PubMed/NCBI View Article : Google Scholar
|
|
109
|
Bagley SJ, Logun M, Fraietta JA, Wang X,
Desai AS, Bagley LJ, Nabavizadeh A, Jarocha D, Martins R, Maloney
E, et al: Intrathecal bivalent CAR T cells targeting EGFR and
IL13Rα2 in recurrent glioblastoma: Phase 1 trial interim results.
Nat Med. 30:1320–1329. 2024.PubMed/NCBI View Article : Google Scholar
|
|
110
|
Choe JH, Watchmaker PB, Simic MS, Gilbert
RD, Li AW, Krasnow NA, Downey KM, Yu W, Carrera DA, Celli A, et al:
SynNotch-CAR T cells overcome challenges of specificity,
heterogeneity, and persistence in treating glioblastoma. Sci Transl
Med. 13(eabe7378)2021.PubMed/NCBI View Article : Google Scholar
|
|
111
|
Cai G, Huang F, Gao Y, Li X, Chi J, Xie J,
Zhou L, Feng Y, Huang H, Deng T, et al: Artificial
intelligence-based models enabling accurate diagnosis of ovarian
cancer using laboratory tests in China: A multicentre,
retrospective cohort study. Lancet Digit Health. 6:e176–e186.
2024.PubMed/NCBI View Article : Google Scholar
|
|
112
|
Njoku K, Barr CE, Sutton CJJ and Crosbie
EJ: Urine CA125 and HE4 for the triage of symptomatic women with
suspected endometrial cancer. Cancers (Basel).
14(3306)2022.PubMed/NCBI View Article : Google Scholar
|
|
113
|
Scully OJ, Shyamasundar S, Matsumoto K,
Dheen ST, Yip GW and Bay BH: C1QBP Mediates breast cancer cell
proliferation and growth via multiple potential signalling
pathways. Int J Mol Sci. 24(1343)2023.PubMed/NCBI View Article : Google Scholar
|
|
114
|
Sonveaux P, Végran F, Schroeder T, Wergin
MC, Verrax J, Rabbani ZN, De Saedeleer CJ, Kennedy KM, Diepart C,
Jordan B, et al: Targeting lactate-fueled respiration selectively
kills hypoxic tumor cells in mice. J Clin Invest. 118:3930–3942.
2008.PubMed/NCBI View Article : Google Scholar
|
