|
1
|
McKinnon C, Nandhabalan M, Murray SA and
Plaha P: Glioblastoma: Clinical presentation, diagnosis, and
management. BMJ. 374(n1560)2021.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Tan SK, Jermakowicz A, Mookhtiar AK,
Nemeroff CB, Schürer SC and Ayad NG: Drug repositioning in
glioblastoma: A pathway perspective. Front Pharmacol.
9(218)2018.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Abadi B, Shahsavani Y, Faramarzpour M,
Rezaei N and Rahimi HR: Antidepressants with antitumor potential in
treating glioblastoma: A narrative review. Fundam Clin Pharmacol.
36:35–48. 2022.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Martino M, Rocchi G, Escelsior A and
Fornaro M: Immunomodulation mechanism of antidepressants:
Interactions between serotonin/norepinephrine balance and Th1/Th2
balance. Curr Neuropharmacol. 10:97–123. 2012.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Jia X, Gao Z and Hu H: Microglia in
depression: Current perspectives. Sci China Life Sci. 64:911–925.
2021.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Frizzo ME and Ohno Y: Perisynaptic
astrocytes as a potential target for novel antidepressant drugs. J
Pharmacol Sci. 145:60–68. 2021.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Castren E: Neurotrophic effects of
antidepressant drugs. Curr Opin Pharmacol. 4:58–64. 2004.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Bortolato B, Hyphantis TN, Valpione S,
Perini G, Maes M, Morris G, Kubera M, Köhler CA, Fernandes BS,
Stubbs B, et al: Depression in cancer: The many biobehavioral
pathways driving tumor progression. Cancer Treat Rev. 52:58–70.
2017.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Steingart AB and Cotterchio M: Do
antidepressants cause, promote, or inhibit cancers? J Clin
Epidemiol. 48:1407–1412. 1995.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Dehghani A, Tabaku A and Eshghjoo S: The
tricyclic antidepressant amitriptyline is cytotoxic to human breast
cancer (MCF7) cells. J Biol Stud. 5(1):85–92. 2022.
|
|
11
|
Quail DF and Joyce JA: The
microenvironmental landscape of brain tumors. Cancer Cell.
31:326–341. 2017.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Hab Y, Liu D and Li L: PD-1/PD-L1 pathway:
Current researches in cancer. Am J Cancer Res. 10:727–742.
2020.PubMed/NCBI
|
|
13
|
Dunai C and Murphy WJ: NK cells for
PD-1/PD-L1 blockade immunotherapy: Pinning down the NK cell. J Clin
Invest. 128:4251–4253. 2018.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Wu J and Wang N: Current progress of
antiPD1/PDL1 immunotherapy for glioblastoma (Review). Mol Med Rep.
30(221)2024.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Zeng YF, Wei XY, Guo QH, Chen SY, Deng S,
Liu ZZ, Gong ZC and Zeng WJ: The efficacy and safety of
anti-PD-1/PD-L1 in treatment of glioma: A single-arm meta-analysis.
Front Immunol. 14(1168244)2023.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Bielecka AM and Obuchowicz E: Chronic
physiological hypoxia and high glucose concentration promote
resistance of T98G glioblastoma cell line to temozolomide. Drug
Des. 3(117)2014.
|
|
17
|
Horan NA and Pugh TM: Intractable central
pain in a patient with diffuse glioma. Am J Phys Med Rehabil.
98:e107–e110. 2019.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Sindrup SH, Otto M, Finnerup NB and Jensen
TS: Antidepressants in the treatment of neuropathic pain. Basic
Clin Pharmacol Toxicol. 96:399–409. 2005.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Gałecki P, Wójcik JM and Talarowska M: The
anti-inflammatory mechanism of antidepressants. Prog
Neuropsychopharmacol Biol Psychiatry. 80:291–294. 2018.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Miyake K, Fukuchi K, Kitaura T, Kimura M
and Kimura Y: Pharmacokinetic analysis of amitriptyline and its
demethylated metabolite in serum and brain of rats after acute and
chronic oral administration of amitriptyline. J Pharmacobiodyn.
15:157–166. 1992.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Shulz P, Dick P, Blaschke TF and Hollister
L: Discrepancies between pharmacokinetic studies of amitriptyline.
Clin Pharmacokinet. 10:257–268. 1985.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Daniel WA, Syrek M, Haduch A and
Wójcikowski J: Different effects of amitriptyline and imipramine on
the pharmacokinetics and metabolism of perazine in rats. J Pharm
Pharmacol. 52:1473–1481. 2000.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Morgan MA and Lawrence TS: Molecular
pathways: Overcoming radiation resistance by targeting DNA damage
response pathways. Clin Cancer Res. 21:2898–2904. 2021.PubMed/NCBI View Article : Google Scholar
|
|
24
|
West AJ, Tsui V, Stylli SS, Nguyen HPT,
Morokoff AP, Kaye AH and Luwor RB: The role of interleukin-6-STAT3
signalling in glioblastoma. Oncol Lett. 16:4095–4104.
2018.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Singh M, Raghaw A and Gautam KA: Role of
the circulatory interleukin-6 in the pathogenesis of gliomas: A
systematic review. World J Methodol. 12:428–437. 2022.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Jiang S, Shi D, Bai L, Niu T, Kang R and
Liu Y: Inhibition of interleukin-6 trans-signaling improves
survival and prevents cognitive impairment in a mouse model of
sepsis. Int Immunopharmacol. 119(110169)2023.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Cruz-Garcia L, Nasser F, O'Brien G, Grepl
J, Vinnikov V, Starenkiy V, Artiukh S, Gramatiuk S and Badie C:
Transcriptional dynamics of DNA damage responsive genes in
circulating leukocytes during radiotherapy. Cancers (Basel).
14(2649)2022.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Serizawa K, Tomizawa-Shinohara H, Miyake
S, Yogo K and Matsumoto Y: Interleukin-6: Evolving role in the
management of neuropathic pain in neuroimmunological disorders.
Inflamm Regen. 41(34)2021.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Amdekar S, Roy P, Singh V, Kumar A, Singh
R and Sharma P: Anti-inflammatory activity of lactobacillus on
carrageenan-induced paw edema in male Wistar rats. Int J Inflam.
2012(752015)2012.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Guo YR, Liu ZW, Peng S, Duan MY, Feng JW,
Wang WF, Xu YH, Tang X, Zhang XZ, Ren BX and Tang FR: The
neuroprotective effect of amitriptyline on radiation-induced
impairment of hippocampal neurogenesis. Dose Response.
17(1559325819895912)2019.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Royds J, Conroy MJ, Dunne MR, McCrory C
and Lysaght J: An investigation into the modulation of T cell
phenotypes by amitriptyline and nortriptyline Eur.
Neuropsychopharmacol. 31:131–144. 2020.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Zaltron E, Vianello F, Ruzza A, Palazzo A,
Brillo V, Celotti I, Scavezzon M, Rossin F, Leanza L and Severin F:
The role of transglutaminase 2 in cancer: An update. Int J Mol Sci.
25(2797)2024.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Li J, Mei B, Feng L, Wang X, Wang D, Huang
J and Zhang G: Amitriptyline revitalizes ICB response via dually
inhibiting Kyn/Indole and 5-HT pathways of tryptophan metabolism in
ovarian cancer. iScience. 27(111488)2024.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Jiang M, Liu C, Ding D, Tian H and Yu C:
Comparative efficacy and safety of Anti-PD-1/PD-L1 for the
Treatment of non-small cell lung cancer: A network meta-analysis of
13 Randomized controlled studies. Front Oncol.
12(827050)2022.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Perrichet A, Ghiringhelli F and Rébé C:
Understanding inflammasomes and PD-1/PD-L1 crosstalk to improve
cancer treatment efficiency. Cancers (Basel).
12(3550)2020.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Bielecka-Wajdman AM, Lesiak M, Ludyga T,
Sieroń A and Obuchowicz E: Reversing glioma malignancy: A new look
at the role of antidepressant drugs as adjuvant therapy for
glioblastoma multiforme. Cancer Chemother Pharmacol. 79:1249–1256.
2017.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Bielecka-Wajdman AM, Ludyga T, Machnik G,
Gołyszny M and Obuchowicz E: Tricyclic antidepressants modulate
stressed mitochondria in glioblastoma multiforme cells. Cancer
Control. 25(1073274818798594)2018.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Obuchowicz E, Kowalski J, Labuzek K,
Krysiak R, Pendzich J and Herman ZS: Amitriptyline and
nortriptyline inhibit interleukin-1 release by rat mixed glial and
microglial cell cultures. Int J Neuropsychopharmacol. 9:27–35.
2006.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Geribaldi-Doldán N, Fernandez-Ponce C,
Quiroz RN, Sanchez-Gomar I, Escorcia LG, Velasquez EP and Qiiroz
EN: The role of microglia in glioblastoma. Front.Oncol.
10(603495)2021.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Li W, Wu F, Zhao S, Shi P, Wang S and Cui
D: Correlation between PD-1/PD-L1 expression and polarization in
tumor-associated macrophages: A key player in tumor immunotherapy.
Cytokine Growth Factor Rev. 67:49–57. 2022.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Wang Y, Zhou S, Yang F, Qi X, Wang X, Guan
X, Shen C, Duma N, Vera Aguilera J, Chintakuntlawar A, et al:
Treatment-related adverse events of PD-1 and PD-L1 inhibitors in
clinical trials: A systematic review and meta-analysis. JAMA Oncol.
5:1008–1019. 2019.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Xing Y, Chand G, Liu C, Cook GJR,
O'Doherty J, Zhao L, Wong NCL, Meszaros LK, Ting HH and Zhao J:
Early phase I Study of a Tc-Labeled anti-programmed death ligand-1
(PD-L1) single-domain antibody in SPECT/CT assessment of PD-L1
expression in non-small cell lung cancer. J Nucl Med. 60:1213–1220.
2019.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Park B, Yee C and Lee KM: The effect of
radiation on the immune response to cancers. Int J Mol Sci.
15:927–943. 2014.PubMed/NCBI View Article : Google Scholar
|
|
44
|
Yang Y, Chen M, Qiu Y, Li X, Huang Y and
Zhang W: The Apelin/APLNR system modulates tumor immune response by
reshaping the tumor microenvironment. Gene.
834(146564)2022.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Snerdi D, Moutafi M, Kotsantis I,
Stavrinou LC and Psyrri A: Overcoming resistance to temozolomide in
glioblastoma: A scoping review of preclinical and clinical data.
Life (Basel). 14(673)2024.PubMed/NCBI View Article : Google Scholar
|
|
46
|
Pineda B, Sánchez García FJ, Olascoaga NK,
Pérez de la Cruz V, Salazar A, Hernández Pedro N, Márquez-Navarro
A, Ortiz Plata A and Sotelo J: Malignant glioma therapy by
vaccination with irradiated C6 cell-derived microvesicles promotes
antitumoral immune response. Mol Ther. 27:1612–1620.
2019.PubMed/NCBI View Article : Google Scholar
|
|
47
|
Gao XY, Zang J, Zheng MH, Zhang YF, Yue
KY, Cao XL, Cao Y, Li XX, Han H, Jiang XF and Liang L: Temozolomide
treatment induces HMGB1 to promote the formation of glioma stem
cells via the TLR2/NEAT1/Wnt pathway in glioblastoma. Front Cell
Dev Biol. 9(620883)2021.PubMed/NCBI View Article : Google Scholar
|
|
48
|
Gogvadze V, Orrenius S and Zhivotovsky B:
Multiple pathways of cytochrome c release from mitochondria in
apoptosis. Biochim Biophys Acta. 1757:639–647. 2006.PubMed/NCBI View Article : Google Scholar
|
|
49
|
Tzadok S, Berry E, Israeli M, Uziel O,
Lahav M, Fenig E, Gil-Ad I, Weizman A and Nordenberg J: In vitro
novel combinations of psychotropics and anticancer modalities in
U87 human glioblastoma cells. Int J Oncol. 37:1043–1051.
2010.PubMed/NCBI View Article : Google Scholar
|
|
50
|
Hu G, Fang Y, Xu H, Wang G, Yang R, Gao F,
Wei Q, Gu Y, Zhang C, Qiu J, et al: Identification of cytochrome
P450 2E1 as a novel target in glioma and development of its
inhibitor as an anti-tumor agent. Adv Sci (Weinh).
10(e2301096)2023.PubMed/NCBI View Article : Google Scholar
|
|
51
|
Hosseinimehr SJ, Najafi SH, Shafiee F,
Hassanzadeh S, Farzipour S, Ghasemi A and Asgarian-Omran H:
Fluoxetine as an antidepressant medicine improves the effects of
ionizing radiation for the treatment of glioma. J Bioenerg
Biomembr. 52:165–174. 2020.PubMed/NCBI View Article : Google Scholar
|
|
52
|
Stupp R, Mason WP, van den Bent MJ, Weller
M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn
U, et al: Radiotherapy plus concomitant and adjuvant temozolomide
for glioblastoma. N Engl J Med. 352:987–996. 2005.PubMed/NCBI View Article : Google Scholar
|
|
53
|
Hu G, Fang Y, Xu H, Wang G, Yang R, Gao F,
Wei Q, Gu Y, Zhang C, et al: Identification of cytochrome P450 2E1
as a novel target in glioma and development of its inhibitor as an
anti-tumor agent. Adv Sci. 23(e2301096)2023.doi:
10.1002/advs.202301096.
|
|
54
|
Kwon Y, Bang Y, Moon SH, Kim A and Choi
HJ: Amitriptyline interferes with autophagy-mediated clearance of
protein aggregates via inhibiting autophagosome maturation in
neuronal cells. Cell Death Dis. 11(874)2020.PubMed/NCBI View Article : Google Scholar
|
|
55
|
He L, Fu Y, Tian Y, Wang X, Zhou X, Ding
RB, Qi X and Bao J: Antidepressants as autophagy modulators for
cancer therapy. Molecules. 28(7594)2023.PubMed/NCBI View Article : Google Scholar
|
|
56
|
Adornetto A, Lagana ML, Satriano A,
Licastro E, Corasaniti MT, Bagetta G and Russo R: The
antidepressant drug amitriptyline affects human SH-SY5Y
neuroblastoma cell proliferation and modulates autophagy. Int J Mol
Sci. 25(10415)2024.PubMed/NCBI View Article : Google Scholar
|
|
57
|
Pu T, Sun J, Ren G and Li H: Neuro-immune
crosstalk in cancer: Mechanisms and therapeutic implications.
Signal Transduct Target Ther. 10(176)2025.PubMed/NCBI View Article : Google Scholar
|
|
58
|
Pant A and Lim M: Advances in co-opting
anti-depressant drugs in glioma therapy. Cell Rep Med.
3(100837)2022.PubMed/NCBI View Article : Google Scholar
|
