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Introduction

Superior mesenteric artery (SMA) syndrome (SMAS) is a rare gastrointestinal disease, initially having been reported in 1842. Wilkie (1) reported the disease in more detail in 1927. Based on this report, SMAS has been termed as ‘Wilkie's syndrome’. The angle between the aorta and SMA of a normal individual ranges from 38˚ to 56˚. A mesenteric fat pad is present within this angle to relieve compression. SMAS occurs when this angle becomes narrow due to various reasons, including gastrointestinal dyskinesia, malabsorption, peritoneal adhesions and corrective surgery for spinal diseases, leading to the oppression of the distal end of the duodenum (2). Patients usually present with symptoms similar to intestinal obstruction, including abdominal distension and frequent vomiting (3). Frequent vomiting and the loss of digestive juices may lead to further weight loss and aggravated duodenal compression, resulting in the formation of a continuous cycle of severe symptoms. This syndrome is usually related to certain anatomical variations, including a weak body type, shortening of the Treitz ligament, a higher physiological position of the duodenum and an abnormally low position of the SMA (4). The risk factors which have been reported include gastrointestinal dyskinesia, malabsorption, peritoneal adhesion, and corrective surgery for spinal diseases (2).

SMAS can be caused by aortomesenteric angle reduction. In patients presenting with abdominal pain, nausea, anorexia, weight loss and vomiting, the diagnosis of SMA syndrome should be considered (5). The diagnostic criteria for SMA include an aortomesenteric angle <20˚ and a aortomesenteric distance <8 mm with gastric and proximal duodenal dilatation (6). The typical barium swallow (upper gastrointestinal series) of SMAS reveals abrupt or nearly total cessation of the barium flow from the duodenum to the jejunum (7). Nutritional support treatment leads to a higher rate of symptom relief. In a previous study, in a modern case series of 22 children managed for SMAS, the symptom relief rate of non-surgical treatment was 86% (8). Weight gain may increase fat in the mesenteric fat pad, covering the third part of the duodenum to relieve duodenal compression (9). Early surgery should be considered for patients who have failed nutritional support treatment. Surgical options include the lysis of the Treitz ligament, gastrojejunostomy or duodenojejunostomy (5,10-13).

The present study describes two cases of SMAS which occurred following esophageal cancer surgery and describes the symptoms presented and the treatments used. It is hoped that the findings presented herein may aid in the treatment of other similar cases in the future.

Case report

The first case included a 68-year-old female patient who was diagnosed with squamous cell carcinoma, due to weight loss (4 kg) and intermittent dysphagia. The computerized tomography (CT) scan (PHILIPS Brilliance 64) of the abdomen prior to surgery did not reveal any abnormalities (Figs. 1A and 2A). Surgical resection of the esophageal cancer was performed by trans-left thoracic esophagectomy at the People's Hospital of Kai Zhou District on January 26, 2021. The post-operative pathological examination revealed moderately differentiated esophageal squamous cell carcinoma. The pathological stage was determined as T3N0M0.

Figure 1 (A) A pre-operative enhanced CT scan of the abdomen indicates no apparent compression in the horizontal section of the duodenum (January 22, 2021). (B) An abdominal contrast-enhanced CT scan indicates beak-like stenosis at the distal end of the duodenum. The distance between the SMA and the abdominal aorta is estimated to be 11.8 mm (March 11, 2021). (C) The enhanced CT scan of the abdomen indicates that the distance between the SMA and the abdominal aorta is reduced further, and the horizontal segment of the duodenum is significantly compressed (May 15, 2021). (D) The barium swallow (upper gastrointestinal series) indicated that the descending part of the duodenum was dilated and longitudinal indentations with smooth and neat edges were noted in the horizontal part (May 15, 2021). CT, computerized tomography; SMA, superior mesenteric artery; SMV, superior mesenteric vein; AO, abdominal aorta.

Figure 2 (A) Three-dimensional reconstruction of abdominal blood vessels prior to surgery (January 22, 2021). (B) Three-dimensional reconstruction of abdominal blood vessels following the operation indicates that the angle between the superior mesenteric artery and the abdominal aorta was significantly reduced (May 15, 2021).

An esophageal lipiodol angiography confirmed the absence of esophagogastric anastomotic fistula on post-operative day 7. Therefore, the patient began drinking water and receiving oral liquid food; however, the patient also presented with a poor appetite and exhibited satiety following the consumption of only a limited portion of food. On the 10th day after surgery, the patient began to complain of symptoms of acid reflux and belching, which became more apparent following food consumption. These symptoms were not relieved after the administration of mosapride and omeprazole. The patient developed symptoms of bloating and frequent vomiting within a few minutes to half an hour after eating on post-operative day 13. Initially, it was considered that these symptoms were caused by post-operative gastroparesis and the patient was asked to suspend oral intake. The patient underwent a CT scan of the abdomen on post-operative day 16 (Fig. 1B), and no apparent abnormalities were observed. Following 7 days of parenteral nutritional support, the patient's vomiting symptoms gradually subsided and she was discharged on the 20th day post-surgery. The patient's pre-operative body mass index (BMI) was 25.5 kg/m2, which was decreased to 20.8 kg/m2 at the time of discharge.

During the first few months after the surgery, the patient repeatedly experienced a series of symptoms, including abdominal distension, vomiting and loss of appetite. Therefore, she received parenteral nutrition treatment at our department several times. Due to repeated hospitalizations, she was examined using barium swallow (upper gastrointestinal series) and an enhanced CT scan of the abdomen was performed on May 15, 2021, which indicated an apparent duodenal compression (Figs. 1C and D, and 2B). Therefore, the diagnosis of SMAS was confirmed. Since the symptoms of bloating and vomiting were not relieved following nutritional support, the patient underwent a duodenojejunostomy on May 20, 2021. During the surgery, the proximal duodenal bowel of the SMA was dilated, whereas the distal intestinal tube was free and smooth, indicating that the duodenum was compressed by the SMA. Following post-operative nutritional support, the symptoms of vomiting and abdominal distension were relieved. She was discharged 2 weeks after the surgery, having a BMI of 23.5 kg/m2.

The second case included a 66-year-old female patient who underwent radical esophageal cancer surgery four years ago. She did not receive systemic chemotherapy following the surgery, and other detailed surgical information was not available. The post-operative pathological examination revealed moderately differentiated esophageal squamous cell carcinoma. The pathological stage was determined as T2N0M0. At 1 month prior to admission to our hospital, the patient exhibited abdominal distension and intermittent vomiting without apparent cause. The symptoms did not resolve spontaneously during that time, and she was admitted to our hospital for further treatment. Following admission to the hospital, the patient underwent barium swallow (upper gastrointestinal series) (Fig. 3), which indicated that the third part of the duodenum was compressed, and the enhanced CT scan of the abdomen revealed that the proximal duodenal bowel of SMA was dilated. She was diagnosed with SMAS due to her typical clinical symptoms and specific imaging studies. Following 11 days of nutritional support, the symptoms of vomiting and abdominal distension were relieved. At 1 week after being discharged from the hospital, the patient's vomiting or abdominal distension after eating was completely relieved, and the current BMI has increased from 17.9 kg/m2 at admission to 19.2 kg/m2.

Figure 3 (A) Barium swallow (upper gastrointestinal series) indicate the proximal dilation of the horizontal part of the duodenum and the longitudinal compression marks with smooth edges at the distal end. (B) The enhanced computerized tomography scan of the abdomen demonstrates that the proximal duodenal bowel of SMA was dilated. SMA, superior mesenteric artery; AO, abdominal aorta.

Discussion

In the first case of the present case report, the most frequently used duodenal-jejunal anastomosis was used. On the 7th day following operation, the patient had his stomach tube removed and started eating. The symptoms of bloating and vomiting were significantly relieved. A duodenojejunostomy involves an end-to-side anastomosis between the duodenum and jejunum, bypassing the SMA and reducing compression. It has been reported that the symptom relief rate of duodenojejunostomy reaches 90% (14). The symptoms of the second patient were relieved by providing nutritional support treatment for 11 days.

No standard guidelines have been reported regarding the indications for surgery in this rare syndrome. In the second case, the patient's symptoms were gradually relieved after 11 days of parenteral nutrition treatment. It is considered that conservative treatment for patients with mild SMAS can be extended to 4 weeks. During treatment, oral enteral nutrition preparations can be attempted (15). When vomiting and abdominal distension are relieved, enteral and parenteral nutrition can be performed simultaneously. If the patient presents with severe abdominal distension, frequent vomiting, electrolyte balance disorder, or the symptoms of conservative treatment for a long period of time without relief, early surgical intervention should be considered. By contrast, for those patients with esophageal cancer and severe preoperative nutritional impairment, long-term eating difficulties, and/or in elderly patients, post-operative prefabricated jejunostomy may be used to reduce the incidence of SMAS. However, the risk of prefabricated jejunostomy must be carefully evaluated prior to the surgery.

SMAS is a rare disease encountered in clinical practice and it is even rarer in patients undergoing radical resection of esophageal cancer combined with SMAS. The authors believe that the main reasons for this include the following: i) The typical symptoms of milder SMAS are similar to the gastrointestinal symptoms of gastrointestinal reconstruction, following esophageal cancer resection; ii) routine examinations, including esophageal iodine contrast, chest and abdomen CT scans, and electronic gastroscopy exhibit decreased sensitivity in disease diagnosis; and iii) the severe obstructive symptoms of SMAS are similar to the symptoms of viscous intestinal obstructions, which may mislead the attending physician. Both patients reported in the present study underwent several CT scans, esophageal lipiodol and electronic gastroscopy. The SMAS of these two patients was not diagnosed at an early stage by multiple examinations, prolonging the treatment period and hospital stay. The early diagnosis of esophageal cancer is difficult. The slow progress of eating obstruction in patients with esophageal cancer may lead to a poor nutritional status, and the radical resection of esophageal cancer requires the removal of the majority of the stomach and the repositioning of the stomach into the thoracic cavity, which may result in an upward displacement of the horizontal part of the duodenum. Those processes may also cause SMAS.

In conclusion, the diagnosis of SMAS should be considered in patients following esophagectomy who have a poor oral intake and present with bloating, vomiting and other gastrointestinal obstructions.

Acknowledgements

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Funding

Funding: No funding was received.

Availability of data and materials

Not applicable.

Authors' contributions

YZ and ZLY designed the study and drafted the initial manuscript. ZLY and ZW collected the original data and information. YZ and ZLY confirm the authenticity of all the raw data. All authors have read and approved the final manuscript.

Ethics approval and consent to participate

The patients described herein provided their consent for their inclusion in the present case report, and written consent was obtained and stored electronically as a PDF.

Patient consent for publication

The patients provided their consent for the publication of personal data, and written consent was obtained and stored electronically as a PDF.

Competing interests

The authors declare that they have no competing interests.

References