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Pulmonary tuberculosis and diabetes mellitus: Epidemiology, pathogenesis and therapeutic management (Review)

  • Authors:
    • You-Fan Peng
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    Affiliations: Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi 533000, P.R. China
    Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 4
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    Published online on: December 21, 2023
       https://doi.org/10.3892/mi.2023.128
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Abstract

The dual burden of pulmonary tuberculosis (PTB) and diabetes mellitus (DM) is a major global public health concern. There is increasing evidence to indicate an association between PTB and DM. DM is associated with immune dysfunction and altered immune components. Hyperglycemia weakens the innate immune response by affecting the function of macrophages, dendritic cells, neutrophils, and natural killer cells, and also disrupts the adaptive immune response, thus promoting the susceptibility of PTB in patients with DM. Antituberculosis drugs often cause the impairment of liver and kidney function in patients with PTB, and the infection with Mycobacterium tuberculosis weaken pancreatic endocrine function by causing islet cell amyloidosis, which disrupts glucose metabolism and thus increases the risk of developing DM in patients with PTB. The present review discusses the association between PTB and DM from the perspective of epidemiology, pathogenesis, and treatment management. The present review aims to provide information for the rational formulation of treatment strategies for patients with PTB‑DM.
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1 

International Diabetes Federation. IDF Diabetes Atlas, 10th edition. International Diabetes Federation, Brussels, 2021.

2 

Zheng Y, Ley SH and Hu FB: Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 14:88–98. 2018.PubMed/NCBI View Article : Google Scholar

3 

Kaparianos A, Argyropoulou E, Sampsonas F, Karkoulias K, Tsiamita M and Spiropoulos K: Pulmonary complications in diabetes mellitus. Chron Respir Dis. 5:101–108. 2008.PubMed/NCBI View Article : Google Scholar

4 

Ali MO: Pulmonary complications in diabetes mellitus. Mymensingh Med J. 23:603–605. 2014.PubMed/NCBI

5 

Natarajan A, Beena PM, Devnikar AV and Mali S: A systemic review on tuberculosis. Indian J Tuberc. 67:295–311. 2020.PubMed/NCBI View Article : Google Scholar

6 

Zheng C, Hu M and Gao F: Diabetes and pulmonary tuberculosis: A global overview with special focus on the situation in Asian countries with high TB-DM burden. Glob Health Action. 10:1–11. 2017.PubMed/NCBI View Article : Google Scholar

7 

Li M, Chen T, Hua Z, Yan H, Wang D, Li Z, Kang Y, Zhu N and Li C: Global, regional, and national prevalence of diabetes mellitus in patients with pulmonary tuberculosis: A systematic review and meta-analysis. Diabetol Metab Syndr. 13(127)2021.PubMed/NCBI View Article : Google Scholar

8 

Mugusi F, Swai AB, Alberti KG and McLarty DG: Increased prevalence of diabetes mellitus in patients with pulmonary tuberculosis in Tanzania. Tubercle. 71:271–276. 1990.PubMed/NCBI View Article : Google Scholar

9 

Wu Q, Wang M, Zhang Y, Wang W, Ye TF, Liu K and Chen SH: Epidemiological characteristics and their influencing factors among pulmonary tuberculosis patients with and without diabetes mellitus: A survey study from drug resistance surveillance in east china. Front Public Health. 9(777000)2022.PubMed/NCBI View Article : Google Scholar

10 

Lee EH, Lee JM, Kang YA, Leem AY, Kim EY, Jung JY, Park MS, Kim YS, Kim SK, Chang J and Kim SY: Prevalence and impact of diabetes mellitus among patients with active pulmonary tuberculosis in South Korea. Lung. 195:209–215. 2017.PubMed/NCBI View Article : Google Scholar

11 

Rahim Z, Momi MS, Saha SK, Zaman K, Uddin KN, Jamil SN, Nahar N, Khan AK, Cooreman EA, Ahmed M, et al: Pulmonary tuberculosis in patients with diabetes mellitus in Bangladesh. Int J Tuberc Lung Dis. 16:1132–1133. 2012.PubMed/NCBI View Article : Google Scholar

12 

Delgado-Sánchez G, García-García L, Castellanos-Joya M, Cruz-Hervert P, Ferreyra-Reyes L, Ferreira-Guerrero E, Hernández A, Ortega-Baeza VM, Montero-Campos R, Sulca JA, et al: Association of pulmonary tuberculosis and diabetes in Mexico: Analysis of the national tuberculosis registry 2000-2012. PLoS One. 10(e0129312)2015.PubMed/NCBI View Article : Google Scholar

13 

Guo S, Lei S, Li J, Li L, Chen H and Chongsuvivatwong V: Gradient association between pulmonary tuberculosis and diabetes mellitus among households with a tuberculosis case: A contact tracing-based study. Sci Rep. 12(1854)2022.PubMed/NCBI View Article : Google Scholar

14 

Stevenson CR, Forouhi NG, Roglic G, Williams BG, Lauer JA, Dye C and Unwin N: Diabetes and tuberculosis: The impact of the diabetes epidemic on tuberculosis incidence. BMC Public Health. 7(234)2007.PubMed/NCBI View Article : Google Scholar

15 

Mave V, Meshram S, Lokhande R, Kadam D, Dharmshale S, Bharadwaj R, Kagal A, Pradhan N, Deshmukh S, Atre S, et al: Prevalence of dysglycemia and clinical presentation of pulmonary tuberculosis in Western India. Int J Tuberc Lung Dis. 21:1280–1287. 2017.PubMed/NCBI View Article : Google Scholar

16 

Wang Q, Ma A, Han X, Zhao S, Cai J, Ma Y, Zhao J, Wang Y, Dong H, Zhao Z, et al: Prevalence of type 2 diabetes among newly detected pulmonary tuberculosis patients in China: A community based cohort study. PLoS One. 8(e82660)2013.PubMed/NCBI View Article : Google Scholar

17 

Vallerskog T, Martens GW and Kornfeld H: Diabetic mice display a delayed adaptive immune response to Mycobacterium tuberculosis. J Immunol. 184:6275–6282. 2010.PubMed/NCBI View Article : Google Scholar

18 

Panda S, Seelan DM, Faisal S, Arora A, Luthra K, Palanichamy JK, Mohan A, Vikram NK, Gupta NK, Ramakrishnan L and Singh A: Chronic hyperglycemia drives alterations in macrophage effector function in pulmonary tuberculosis. Eur J Immunol. 52:1595–1609. 2022.PubMed/NCBI View Article : Google Scholar

19 

Vance J, Santos A, Sadofsky L, Morice A and Cervantes J: Effect of high glucose on human alveolar macrophage phenotype and phagocytosis of mycobacteria. Lung. 197:89–94. 2019.PubMed/NCBI View Article : Google Scholar

20 

Alim MA, Sikder S, Sathkumara H, Kupz A, Rush CM, Govan BL and Ketheesan N: Dysregulation of key cytokines may contribute to increased susceptibility of diabetic mice to Mycobacterium bovis BCG infection. Tuberculosis (Edinb). 115:113–120. 2019.PubMed/NCBI View Article : Google Scholar

21 

Martinez N, Ketheesan N, West K, Vallerskog T and Kornfeld H: Impaired recognition of mycobacterium tuberculosis by alveolar macrophages from diabetic mice. J Infect Dis. 214:1629–1637. 2016.PubMed/NCBI View Article : Google Scholar

22 

Alim MA, Sikder S, Bridson TL, Rush CM, Govan BL and Ketheesan N: Anti-mycobacterial function of macrophages is impaired in a diet induced model of type 2 diabetes. Tuberculosis (Edinb). 102:47–54. 2017.PubMed/NCBI View Article : Google Scholar

23 

Sertl K, Takemura T, Tschachler E, Ferrans VJ, Kaliner MA and Shevach EM: Dendritic cells with antigen-presenting capability reside in airway epithelium, lung parenchyma, and visceral pleura. J Exp Med. 163:436–451. 1986.PubMed/NCBI View Article : Google Scholar

24 

McWilliam AS, Marsh AM and Holt PG: Inflammatory infiltration of the upper airway epithelium during Sendai virus infection: Involvement of epithelial dendritic cells. J Virol. 71:226–236. 1997.PubMed/NCBI View Article : Google Scholar

25 

Holt PG, Stumbles PA and McWilliam AS: Functional studies on dendritic cells in the respiratory tract and related mucosal tissues. J Leukoc Biol. 66:272–275. 1999.PubMed/NCBI View Article : Google Scholar

26 

Kumar NP, Moideen K, Sivakumar S, Menon PA, Viswanathan V, Kornfeld H and Babu S: Modulation of dendritic cell and monocyte subsets in tuberculosis-diabetes co-morbidity upon standard tuberculosis treatment. Tuberculosis (Edinb). 101:191–200. 2016.PubMed/NCBI View Article : Google Scholar

27 

Kumar NP, Moideen K, Dhakshinraj SD, Banurekha VV, Nair D, Dolla C, Kumaran P and Babu S: Profiling leucocyte subsets in tuberculosis-diabetes co-morbidity. Immunology. 146:243–250. 2015.PubMed/NCBI View Article : Google Scholar

28 

Andrade BB, Kumar NP, Sridhar R, Banurekha VV, Jawahar MS, Nutman TB, Sher A and Babu S: Heightened plasma levels of heme oxygenase-1 and tissue inhibitor of metalloproteinase-4 as well as elevated peripheral neutrophil counts are associated with TB-diabetes comorbidity. Chest. 145:1244–1254. 2014.PubMed/NCBI View Article : Google Scholar

29 

Raposo-García S, Guerra-Laso JM, García-García S, Juan-García J, López-Fidalgo E, Diez-Tascón C, Nebreda-Mayoral T, López-Medrano R and Rivero-Lezcano OM: Immunological response to Mycobacterium tuberculosis infection in blood from type 2 diabetes patients. Immunol Lett. 186:41–45. 2017.PubMed/NCBI View Article : Google Scholar

30 

Eruslanov EB, Lyadova IV, Kondratieva TK, Majorov KB, Scheglov IV, Orlova MO and Apt AS: Neutrophil responses to Mycobacterium tuberculosis infection in genetically susceptible and resistant mice. Infect Immun. 73:1744–1753. 2005.PubMed/NCBI View Article : Google Scholar

31 

Vankayalapati R and Barnes PF: Innate and adaptive immune responses to human Mycobacterium tuberculosis infection. Tuberculosis. 89 (Suppl 1):S77–S80. 2009.PubMed/NCBI View Article : Google Scholar

32 

Zahran WA, Ghonaim MM, Koura BA, El-Banna H, Ali SM and El-Sheikh N: Human natural killer T cells (NKT), NK and T cells in pulmonary tuberculosis: Potential indicators for disease activity and prognosis. Egypt J Immunol. 13:67–78. 2006.PubMed/NCBI

33 

Zhang Q, Xiao HP, Cui HY and Sugawara I: Significant increase in natural-killer T cells in patients with tuberculosis complicated by type 2 diabetes mellitus. J Int Med Res. 39:105–111. 2011.PubMed/NCBI View Article : Google Scholar

34 

Kumar NP, Sridhar R, Nair D, Banurekha VV, Nutman TB and Babu S: Type 2 diabetes mellitus is associated with altered CD8(+) T and natural killer cell function in pulmonary tuberculosis. Immunology. 144:677–686. 2015.PubMed/NCBI View Article : Google Scholar

35 

Cheekatla SS, Tripathi D, Venkatasubramanian S, Nathella PK, Paidipally P, Ishibashi M, Welch E, Tvinnereim AR, Ikebe M, Valluri VL, et al: NK-CD11c+ cell crosstalk in diabetes enhances IL-6-mediated inflammation during mycobacterium tuberculosis infection. PLoS Pathog. 12(e1005972)2016.PubMed/NCBI View Article : Google Scholar

36 

Prezzemolo T, Guggino G, La Manna MP, Di Liberto D, Dieli F and Caccamo N: Functional signatures of human CD4 and CD8 T cell responses to mycobacterium tuberculosis. Front Immunol. 5(180)2014.PubMed/NCBI View Article : Google Scholar

37 

St Paul M and Ohashi PS: The roles of CD8+ T cell subsets in antitumor immunity. Trends Cell Biol. 30:695–704. 2020.PubMed/NCBI View Article : Google Scholar

38 

Mayer-Barber KD and Barber DL: Innate and adaptive cellular immune responses to mycobacterium tuberculosis infection. Cold Spring Harb Perspect Med. 5(a018424)2015.PubMed/NCBI View Article : Google Scholar

39 

Ponnana M, Pydi S and Gaddam S: Enumeration of lymphocyte subsets during follow-up in the pulmonary tuberculosis patients with co morbid diabetes mellitus. Clin Chim Acta. 510:566–572. 2020.PubMed/NCBI View Article : Google Scholar

40 

Kumar NP, Sridhar R, Banurekha VV, Jawahar MS, Nutman TB and Babu S: Expansion of pathogen-specific T-helper 1 and T-helper 17 cells in pulmonary tuberculosis with coincident type 2 diabetes mellitus. J Infect Dis. 208:739–7348. 2013.PubMed/NCBI View Article : Google Scholar

41 

Stalenhoef JE, Alisjahbana B, Nelwan EJ, van der Ven-Jongekrijg J, Ottenhoff TH, van der Meer JW, Nelwan RH, Netea MG and van Crevel R: The role of interferon-gamma in the increased tuberculosis risk in type 2 diabetes mellitus. Eur J Clin Microbiol Infect Dis. 27:97–103. 2008.PubMed/NCBI View Article : Google Scholar

42 

Fernández RDV, Díaz A, Bongiovanni B, Gallucci G, Bértola D, Gardeñez W, Lioi S, Bertolin Y, Galliano R, Bay ML, et al: Evidence for a more disrupted immune-endocrine relation and cortisol immunologic influences in the context of tuberculosis and type 2 diabetes comorbidity. Front Endocrinol (Lausanne). 11(126)2020.PubMed/NCBI View Article : Google Scholar

43 

Sun Q, Zhang Q, Xiao H, Cui H and Su B: Significance of the frequency of CD4+CD25+CD127- T-cells in patients with pulmonary tuberculosis and diabetes mellitus. Respirology. 17:876–882. 2012.PubMed/NCBI View Article : Google Scholar

44 

Kathamuthu GR, Kumar NP, Moideen K, Dolla C, Kumaran P and Babu S: Multi-dimensionality immunophenotyping analyses of MAIT cells expressing Th1/Th17 cytokines and cytotoxic markers in latent tuberculosis diabetes comorbidity. Pathogens. 11(87)2022.PubMed/NCBI View Article : Google Scholar

45 

Kathamuthu GR, Kumar NP, Moideen K, Menon PA and Babu S: Decreased frequencies of Gamma/Delta T cells expressing Th1/Th17 cytokine, cytotoxic, and immune markers in latent tuberculosis-diabetes/pre-diabetes comorbidity. Front Cell Infect Microbiol. 11(756854)2021.PubMed/NCBI View Article : Google Scholar

46 

Wei R, Li P, Xue Y, Liu Y, Gong W and Zhao W: Impact of diabetes mellitus on the immunity of tuberculosis patients: A retrospective, cross-sectional study. Risk Manag Healthc Policy. 15:611–627. 2022.PubMed/NCBI View Article : Google Scholar

47 

Kumar NP, Moideen K, George PJ, Dolla C, Kumaran P and Babu S: Impaired cytokine but enhanced cytotoxic marker expression in mycobacterium tuberculosis-induced CD8+ T cells in individuals with type 2 diabetes and latent mycobacterium tuberculosis infection. J Infect Dis. 213:866–870. 2016.PubMed/NCBI View Article : Google Scholar

48 

Wang X, Ma A, Han X, Chan L, Liang H, Litifu A and Xue F: T cell profile was altered in pulmonary tuberculosis patients with type 2 diabetes. Med Sci Monit. 24:636–642. 2018.PubMed/NCBI View Article : Google Scholar

49 

Kumar NP, Moideen K, Viswanathan V, Kornfeld H and Babu S: Effect of standard tuberculosis treatment on naive, memory and regulatory T-cell homeostasis in tuberculosis-diabetes co-morbidity. Immunology. 149:87–97. 2016.PubMed/NCBI View Article : Google Scholar

50 

Kumar S, Lakhiwal R, Singh CP, Bhandiwad C, Sharma N, Singhal V and Chakranarayan A: Study of correlation of CD4, CD8 count with tuberculous pneumonia and non tuberculous bacterial pneumonia in type 2 diabetes mellitu. J Assoc Physicians India. 70:11–12. 2022.PubMed/NCBI

51 

Kumar NP, Moideen K, Dolla C, Kumaran P and Babu S: Prediabetes is associated with the modulation of antigen-specific Th1/Tc1 and Th17/Tc17 responses in latent Mycobacterium tuberculosis infection. PLoS One. 12(e0178000)2017.PubMed/NCBI View Article : Google Scholar

52 

Mily A, Sarker P, Taznin I, Hossain D, Haq MA, Kamal SMM, Agerberth B, Brighenti S and Raqib R: Slow radiological improvement and persistent low-grade inflammation after chemotherapy in tuberculosis patients with type 2 diabetes. BMC Infect Dis. 20(933)2020.PubMed/NCBI View Article : Google Scholar

53 

Guo Q, Zhang J, Li G, Liu S, Xiao G, Bi J, Li F, Zhang S, Ou M, He X, et al: Elevated antigen-specific IFN-γ responses in bronchoalveolar lavage fluid impervious to clinical comorbidities improve the pulmonary tuberculosis diagnosis. Tuberculosis (Edinb). 122(101942)2020.PubMed/NCBI View Article : Google Scholar

54 

Yamashiro S, Kawakami K, Uezu K, Kinjo T, Miyagi K, Nakamura K and Saito A: Lower expression of Th1-related cytokines and inducible nitric oxide synthase in mice with streptozotocin-induced diabetes mellitus infected with Mycobacterium tuberculosis. Clin Exp Immunol. 139:57–64. 2005.PubMed/NCBI View Article : Google Scholar

55 

Meenakshi P, Ramya S, Lavanya J, Vijayalakshmi V and Sumanlatha G: Effect of IFN-γ, IL-12 and IL-10 cytokine production and mRNA expression in tuberculosis patients with diabetes mellitus and their household contacts. Cytokine. 81:127–136. 2016.PubMed/NCBI View Article : Google Scholar

56 

Gan SH, KhinMar KW, Barkham TM, Koh CK, Shen L, Wang YT and Chee CB: Interferon-γ responses to Mycobacterium tuberculosis-specific antigens in diabetes mellitus. Eur Respir J. 44:805–808. 2014.PubMed/NCBI View Article : Google Scholar

57 

Karachunskiĭ MA, Balabolkin MI and Beglarian NR: Changes in carbohydrate metabolism in patients with tuberculosis. Vestn Ross Akad Med Nauk. 7:18–21. 1995.PubMed/NCBI(In Russian).

58 

Chen H, Su L, Bao J, Zhang K, Li Y and Mao E: The impact of pulmonary tuberculosis on immunological and metabolic features of diabetic patients. Front Immunol. 13(973991)2022.PubMed/NCBI View Article : Google Scholar

59 

Segura-Cerda CA, Marquina-Castillo B, Lozano-Ordaz V, Mata-Espinosa D, Barrios-Payán JA, López-Torres MO, Aceves-Sánchez MJ, Bielefeldt-Ohmann H, Hernández-Pando R and Flores-Valdez MA: BCG and BCGΔBCG1419c protect type 2 diabetic mice against tuberculosis via different participation of T and B lymphocytes, dendritic cells and pro-inflammatory cytokines. NPJ Vaccines. 5(21)2020.PubMed/NCBI View Article : Google Scholar

60 

Adeva-Andany MM, Pérez-Felpete N, Fernández-Fernández C, Donapetry-García C and Pazos-García C: Liver glucose metabolism in humans. Biosci Rep. 36(e00416)2016.PubMed/NCBI View Article : Google Scholar

61 

Legouis D, Faivre A, Cippà PE and de Seigneux S: Renal gluconeogenesis: An underestimated role of the kidney in systemic glucose metabolism. Nephrol Dial Transplant. 37:1417–1425. 2022.PubMed/NCBI View Article : Google Scholar

62 

Gray EL and Goldberg HF: Baseline abnormal liver function tests are more important than age in the development of isoniazid-induced hepatoxicity for patients receiving preventive therapy for latent tuberculosis infection. Intern Med J. 46:281–287. 2016.PubMed/NCBI View Article : Google Scholar

63 

Becker MW, Schwambach KH, Lunardelli M and Blatt CR: Overview of drug induced liver injury in Brazil: What is the role of public health policy on the evidence? World J Gastrointest Pharmacol Ther. 12:40–55. 2021.PubMed/NCBI View Article : Google Scholar

64 

Covic A, Golea O, Segall L, Meadipudi S, Munteanu L, Nicolicioiu M, Tudorache V, Covic M and Goldsmith DJ: A clinical description of rifampicin-induced acute renal failure in 170 consecutive cases. J Indian Med Assoc. 102:22–25. 2004.PubMed/NCBI

65 

Broxmeyer L: Diabetes mellitus, tuberculosis and the mycobacteria: Two millenia of enigma. Med Hypotheses. 65:433–439. 2005.PubMed/NCBI View Article : Google Scholar

66 

Sahakyan S, Petrosyan V and Abrahamyan L: Diabetes mellitus and treatment outcomes of pulmonary tuberculosis: A cohort study. Int J Public Health. 65:37–43. 2020.PubMed/NCBI View Article : Google Scholar

67 

Ahmed M, Omer I, Osman SM and Ahmed-Abakur EH: Association between pulmonary tuberculosis and Type 2 diabetes in Sudanese patients. Int J Mycobacteriol. 6:97–101. 2017.PubMed/NCBI View Article : Google Scholar

68 

Wang Y, Dou M, Kou T, Liu Y, Lv W, Han L, Wang N, Ma A, Kok FJ, Schouten EG and Wang Q: Risk of having pulmonary tuberculosis in type 2 diabetes: A hospital-based matched case-control study. Asia Pac J Clin Nutr. 30:303–310. 2021.PubMed/NCBI View Article : Google Scholar

69 

Gil-Santana L, Almeida-Junior JL, Oliveira CA, Hickson LS, Daltro C, Castro S, Kornfeld H, Netto EM and Andrade BB: Diabetes is associated with worse clinical presentation in tuberculosis patients from Brazil: A retrospective cohort study. PLoS One. 11(e0146876)2016.PubMed/NCBI View Article : Google Scholar

70 

Ren Y, Ren H, Tian Q, Li X and Liu Y: The relationship between computed tomography appearance of pulmonary tuberculosis and blood glucose levels in 763 diabetes mellitus patients with pulmonary tuberculosis: A comparative study. Endocrine. 76:584–592. 2022.PubMed/NCBI View Article : Google Scholar

71 

Buasroung P, Petnak T, Liwtanakitpipat P and Kiertiburanakul S: Prevalence of diabetes mellitus in patients with tuberculosis: A prospective cohort study. Int J Infect Dis. 116:374–379. 2022.PubMed/NCBI View Article : Google Scholar

72 

Chiang CY, Bai KJ, Lin HH, Chien ST, Lee JJ, Enarson DA, Lee TI and Yu MC: The influence of diabetes, glycemic control, and diabetes-related comorbidities on pulmonary tuberculosis. PLoS One. 10(e0121698)2015.PubMed/NCBI View Article : Google Scholar

73 

Huangfu P, Ugarte-Gil C, Golub J, Pearson F and Critchley J: The effects of diabetes on tuberculosis treatment outcomes: An updated systematic review and meta-analysis. Int J Tuberc Lung Dis. 23:783–796. 2019.PubMed/NCBI View Article : Google Scholar

74 

Ma Y, Huang ML, Li T, DU J, Shu W, Xie SH, Wang HH, Zhu GF, Tan SY, Fu YY, et al: Role of diabetes mellitus on treatment effects in drug-susceptible initial pulmonary tuberculosis patients in China. Biomed Environ Sci. 30:671–675. 2017.PubMed/NCBI View Article : Google Scholar

75 

Brunton L, Chapner B and Knollmann B: In: The Pharmacological Basis of Therapeutics-Goodman and Gillman. Brunton L and Chapner B (eds). 12th edition. Mc Graw Hill Medical, San Diego, CA, 2011.

76 

Katzung BG, Mastres SB and Trevor AJ: Basic and Clinical Pharmacology. 14th edition. Mc Graw Hill Education, Singapore, 2018.

77 

Parida SK, Axelsson-Robertson R, Rao MV, Singh N, Master I, Lutckii A, Keshavjee S, Andersson J, Zumla A and Maeurer M: Totally drug- resistant tuberculosis and adjunct therapies. J Intern Med. 277:388–405. 2015.PubMed/NCBI View Article : Google Scholar

78 

Novita BD: Metformin: A review of its potential as enhancer for anti tuberculosis efficacy in diabetes mellitus-tuberculosis coinfection patients. Indian J Tuberc. 66:294–298. 2019.PubMed/NCBI View Article : Google Scholar

79 

Alfarisi O, Mave V, Gaikwad S, Sahasrabudhe T, Ramachandran G, Kumar H, Gupte N, Kulkarni V, Deshmukh S, Atre S, et al: Effect of diabetes mellitus on the pharmacokinetics and pharmacodynamics of tuberculosis treatment. Antimicrob Agents Chemother. 62:e01383–e01318. 2018.PubMed/NCBI View Article : Google Scholar

80 

Babalik A, Ulus IH, Bakirci N, Kuyucu T, Arpag H, Dagyildizi L and Capaner E: Plasma concentrations of isoniazid and rifampin are decreased in adult pulmonary tuberculosis patients with diabetes mellitus. Antimicrob Agents Chemother. 57:5740–5742. 2013.PubMed/NCBI View Article : Google Scholar

81 

Hsu AH, Lee JJ, Chiang CY, Li YH, Chen LK and Lin CB: Diabetes is associated with drug-resistant tuberculosis in Eastern Taiwan. Int J Tuberc Lung Dis. 17:354–356. 2013.PubMed/NCBI View Article : Google Scholar

82 

Lee YJ, Han SK, Park JH, Lee JK, Kim DK, Chung HS and Heo EY: The effect of metformin on culture conversion in tuberculosis patients with diabetes mellitus. Korean J Intern Med. 33:933–940. 2018.PubMed/NCBI View Article : Google Scholar

83 

Degner NR, Wang JY, Golub JE and Karakousis PC: Metformin use reverses the increased mortality associated with diabetes mellitus during tuberculosis treatment. Clin Infect Dis. 66:198–205. 2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Peng Y: Pulmonary tuberculosis and diabetes mellitus: Epidemiology, pathogenesis and therapeutic management (Review). Med Int 4: 4, 2024.
APA
Peng, Y. (2024). Pulmonary tuberculosis and diabetes mellitus: Epidemiology, pathogenesis and therapeutic management (Review). Medicine International, 4, 4. https://doi.org/10.3892/mi.2023.128
MLA
Peng, Y."Pulmonary tuberculosis and diabetes mellitus: Epidemiology, pathogenesis and therapeutic management (Review)". Medicine International 4.1 (2024): 4.
Chicago
Peng, Y."Pulmonary tuberculosis and diabetes mellitus: Epidemiology, pathogenesis and therapeutic management (Review)". Medicine International 4, no. 1 (2024): 4. https://doi.org/10.3892/mi.2023.128
Copy and paste a formatted citation
x
Spandidos Publications style
Peng Y: Pulmonary tuberculosis and diabetes mellitus: Epidemiology, pathogenesis and therapeutic management (Review). Med Int 4: 4, 2024.
APA
Peng, Y. (2024). Pulmonary tuberculosis and diabetes mellitus: Epidemiology, pathogenesis and therapeutic management (Review). Medicine International, 4, 4. https://doi.org/10.3892/mi.2023.128
MLA
Peng, Y."Pulmonary tuberculosis and diabetes mellitus: Epidemiology, pathogenesis and therapeutic management (Review)". Medicine International 4.1 (2024): 4.
Chicago
Peng, Y."Pulmonary tuberculosis and diabetes mellitus: Epidemiology, pathogenesis and therapeutic management (Review)". Medicine International 4, no. 1 (2024): 4. https://doi.org/10.3892/mi.2023.128
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