Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Medicine International
Join Editorial Board Propose a Special Issue
Print ISSN: 2754-3242 Online ISSN: 2754-1304
Journal Cover
March-April 2023 Volume 3 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-April 2023 Volume 3 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Validation of NoSAS score for the screening of obstructive sleep apnea

  • Authors:
    • Vasiliki Epameinondas Georgakopoulou
    • Nikos Pantazis
    • Xanthi Tsiafaki
    • Evangelia Nena
    • Anastasia Amfilochiou
    • Paschalis Steiropoulos
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Diseases‑COVID‑19 Unit, Laiko General Hospital, Medical School of National and Kapodistrian University of Athens, 11527 Athens, Greece, Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece, First Pulmonology Department, Sismanogleio Hospital, 15126 Athens, Greece, MSc in Sleep Medicine, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece, Sleep Clinic, Sismanogleio Hospital, 15126 Athens, Greece
    Copyright: © Georgakopoulou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 14
    |
    Published online on: February 22, 2023
       https://doi.org/10.3892/mi.2023.74
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Obstructive sleep apnea (OSA) is the most common sleep‑related breathing disorder (SBD) characterized by the repetitive collapse of the upper airway during sleep. The aim of the present study was to validate the Neck circumference, Obesity, Snoring, Age, Sex (NoSAS) score in a sample population and to compare its validity for OSA screening, with that of the Berlin questionnaire, STOP‑BANG questionnaire and Epworth Sleepiness Scale (ESS). A retrospective analysis was conducted on individuals, aged 18 to 80 years, who reported symptoms indicating SBD and were examined with full‑night polysomnography (PSG) at a sleep center. Demographics, anthropometric parameters, comorbidities, ESS, STOP‑BANG questionnaire, Berlin questionnaire and PSG data were obtained from the recorded data of the patients. The NoSAS score was determined using the recorded data. A total of 347 participants were enrolled in the study. The NoSAS scores identified individuals with OSA, with an area under the curve (AUC) of 0.774. The NoSAS score performed significantly better than the Berlin questionnaire (AUC 0.617) and the ESS (AUC 0.642), and similarly to STOP‑BANG (AUC 0.777) for OSA screening. Using a NoSAS score >7 to predict OSA, the sensitivity and specificity were 85.6 and 50%, respectively; using the STOP‑BANG questionnaire, for a score >2, the values were 98.32 and 22% respectively; using the Berlin questionnaire for >1 positive categories, the values were 93.6 and 20%, and using the ESS, for a score >10, the values were 30.3% and 72%, respectively. On the whole, the present study demonstrates that the NoSAS score is a simple, efficient and easy method for screening OSA in the clinical setting. The NoSAS score performs significantly more efficiently than the Berlin questionnaire and ESS, and similarly to STOP‑BANG questionnaire for OSA screening.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Archontogeorgis K, Nena E, Papanas N and Steiropoulos P: Biomarkers to improve diagnosis and monitoring of obstructive sleep apnea syndrome: Current status and future perspectives. Pulm Med. 2014(930535)2014.PubMed/NCBI View Article : Google Scholar

2 

Benjafield AV, Ayas NT, Eastwood PR, Heinzer R, Ip MSM, Morrell MJ, Nunez CM, Patel SR, Penzel T, Pépin JL, et al: Estimation of the global prevalence and burden of obstructive sleep apnoea: A literature-based analysis. Lancet Respir Med. 7:687–698. 2019.PubMed/NCBI View Article : Google Scholar

3 

Pafili K, Steiropoulos P and Papanas N: The relationship between obstructive sleep apnoea and coronary heart disease. Curr Opin Cardiol. 30:439–446. 2015.PubMed/NCBI View Article : Google Scholar

4 

Perantoni E, Filos D, Archontogeorgis K, Steiropoulos P and Chouvarda IC: Pre-diabetic patients with severe obstructive sleep apnea: Novel parameters of hypoxia during sleep correlate with insulin resistance. Annu Int Conf IEEE Eng Med Biol Soc. 2019:5002–5005. 2019.PubMed/NCBI View Article : Google Scholar

5 

Bouloukaki I, Grote L, McNicholas WT, Hedner J, Verbraecken J, Parati G, Lombardi C, Basoglu OK, Pataka A, Marrone O, et al: Mild obstructive sleep apnea increases hypertension risk, challenging traditional severity classification. J Clin Sleep Med. 16:889–898. 2020.PubMed/NCBI View Article : Google Scholar

6 

Garvey JF, Pengo MF, Drakatos P and Kent BD: Epidemiological aspects of obstructive sleep apnea. J Thorac Dis. 7:920–929. 2015.PubMed/NCBI View Article : Google Scholar

7 

Hong C, Chen R, Qing S, Kuang A, Yang H, Su X, Zhao D, Wu K and Zhang N: Validation of the NoSAS score for the screening of sleep-disordered breathing: A hospital-based retrospective study in China. J Clin Sleep Med. 14:191–197. 2018.PubMed/NCBI View Article : Google Scholar

8 

Johns MW: A new method for measuring daytime sleepiness: The Epworth sleepiness scale. Sleep. 14:540–545. 1991.PubMed/NCBI View Article : Google Scholar

9 

Chung F, Yegneswaran B, Liao P, Chung SA, Vairavanathan S, Islam S, Khajehdehi A and Shapiro CM: STOP questionnaire: A tool to screen patients for obstructive sleep apnea. Anesthesiology. 108:812–821. 2008.PubMed/NCBI View Article : Google Scholar

10 

Netzer NC, Stoohs RA, Netzer CM, Clark K and Strohl KP: Using the Berlin questionnaire to identify patients at risk for the sleep apnea syndrome. Ann Intern Med. 131:485–491. 1999.PubMed/NCBI View Article : Google Scholar

11 

Marti-Soler H, Hirotsu C, Marques-Vidal P, Vollenweider P, Waeber G, Preisig M, Tafti M, Tufik SB, Bittencourt L, Tufik S, et al: The NoSAS score for screening of sleep-disordered breathing: A derivation and validation study. Lancet Respir Med. 4:742–748. 2016.PubMed/NCBI View Article : Google Scholar

12 

Tsara V, Serasli E, Amfilochiou A, Constantinidis T and Christaki P: Greek version of the Epworth sleepiness scale. Sleep Breath. 8:91–95. 2004.PubMed/NCBI View Article : Google Scholar

13 

Pataka A, Chavouzis N, Passa KF, Bagalas V, Pitsiou G, Stanopoulos I, Kalamaras G, Paspala A, Sourla E, Vaitsi E and Argyropoulou P: Validation of the stop bang questionnaire in a sleep clinic in Greece for the prediction of mobstructive sleep apnea. Eur Respir J. 42(P4052)2013.

14 

Bouloukaki I, Komninos ID, Mermigkis C, Micheli K, Komninou M, Moniaki V, Mauroudi E, Siafakas NM and Schiza SE: Translation and validation of Berlin questionnaire in primary health care in Greece. BMC Pulm Med. 13(6)2013.PubMed/NCBI View Article : Google Scholar

15 

Berry RB, Budhiraja R, Gottlieb DJ, Gozal D, Iber C, Kapur VK, Marcus CL, Mehra R, Parthasarathy S, Quan SF, et al: Rules for scoring respiratory events in sleep: Update of the 2007 AASM manual for the scoring of sleep and associated events. Deliberations of the sleep apnea definitions task force of the American academy of sleep medicine. J Clin Sleep Med. 8:597–619. 2012.PubMed/NCBI View Article : Google Scholar

16 

Liu X: Classification accuracy and cut point selection. Stat Med. 31:2676–2686. 2012.PubMed/NCBI View Article : Google Scholar

17 

Oktay Arslan B, Uçar ZZ, Batum Ö and Orman MN: Validation of the NoSAS score for screening sleep-disordered breathing: A sleep clinic- based study in Turkey. Turk J Med Sci. 51:319–327. 2021.PubMed/NCBI View Article : Google Scholar

18 

Tan A, Hong Y, Tan LWL, van Dam RM, Cheung YY and Lee CH: Validation of NoSAS score for screening of sleep-disordered breathing in a multiethnic Asian population. Sleep Breath. 21:1033–1038. 2017.PubMed/NCBI View Article : Google Scholar

19 

Peng M, Chen R, Cheng J, Li J, Liu W and Hong C: Application value of the NoSAS score for screening sleep-disordered breathing. J Thorac Dis. 10:4774–4781. 2018.PubMed/NCBI View Article : Google Scholar

20 

Coutinho Costa J, Rebelo-Marques A, Machado JN, Gama JMR, Santos C, Teixeira F and Moita J: Validation of NoSAS (Neck, Obesity, Snoring, Age, Sex) score as a screening tool for obstructive sleep apnea: Analysis in a sleep clinic. Pulmonology. 25:263–270. 2019.PubMed/NCBI View Article : Google Scholar

21 

Herschmann S, Berger M, Haba-Rubio J and Heinzer R: Comparison of NoSAS score with Berlin and STOP-BANG scores for sleep apnea detection in a clinical sample. Sleep Med. 79:113–116. 2021.PubMed/NCBI View Article : Google Scholar

22 

Chen H, Zheng Z, Chen R, Zeng Y, Li N, Zhu J, Zhong Y, Liu H, Lu J, Zhang N and Hong C: A meta-analysis of the diagnostic value of NoSAS in patients with sleep apnea syndrome. Sleep Breath. 26:519–531. 2022.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
Copy and paste a formatted citation
Spandidos Publications style
Georgakopoulou VE, Pantazis N, Tsiafaki X, Nena E, Amfilochiou A and Steiropoulos P: Validation of NoSAS score for the screening of obstructive sleep apnea. Med Int 3: 14, 2023.
APA
Georgakopoulou, V.E., Pantazis, N., Tsiafaki, X., Nena, E., Amfilochiou, A., & Steiropoulos, P. (2023). Validation of NoSAS score for the screening of obstructive sleep apnea. Medicine International, 3, 14. https://doi.org/10.3892/mi.2023.74
MLA
Georgakopoulou, V. E., Pantazis, N., Tsiafaki, X., Nena, E., Amfilochiou, A., Steiropoulos, P."Validation of NoSAS score for the screening of obstructive sleep apnea". Medicine International 3.2 (2023): 14.
Chicago
Georgakopoulou, V. E., Pantazis, N., Tsiafaki, X., Nena, E., Amfilochiou, A., Steiropoulos, P."Validation of NoSAS score for the screening of obstructive sleep apnea". Medicine International 3, no. 2 (2023): 14. https://doi.org/10.3892/mi.2023.74
Copy and paste a formatted citation
x
Spandidos Publications style
Georgakopoulou VE, Pantazis N, Tsiafaki X, Nena E, Amfilochiou A and Steiropoulos P: Validation of NoSAS score for the screening of obstructive sleep apnea. Med Int 3: 14, 2023.
APA
Georgakopoulou, V.E., Pantazis, N., Tsiafaki, X., Nena, E., Amfilochiou, A., & Steiropoulos, P. (2023). Validation of NoSAS score for the screening of obstructive sleep apnea. Medicine International, 3, 14. https://doi.org/10.3892/mi.2023.74
MLA
Georgakopoulou, V. E., Pantazis, N., Tsiafaki, X., Nena, E., Amfilochiou, A., Steiropoulos, P."Validation of NoSAS score for the screening of obstructive sleep apnea". Medicine International 3.2 (2023): 14.
Chicago
Georgakopoulou, V. E., Pantazis, N., Tsiafaki, X., Nena, E., Amfilochiou, A., Steiropoulos, P."Validation of NoSAS score for the screening of obstructive sleep apnea". Medicine International 3, no. 2 (2023): 14. https://doi.org/10.3892/mi.2023.74
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team