Open Access

Primary pancreatic synovial sarcoma: Report of a rare case and review of the literature

  • Authors:
    • Rebaz M. Ali
    • Karzan Seerwan
    • Shano M. Ali
    • Ari M. Abdullah
    • Omar Hawrami
    • Dlsoz M. Hussein
    • Bruj Jamil Mohammed
    • Muhammad Karim
    • Fakher Abdullah
    • Berun A. Abdalla
    • Fahmi H. Kakamad
  • View Affiliations

  • Published online on: March 24, 2023     https://doi.org/10.3892/mi.2023.82
  • Article Number: 22
  • Copyright: © Ali et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Synovial sarcoma is a mesenchymal spindle cell tumor. Primary pancreatic sarcomas are extremely rare. The present study describes a rare case of synovial sarcoma in the head of the pancreas. A 35‑year‑old male presented with left upper quadrant abdominal pain. An endoscopic ultrasound examination revealed a complex solid‑cystic lesion in the pancreatic head. He had undergone pancreaticoduodenectomy (Whipple procedure). A histological examination yielded negative results for AE1/AE3, CD10, S100, CD34, desmin, smooth muscle actin, β‑catenin, CD117, HMB45, chromogranin and synaptophysin. However, the results were positive for TLEI and vimentin, which is consistent with synovial sarcoma. Synovial sarcoma is a soft tissue malignant tumor. Primary pancreatic sarcomas frequently present as large, high‑grade tumors in the pancreatic head. Histologically, there are several types of synovial sarcoma, such as monophasic, biphasic and poorly differentiated. A histological examination is necessary for the diagnosis as the imaging findings are not specifically suggestive of synovial sarcoma. The preferred course of treatment is complete resection with wide margins, followed by adjuvant chemotherapy and/or radiotherapy. Primary mesenchymal tumors of the pancreas are extremely uncommon. As a result, a diagnosis requires careful evaluation. Surgical resection is the main modality of treatment.
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May-June 2023
Volume 3 Issue 3

Print ISSN: 2754-3242
Online ISSN:2754-1304

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Spandidos Publications style
Ali RM, Seerwan K, Ali SM, Abdullah AM, Hawrami O, Hussein DM, Mohammed BJ, Karim M, Abdullah F, Abdalla BA, Abdalla BA, et al: Primary pancreatic synovial sarcoma: Report of a rare case and review of the literature. Med Int 3: 22, 2023.
APA
Ali, R.M., Seerwan, K., Ali, S.M., Abdullah, A.M., Hawrami, O., Hussein, D.M. ... Kakamad, F.H. (2023). Primary pancreatic synovial sarcoma: Report of a rare case and review of the literature. Medicine International, 3, 22. https://doi.org/10.3892/mi.2023.82
MLA
Ali, R. M., Seerwan, K., Ali, S. M., Abdullah, A. M., Hawrami, O., Hussein, D. M., Mohammed, B. J., Karim, M., Abdullah, F., Abdalla, B. A., Kakamad, F. H."Primary pancreatic synovial sarcoma: Report of a rare case and review of the literature". Medicine International 3.3 (2023): 22.
Chicago
Ali, R. M., Seerwan, K., Ali, S. M., Abdullah, A. M., Hawrami, O., Hussein, D. M., Mohammed, B. J., Karim, M., Abdullah, F., Abdalla, B. A., Kakamad, F. H."Primary pancreatic synovial sarcoma: Report of a rare case and review of the literature". Medicine International 3, no. 3 (2023): 22. https://doi.org/10.3892/mi.2023.82