Malignant character of an ossified posterior longitudinal ligament in a hyperflexion injury: A case report

Fotakopoulos,George; Georgakopoulou,Vasiliki Epameinondas; Trakas,Nikolaos; Sklapani,Pagona; Brotis,Alexandros G.

doi:10.3892/mi.2024.172

September-October 2024 Volume 4 Issue 5

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

September-October 2024 Volume 4 Issue 5

Full Size Image

Case Report Open Access

Malignant character of an ossified posterior longitudinal ligament in a hyperflexion injury: A case report

Authors:
- George Fotakopoulos
- Vasiliki Epameinondas Georgakopoulou
- Nikolaos Trakas
- Pagona Sklapani
- Alexandros G. Brotis
View Affiliations / Copyright

Affiliations: Department of Neurosurgery, General University Hospital of Larissa, 41221 Larissa, Greece, Department of Pathophysiology, National and Kapodistrian University of Athens, 11527 Athens, Greece, Department of Biochemistry, Sismanogleio Hospital, 15126 Athens, Greece

Copyright: © Fotakopoulos et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
Article Number: 48
|
Published online on: June 26, 2024

https://doi.org/10.3892/mi.2024.172
Expand metrics +

Abstract

The present study reports the case of a 50‑year‑old obese male with ankylosing spondylitis, Scheuermann's kyphosis. The patient was asymptomatic concerning the ectopic ossification of the posterior longitudinal ligament (OPLL) at the cervical spine; he developed quadriparesis and respiratory insufficiency following minor head trauma. Even though trauma to the cervical spine in patients with OPLL is common, to the best of our knowledge, this is the first reported case of an extensive osteophyte with a lethal outcome after syncope. In rare occasions, it may be present with syncope and potentially lethal outcomes, particularly when precipitated by trauma. Therefore, the management of OPLL with significant canal stenosis should not be unnecessarily delayed.

View Figures

View References

1	Matsunaga S and Sakou T: Ossification of the posterior longitudinal ligament of the cervical spine: Etiology and natural history. Spine (Phila Pa 1976). 37:E309–E314. 2012.PubMed/NCBI View Article : Google Scholar
2	Head J, Rymarczuk G, Stricsek G, Velagapudi L, Maulucci C, Hoelscher C and Harrop J: Ossification of the posterior longitudinal ligament: Surgical approaches and associated complications. Neurospine. 16:517–529. 2019.PubMed/NCBI View Article : Google Scholar
3	Abiola R, Rubery P and Mesfin A: Ossification of the posterior longitudinal ligament: Etiology, diagnosis, and outcomes of nonoperative and operative management. Global Spine J. 6:195–204. 2016.PubMed/NCBI View Article : Google Scholar
4	Hirai T, Yoshii T, Ushio S, Mori K, Maki S, Katsumi K, Nagoshi N, Takeuchi K, Furuya T, Watanabe K, et al: Clinical characteristics in patients with ossification of the posterior longitudinal ligament: A prospective multi-institutional cross-sectional study. Sci Rep. 10(5532)2020.PubMed/NCBI View Article : Google Scholar
5	Verma SK, Yaseen M, Bharadwaj V and Pasha A: Syncope: A rare presentation of Cervical spondylosis. IOSR J Dent Med Sci. 13:90–92. 2014.
6	Ijima Y, Furuya T, Ota M, Maki S, Saito J, Kitamura M, Miyamoto T, Ohtori S, Orita S, Inage K, et al: The K-line in the cervical ossification of the posterior longitudinal ligament is different on plain radiographs and CT images. J Spine Surg. 4:403–407. 2018.PubMed/NCBI View Article : Google Scholar
7	Wu JC, Liu L, Chen YC, Huang WC, Chen TJ and Cheng H: Ossification of the posterior longitudinal ligament in the cervical spine: An 11-year comprehensive national epidemiology study. Neurosurg Focus. 30(E5)2011.PubMed/NCBI View Article : Google Scholar
8	Wang PN, Chen SS, Liu HC, Fuh JL, Kuo BI and Wang SJ: Ossification of the posterior longitudinal ligament of the spine. A case-control risk factor study. Spine (Phila Pa 1976). 24:142–144. 1999.PubMed/NCBI View Article : Google Scholar
9	Inamasu J, Guiot BH and Sachs DC: Ossification of the posterior longitudinal ligament: An update on its biology, epidemiology, and natural history. Neurosurgery. 58:1027–1039. 2006.PubMed/NCBI View Article : Google Scholar
10	Harvey AE, Lashinger LM and Hursting SD: The growing challenge of obesity and cancer: An inflammatory issue. Ann N Y Acad Sci. 1229:45–52. 2011.PubMed/NCBI View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Malignant character of an ossified posterior longitudinal ligament in a hyperflexion injury: A case report

This article is mentioned in:

Abstract

Figure 1

Figure 2

Related Articles