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Comparison of cost of care in patients with flares vs. remission in ulcerative colitis: A perspective from a developing country

  • Authors:
    • Ashutosh I. Yadav
    • Vishavdeep Singh Rana
    • Amol N. Patil
    • Parna Pathak
    • Usha Dutta
    • Vishal Sharma
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India, Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
    Copyright: © Yadav et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 75
    |
    Published online on: October 3, 2025
       https://doi.org/10.3892/mi.2025.274
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Abstract

Ulcerative colitis (UC) is a chronic relapsing‑remitting disease that results in not only physical, mental and social, but also a significant financial burden to patients and their caregivers. The present study aimed to analyse the monthly cost of care for patients with UC in remission during their regular follow‑up and compare this to the expenses born during an episode of acute exacerbation in order to estimate the costs of such episodes of acute severe UC (ASUC). Patients in remission defined using the simple clinical colitis activity index (SCCAI) of <3 were recruited from the outpatient department. Patients with flares were those requiring admission for ASUC. Demographic and clinical data were recorded for each patient. A prevalence‑based, micro‑costing, human capital approach was used to estimate the direct and indirect monthly per capita mean cost‑of‑illness. The present study enrolled 25 patients with UC who were in remission (SCCAI of <3) and 51 patients with UC who presented with flares and required hospitalisation for ASUC between January, 2022 to June, 2024. The average monthly cost of care for patients with UC in remission in a tertiary government setup was calculated to be 4,112/‑ INR. The direct medical cost was 3,676/‑ INR and the direct non‑medical cost was 435/‑ INR. The cost of management of an episode of ASUC was 44,634/‑ INR per individual per episode. The direct medical cost was 20,038/‑ INR, the direct non‑medical cost was 4,087/‑ INR and the indirect cost was 20,509/‑ INR. The cost of the flares managed surgically was 155,967±100,554/‑ INR, which was significantly higher than that of flares managed medically (26,922±22,751/‑ INR; P<0.001). The cost of illness during episodes of acute flares contribute disproportionately to a high financial burden in care of patients with UC. Direct medical costs due to the cost of medications is a major contributor to the cost of care for patients with UC in remission whereas during a period of flares, the indirect cost due to productivity loss is responsible for the majority of the financial burden.
View Figures

Figure 1

Cost of care for patients with
ulcerative colitis in remission compared to patients with flares
(acute severe ulcerative colitis). INR, Indian rupee.
View References

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Spandidos Publications style
Yadav AI, Rana VS, Patil AN, Pathak P, Dutta U and Sharma V: Comparison of cost of care in patients with flares vs. remission in ulcerative colitis: A perspective from a developing country. Med Int 5: 75, 2025.
APA
Yadav, A.I., Rana, V.S., Patil, A.N., Pathak, P., Dutta, U., & Sharma, V. (2025). Comparison of cost of care in patients with flares vs. remission in ulcerative colitis: A perspective from a developing country. Medicine International, 5, 75. https://doi.org/10.3892/mi.2025.274
MLA
Yadav, A. I., Rana, V. S., Patil, A. N., Pathak, P., Dutta, U., Sharma, V."Comparison of cost of care in patients with flares vs. remission in ulcerative colitis: A perspective from a developing country". Medicine International 5.6 (2025): 75.
Chicago
Yadav, A. I., Rana, V. S., Patil, A. N., Pathak, P., Dutta, U., Sharma, V."Comparison of cost of care in patients with flares vs. remission in ulcerative colitis: A perspective from a developing country". Medicine International 5, no. 6 (2025): 75. https://doi.org/10.3892/mi.2025.274
Copy and paste a formatted citation
x
Spandidos Publications style
Yadav AI, Rana VS, Patil AN, Pathak P, Dutta U and Sharma V: Comparison of cost of care in patients with flares vs. remission in ulcerative colitis: A perspective from a developing country. Med Int 5: 75, 2025.
APA
Yadav, A.I., Rana, V.S., Patil, A.N., Pathak, P., Dutta, U., & Sharma, V. (2025). Comparison of cost of care in patients with flares vs. remission in ulcerative colitis: A perspective from a developing country. Medicine International, 5, 75. https://doi.org/10.3892/mi.2025.274
MLA
Yadav, A. I., Rana, V. S., Patil, A. N., Pathak, P., Dutta, U., Sharma, V."Comparison of cost of care in patients with flares vs. remission in ulcerative colitis: A perspective from a developing country". Medicine International 5.6 (2025): 75.
Chicago
Yadav, A. I., Rana, V. S., Patil, A. N., Pathak, P., Dutta, U., Sharma, V."Comparison of cost of care in patients with flares vs. remission in ulcerative colitis: A perspective from a developing country". Medicine International 5, no. 6 (2025): 75. https://doi.org/10.3892/mi.2025.274
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