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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March-April 2011 Volume 4 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

STAT3 enhances intracellular Fas-mediated apoptotic signals in HHUA human endometrial epithelial cells

  • Authors:
    • Tetsuji Tanaka
    • Tao Bai
    • Hirotoshi Utsunomiya
    • Takahiro Fukumoto
    • Kazunori Yukawa

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Wakayama Medical University, Wakayama 641-0012, Japan, Department of Experimental Pathology, Wakayama Medical University, Wakayama 641-0012, Japan, Research Center for Infection-Associated Cancer, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan, Department of Physiology, Faculty of Pharmacy, Meijo University, Nagoya 468-8503, Japan
  • Pages: 307-312
    |
    Published online on: January 12, 2011
       https://doi.org/10.3892/mmr.2011.424
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Abstract

Several endometrial signal transducer and activator of transcription 3 (STAT3)-activating cytokines are reported to be essential for blastocyst implantation, with inhibition of STAT3 activation in the endometrium also reported to prevent implantation. To investigate STAT3 signals in endometrial epithelial cells, the activation and inactivation effects of STAT3 signals were examined in the human endometrial epithelial cell line HHUA, which is thought to retain many of the intracellular signaling pathways found in normal human endometrial epithelial cells. Five STAT3-activating cytokines, IL-11, IL-10, LIF, oncostatin M and leptin, enhanced the Fas-mediated apoptosis of the HHUA cells without any increase in cell surface Fas antigen expression. STAT3 siRNA transfection suppressed STAT3 expression in HHUA cells and significantly inhibited Fas-mediated cell death. These results indicate that intracellular apoptotic signals in HHUA cells are constitutively activated and regulated by STAT3-mediated signals. This apoptosis-promoting effect of STAT3 in HHUA cells is completely different from many previous reports demonstrating anti-apoptotic effects by STAT3 activation. The STAT3 signals in HHUA cells may be specific to the human endometrial epithelial cell lineage in the regulation of blastocyst implantation.

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Copy and paste a formatted citation
Spandidos Publications style
Tanaka T, Bai T, Utsunomiya H, Fukumoto T and Yukawa K: STAT3 enhances intracellular Fas-mediated apoptotic signals in HHUA human endometrial epithelial cells. Mol Med Rep 4: 307-312, 2011.
APA
Tanaka, T., Bai, T., Utsunomiya, H., Fukumoto, T., & Yukawa, K. (2011). STAT3 enhances intracellular Fas-mediated apoptotic signals in HHUA human endometrial epithelial cells. Molecular Medicine Reports, 4, 307-312. https://doi.org/10.3892/mmr.2011.424
MLA
Tanaka, T., Bai, T., Utsunomiya, H., Fukumoto, T., Yukawa, K."STAT3 enhances intracellular Fas-mediated apoptotic signals in HHUA human endometrial epithelial cells". Molecular Medicine Reports 4.2 (2011): 307-312.
Chicago
Tanaka, T., Bai, T., Utsunomiya, H., Fukumoto, T., Yukawa, K."STAT3 enhances intracellular Fas-mediated apoptotic signals in HHUA human endometrial epithelial cells". Molecular Medicine Reports 4, no. 2 (2011): 307-312. https://doi.org/10.3892/mmr.2011.424
Copy and paste a formatted citation
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Spandidos Publications style
Tanaka T, Bai T, Utsunomiya H, Fukumoto T and Yukawa K: STAT3 enhances intracellular Fas-mediated apoptotic signals in HHUA human endometrial epithelial cells. Mol Med Rep 4: 307-312, 2011.
APA
Tanaka, T., Bai, T., Utsunomiya, H., Fukumoto, T., & Yukawa, K. (2011). STAT3 enhances intracellular Fas-mediated apoptotic signals in HHUA human endometrial epithelial cells. Molecular Medicine Reports, 4, 307-312. https://doi.org/10.3892/mmr.2011.424
MLA
Tanaka, T., Bai, T., Utsunomiya, H., Fukumoto, T., Yukawa, K."STAT3 enhances intracellular Fas-mediated apoptotic signals in HHUA human endometrial epithelial cells". Molecular Medicine Reports 4.2 (2011): 307-312.
Chicago
Tanaka, T., Bai, T., Utsunomiya, H., Fukumoto, T., Yukawa, K."STAT3 enhances intracellular Fas-mediated apoptotic signals in HHUA human endometrial epithelial cells". Molecular Medicine Reports 4, no. 2 (2011): 307-312. https://doi.org/10.3892/mmr.2011.424
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