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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March-April 2011 Volume 4 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March-April 2011 Volume 4 Issue 2

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Article

Expression of β-catenin and cyclin D1 in epidermal stem cells of diabetic rats

  • Authors:
    • Qing-Ling Zhong
    • Fan-Rong Liu
    • De-Wu Liu
    • Yan Peng
    • Xiang-Rong Zhang

  • View Affiliations / Copyright

    Affiliations: Burns Institute, Nanchang University, Nanchang, P.R. China, Department of Pathology, Nanchang University Medical College, Nanchang, P.R. China, Center of Burn Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, P.R. China
  • Pages: 377-381
    |
    Published online on: January 25, 2011
       https://doi.org/10.3892/mmr.2011.435
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Abstract

The healing of diabetic wounds represents a formidable clinical challenge, and the molecular mechanisms invovled in diabetic wound healing are far from clear. In this study, we investigated the expression of β-catenin and cyclin D1 in the epidermal stem cells (ESCs) of diabetic rats, and explored whether the reduction of β-catenin and its downstream target in ESCs, cyclin D1, lead to poor wound healing in diabetes mellitus (DM). We found that, compared to the controls, the ESCs of diabetic rats were markedly reduced, the clone formation efficiency of the ESCs was markedly lower, and the mRNA and protein expression of β-catenin and cyclin D1 was significantly decreased. These findings suggest that the low expression of β-catenin and cyclin D1 may reduce the activity of ESCs from diabetic rats, which might be one of the important mechanisms of delayed wound healing in DM.

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Copy and paste a formatted citation
Spandidos Publications style
Zhong Q, Liu F, Liu D, Peng Y and Zhang X: Expression of β-catenin and cyclin D1 in epidermal stem cells of diabetic rats. Mol Med Rep 4: 377-381, 2011.
APA
Zhong, Q., Liu, F., Liu, D., Peng, Y., & Zhang, X. (2011). Expression of β-catenin and cyclin D1 in epidermal stem cells of diabetic rats. Molecular Medicine Reports, 4, 377-381. https://doi.org/10.3892/mmr.2011.435
MLA
Zhong, Q., Liu, F., Liu, D., Peng, Y., Zhang, X."Expression of β-catenin and cyclin D1 in epidermal stem cells of diabetic rats". Molecular Medicine Reports 4.2 (2011): 377-381.
Chicago
Zhong, Q., Liu, F., Liu, D., Peng, Y., Zhang, X."Expression of β-catenin and cyclin D1 in epidermal stem cells of diabetic rats". Molecular Medicine Reports 4, no. 2 (2011): 377-381. https://doi.org/10.3892/mmr.2011.435
Copy and paste a formatted citation
x
Spandidos Publications style
Zhong Q, Liu F, Liu D, Peng Y and Zhang X: Expression of β-catenin and cyclin D1 in epidermal stem cells of diabetic rats. Mol Med Rep 4: 377-381, 2011.
APA
Zhong, Q., Liu, F., Liu, D., Peng, Y., & Zhang, X. (2011). Expression of β-catenin and cyclin D1 in epidermal stem cells of diabetic rats. Molecular Medicine Reports, 4, 377-381. https://doi.org/10.3892/mmr.2011.435
MLA
Zhong, Q., Liu, F., Liu, D., Peng, Y., Zhang, X."Expression of β-catenin and cyclin D1 in epidermal stem cells of diabetic rats". Molecular Medicine Reports 4.2 (2011): 377-381.
Chicago
Zhong, Q., Liu, F., Liu, D., Peng, Y., Zhang, X."Expression of β-catenin and cyclin D1 in epidermal stem cells of diabetic rats". Molecular Medicine Reports 4, no. 2 (2011): 377-381. https://doi.org/10.3892/mmr.2011.435
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