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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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November-December 2011 Volume 4 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Osteopontin regulates growth and migration of human nasopharyngeal cancer cells

  • Authors:
    • Guang Yang
    • Yan Zhang
    • Jing Wu
    • Jianjun Xiong
    • Haixia Deng
    • Jiali Wang
    • Changfu Yang
    • Zhenyu Zhu

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, Zhongshan Medical College, Sun Yat-sen University, Guangdong 510080, P.R. China, The Center of Prenatal Diagnosis, Maternal and Child Health Hospital of Guangdong Province, Guangdong, P.R. China, Department of Breast Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China
  • Pages: 1169-1173
    |
    Published online on: July 21, 2011
       https://doi.org/10.3892/mmr.2011.538
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Abstract

Naspharyngeal carcinoma (NPC) is a common malignant tumor. Radiotherapy is the main treatment for patients with early-stage NPC. Some chemotherapeutic methods have been used to delay the progression of NPC during the later stages. Osteopontin (OPN), a secreted phosphoglycoprotein, has been shown to be involved in cell proliferation, migration and invasion in a variety of tumor models. However, the effect of OPN on the proliferation and migration activity of human NPC cells is still unknown. In this study, we detected the expression of OPN in NPC CNE-2 cells, and investigated the roles of OPN in CNE-2 cells. Our results show that the down-regulation of OPN inhibits the growth and migration of CNE-2 cells. Additionally, our results indicate that the cell number in the G2 phase can be regulated by OPN. We further demonstrate that OPN shRNA down-regulates the expression of MMP-2 and MMP-9, and that OPN overexpression up-regulates the expression of MMP-2 and MMP-9.

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Copy and paste a formatted citation
Spandidos Publications style
Yang G, Zhang Y, Wu J, Xiong J, Deng H, Wang J, Yang C and Zhu Z: Osteopontin regulates growth and migration of human nasopharyngeal cancer cells. Mol Med Rep 4: 1169-1173, 2011.
APA
Yang, G., Zhang, Y., Wu, J., Xiong, J., Deng, H., Wang, J. ... Zhu, Z. (2011). Osteopontin regulates growth and migration of human nasopharyngeal cancer cells. Molecular Medicine Reports, 4, 1169-1173. https://doi.org/10.3892/mmr.2011.538
MLA
Yang, G., Zhang, Y., Wu, J., Xiong, J., Deng, H., Wang, J., Yang, C., Zhu, Z."Osteopontin regulates growth and migration of human nasopharyngeal cancer cells". Molecular Medicine Reports 4.6 (2011): 1169-1173.
Chicago
Yang, G., Zhang, Y., Wu, J., Xiong, J., Deng, H., Wang, J., Yang, C., Zhu, Z."Osteopontin regulates growth and migration of human nasopharyngeal cancer cells". Molecular Medicine Reports 4, no. 6 (2011): 1169-1173. https://doi.org/10.3892/mmr.2011.538
Copy and paste a formatted citation
x
Spandidos Publications style
Yang G, Zhang Y, Wu J, Xiong J, Deng H, Wang J, Yang C and Zhu Z: Osteopontin regulates growth and migration of human nasopharyngeal cancer cells. Mol Med Rep 4: 1169-1173, 2011.
APA
Yang, G., Zhang, Y., Wu, J., Xiong, J., Deng, H., Wang, J. ... Zhu, Z. (2011). Osteopontin regulates growth and migration of human nasopharyngeal cancer cells. Molecular Medicine Reports, 4, 1169-1173. https://doi.org/10.3892/mmr.2011.538
MLA
Yang, G., Zhang, Y., Wu, J., Xiong, J., Deng, H., Wang, J., Yang, C., Zhu, Z."Osteopontin regulates growth and migration of human nasopharyngeal cancer cells". Molecular Medicine Reports 4.6 (2011): 1169-1173.
Chicago
Yang, G., Zhang, Y., Wu, J., Xiong, J., Deng, H., Wang, J., Yang, C., Zhu, Z."Osteopontin regulates growth and migration of human nasopharyngeal cancer cells". Molecular Medicine Reports 4, no. 6 (2011): 1169-1173. https://doi.org/10.3892/mmr.2011.538
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