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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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November-December 2011 Volume 4 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November-December 2011 Volume 4 Issue 6

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Article

DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells

  • Authors:
    • Chun-Feng Meng
    • Bo Su
    • Wei Li

  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, First Affiliated Hospital, China Medical University, Shenyang, P.R. China, Department of Orthopedics, Shenzhou Hospital, Shenyang Medical College, Shenyang, P.R. China, Department of Gynecology, Shengjing Hospital, China Medical University, Shenyang, P.R. China
  • Pages: 1273-1278
    |
    Published online on: August 16, 2011
       https://doi.org/10.3892/mmr.2011.557
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Abstract

To investigate the contributions of histone H3 lysine 9 acetylation and DNA methylation to p16, hMLH1 and MGMT silencing in ovarian cancer cells, we treated three ovarian cancer cell lines with Trichostatin A (TSA) and 5-aza-2'-deoxycytidine and examined the status of mRNA expression, DNA methylation and histone H3 lysine 9 acetylation at the promoter of p16, hMLH1 and MGMT. The results showed that the hypermethylated silenced tumor-related genes in the ovarian cancer cells were characterized by hypoacetylated histone H3 lysine 9. Treatment with TSA resulted in the increase of histone H3 lysine 9 acetylation at the hypermethylated promoter, but with little effects on gene expression. TSA did not contribute to DNA demethylation. 5-aza-2'-deoxycytidine treatment caused DNA demethylation, increased histone H3 lysine 9 acetylation at the hypermethylated promoter and resulted in reactivation of p16, hMLH1 and MGMT. Combined treatments synergistically increased histone H3 lysine 9 acetylation accompanied by the re-expression of the hypermethylated genes. To conclude, in ovarian cancer cells, DNA methylation and histone deacetylation act synergistically for the silencing of cancer-associated genes. DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes.

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Copy and paste a formatted citation
Spandidos Publications style
Meng C, Su B and Li W: DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells. Mol Med Rep 4: 1273-1278, 2011.
APA
Meng, C., Su, B., & Li, W. (2011). DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells. Molecular Medicine Reports, 4, 1273-1278. https://doi.org/10.3892/mmr.2011.557
MLA
Meng, C., Su, B., Li, W."DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells". Molecular Medicine Reports 4.6 (2011): 1273-1278.
Chicago
Meng, C., Su, B., Li, W."DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells". Molecular Medicine Reports 4, no. 6 (2011): 1273-1278. https://doi.org/10.3892/mmr.2011.557
Copy and paste a formatted citation
x
Spandidos Publications style
Meng C, Su B and Li W: DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells. Mol Med Rep 4: 1273-1278, 2011.
APA
Meng, C., Su, B., & Li, W. (2011). DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells. Molecular Medicine Reports, 4, 1273-1278. https://doi.org/10.3892/mmr.2011.557
MLA
Meng, C., Su, B., Li, W."DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells". Molecular Medicine Reports 4.6 (2011): 1273-1278.
Chicago
Meng, C., Su, B., Li, W."DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells". Molecular Medicine Reports 4, no. 6 (2011): 1273-1278. https://doi.org/10.3892/mmr.2011.557
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