Investigation of vasculogenic mimicry in intracranial hemangiopericytoma

  • Authors:
    • Zhen Zhang
    • Yun Han
    • Keke Zhang
    • Liangzhu Teng
  • View Affiliations

  • Published online on: August 22, 2011     https://doi.org/10.3892/mmr.2011.567
  • Pages: 1295-1298
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Abstract

Vasculogenic mimicry (VM) has increasingly been recognized as a form of angiogenesis. Previous studies have shown that the existence of VM is associated with poor clinical prognosis in certain malignant tumors. However, whether VM is present and clinically significant in intracranial hemangiopericytoma (HPC) is unknown. The present study was therefore designed to examine the expression of VM in intracranial HPC and its correlation with matrix metalloprotease-2 (MMP-2) and vascular endothelial growth factor (VEGF). A total of 17 intracranial HPC samples, along with complete clinical and pathological data, were collected for our study. Immunohistochemistry was performed to stain tissue sections for CD34, periodic acid-Schiff, VEGF and MMP-2. The levels of VEGF and MMP-2 were compared between tumor samples with and without VM. The results showed that VM existed in 12 of 17 (70.6%) intracranial HPC samples. The presence of VM in tumors was associated with tumor recurrence (P<0.05) and expression of MMP-2 (P<0.05). However, there was no difference in the expression of VEGF between groups with and without VM.

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November-December 2011
Volume 4 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhang Z, Han Y, Zhang K and Teng L: Investigation of vasculogenic mimicry in intracranial hemangiopericytoma. Mol Med Rep 4: 1295-1298, 2011
APA
Zhang, Z., Han, Y., Zhang, K., & Teng, L. (2011). Investigation of vasculogenic mimicry in intracranial hemangiopericytoma. Molecular Medicine Reports, 4, 1295-1298. https://doi.org/10.3892/mmr.2011.567
MLA
Zhang, Z., Han, Y., Zhang, K., Teng, L."Investigation of vasculogenic mimicry in intracranial hemangiopericytoma". Molecular Medicine Reports 4.6 (2011): 1295-1298.
Chicago
Zhang, Z., Han, Y., Zhang, K., Teng, L."Investigation of vasculogenic mimicry in intracranial hemangiopericytoma". Molecular Medicine Reports 4, no. 6 (2011): 1295-1298. https://doi.org/10.3892/mmr.2011.567