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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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November-December 2011 Volume 4 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

regulation of the invasion and metastasis of human glioma cells by polypeptide N-acetylgalactosaminyltransferase 2

  • Authors:
    • Jun Liu
    • Lingyan Yang
    • Meifang Jin
    • Lan Xu
    • Shiliang Wu

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, Medical College, Soochow University, Suzhou, Jiangsu 215123, P.R. China
  • Pages: 1299-1305
    |
    Published online on: August 22, 2011
       https://doi.org/10.3892/mmr.2011.569
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Abstract

Polypeptide, N-acetylgalactosaminyltransferase 2 (ppGalNAc-T2), is a member of the ppGalNAcT family which is the initial glycosyltransferase in O-glycan synthesis. Our previous studies have demonstrated that ppGalNAc-T2 plays a vital role in the process of tumor emergence and development. In this study, we aimed to determine whether ppGalNAc-T2 is correlated with the invasion and metastasis of human glioma cells. PpGalNAc-T2 sense vectors and interference vectors constructed in our laboratory were successfully transfected into SHG44 and U251 cells, which were observed through fluorescence microscopy, RT-PCR and western blot analysis. The metastasis of U251 cells was determined using a wound healing assay, and ppGalNAc-T2 was found to inhibit cell migration. By RT-PCR, glioma cell invasion assay showed that the expression of MMP-2 was increased in ppGalNAc-T2-knockdown cells, while the expression of MMP-9 and TGF-β1 was decreased in ppGalNAc-T2-overexpressing cells at the mRNA level. Meanwhile, the expression of TIMP-2 at the mRNA level was contrary to MMP-2. In summary, our findings indicate that ppGalNAc-T2 plays a poten­tial role in glioma cell migration and invasion, suggesting a new molecular therapeutic target for human malignant glioma treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Liu J, Yang L, Jin M, Xu L and Wu S: regulation of the invasion and metastasis of human glioma cells by polypeptide N-acetylgalactosaminyltransferase 2. Mol Med Rep 4: 1299-1305, 2011.
APA
Liu, J., Yang, L., Jin, M., Xu, L., & Wu, S. (2011). regulation of the invasion and metastasis of human glioma cells by polypeptide N-acetylgalactosaminyltransferase 2. Molecular Medicine Reports, 4, 1299-1305. https://doi.org/10.3892/mmr.2011.569
MLA
Liu, J., Yang, L., Jin, M., Xu, L., Wu, S."regulation of the invasion and metastasis of human glioma cells by polypeptide N-acetylgalactosaminyltransferase 2". Molecular Medicine Reports 4.6 (2011): 1299-1305.
Chicago
Liu, J., Yang, L., Jin, M., Xu, L., Wu, S."regulation of the invasion and metastasis of human glioma cells by polypeptide N-acetylgalactosaminyltransferase 2". Molecular Medicine Reports 4, no. 6 (2011): 1299-1305. https://doi.org/10.3892/mmr.2011.569
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Yang L, Jin M, Xu L and Wu S: regulation of the invasion and metastasis of human glioma cells by polypeptide N-acetylgalactosaminyltransferase 2. Mol Med Rep 4: 1299-1305, 2011.
APA
Liu, J., Yang, L., Jin, M., Xu, L., & Wu, S. (2011). regulation of the invasion and metastasis of human glioma cells by polypeptide N-acetylgalactosaminyltransferase 2. Molecular Medicine Reports, 4, 1299-1305. https://doi.org/10.3892/mmr.2011.569
MLA
Liu, J., Yang, L., Jin, M., Xu, L., Wu, S."regulation of the invasion and metastasis of human glioma cells by polypeptide N-acetylgalactosaminyltransferase 2". Molecular Medicine Reports 4.6 (2011): 1299-1305.
Chicago
Liu, J., Yang, L., Jin, M., Xu, L., Wu, S."regulation of the invasion and metastasis of human glioma cells by polypeptide N-acetylgalactosaminyltransferase 2". Molecular Medicine Reports 4, no. 6 (2011): 1299-1305. https://doi.org/10.3892/mmr.2011.569
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