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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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February 2012 Volume 5 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Increased levels of calcitonin gene-related peptide in serum accelerate fracture healing following traumatic brain injury

  • Authors:
    • Yang Song
    • Long Bi
    • Zhenyu Zhang
    • Zhaosong Huang
    • Wei Hou
    • Xu Lu
    • Pengxiao Sun
    • Yisheng Han

  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, P.R. China
  • Pages: 432-438
    |
    Published online on: October 26, 2011
       https://doi.org/10.3892/mmr.2011.645
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Abstract

The mechanisms responsible for the phenomenon of an accelerated speed of fracture healing in patients with traumatic brain injury (TBI) remain unclear. The present study was performed to test the hypothesis that TBI causes changes in calcitonin gene-related peptide (CGRP) levels in sera that enhance fracture healing. A standard closed femoral fracture was produced in rats, which were subjected to additional closed head trauma. The fracture healing was assessed 4 and 8 weeks later using micro-CT. Sera, brain tissues and muscles surrounding the fracture sites collected at 24, 48, 72 and 168 h after injury were used to detect the expression of CGRP using ELISA, immunohistochemistry and RT-PCR. Micro-CT demonstrated that fracture healing and mineralization in the TBI-fracture group occurred earlier compared to the fracture‑only group. ELISA analysis revealed a high concentration of CGRP in the TBI-fracture group (P<0.05), and immunohistochemistry assay and RT-PCR analysis revealed a significant increase in CGRP in the brain and muscle of the TBI-fracture group at 168 h after fracture (P<0.001). Our results indicate that the mechanism for the enhancement of fracture-healing secondary to traumatic brain injury is correlated to the high levels of CGRP, which may be released from the brain tissue into the serum.

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Copy and paste a formatted citation
Spandidos Publications style
Song Y, Bi L, Zhang Z, Huang Z, Hou W, Lu X, Sun P and Han Y: Increased levels of calcitonin gene-related peptide in serum accelerate fracture healing following traumatic brain injury. Mol Med Rep 5: 432-438, 2012.
APA
Song, Y., Bi, L., Zhang, Z., Huang, Z., Hou, W., Lu, X. ... Han, Y. (2012). Increased levels of calcitonin gene-related peptide in serum accelerate fracture healing following traumatic brain injury. Molecular Medicine Reports, 5, 432-438. https://doi.org/10.3892/mmr.2011.645
MLA
Song, Y., Bi, L., Zhang, Z., Huang, Z., Hou, W., Lu, X., Sun, P., Han, Y."Increased levels of calcitonin gene-related peptide in serum accelerate fracture healing following traumatic brain injury". Molecular Medicine Reports 5.2 (2012): 432-438.
Chicago
Song, Y., Bi, L., Zhang, Z., Huang, Z., Hou, W., Lu, X., Sun, P., Han, Y."Increased levels of calcitonin gene-related peptide in serum accelerate fracture healing following traumatic brain injury". Molecular Medicine Reports 5, no. 2 (2012): 432-438. https://doi.org/10.3892/mmr.2011.645
Copy and paste a formatted citation
x
Spandidos Publications style
Song Y, Bi L, Zhang Z, Huang Z, Hou W, Lu X, Sun P and Han Y: Increased levels of calcitonin gene-related peptide in serum accelerate fracture healing following traumatic brain injury. Mol Med Rep 5: 432-438, 2012.
APA
Song, Y., Bi, L., Zhang, Z., Huang, Z., Hou, W., Lu, X. ... Han, Y. (2012). Increased levels of calcitonin gene-related peptide in serum accelerate fracture healing following traumatic brain injury. Molecular Medicine Reports, 5, 432-438. https://doi.org/10.3892/mmr.2011.645
MLA
Song, Y., Bi, L., Zhang, Z., Huang, Z., Hou, W., Lu, X., Sun, P., Han, Y."Increased levels of calcitonin gene-related peptide in serum accelerate fracture healing following traumatic brain injury". Molecular Medicine Reports 5.2 (2012): 432-438.
Chicago
Song, Y., Bi, L., Zhang, Z., Huang, Z., Hou, W., Lu, X., Sun, P., Han, Y."Increased levels of calcitonin gene-related peptide in serum accelerate fracture healing following traumatic brain injury". Molecular Medicine Reports 5, no. 2 (2012): 432-438. https://doi.org/10.3892/mmr.2011.645
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