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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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February 2012 Volume 5 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Serum MMP-9 is elevated in children with asthma

  • Authors:
    • Zhu Hong
    • Ya-Mei Lin
    • Xi Qin
    • Jiang-Long Peng

  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Affiliated Hospital of Hainan Medical College, Haikou, Hainan 571101, P.R. China
  • Pages: 462-464
    |
    Published online on: November 2, 2011
       https://doi.org/10.3892/mmr.2011.656
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Abstract

This study explored the association of matrix metalloproteinase-9 (MMP-9) serum concentration and gene polymorphism with childhood asthma. Serum levels of MMP-9 were determined by sandwich enzyme-linked immunosorbent assay (ELISA) in 65 children with asthma (cases) and 68 healthy children (controls), and the -1562C/T polymorphism in MMP-9 was detected by polymerase chain reaction and restriction fragment-length polymorphism (PCR-RFLP) analysis. The results showed that the mean serum levels of MMP-9 in the children with asthma (136.53±29.96 ng/ml) were significantly higher than that in the healthy controls (45.08±12.53 ng/ml; P<0.05). At MMP-9 base position -1562, the frequencies of the genotypes CC, CT and TT in cases were 67.7, 29.2 and 3.1% and in controls were 73.5, 25.0 and 1.5%. The allele frequencies of C and T in cases vs. controls were 82.3 and 17.7% vs. 86.0 and 14.0%, respectively. No statistically significant difference was detected in genotype or allele frequency between these groups. In addition, no significant difference in serum levels of MMP-9 was observed within groups among children with different genotypes (P>0.05). Therefore, whereas serum levels of MMP-9 are associated with the occurrence of childhood asthma, the MMP-9 -1562C/T gene polymorphism has no correlation with the pathogenesis of childhood asthma.

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Copy and paste a formatted citation
Spandidos Publications style
Hong Z, Lin Y, Qin X and Peng J: Serum MMP-9 is elevated in children with asthma. Mol Med Rep 5: 462-464, 2012.
APA
Hong, Z., Lin, Y., Qin, X., & Peng, J. (2012). Serum MMP-9 is elevated in children with asthma. Molecular Medicine Reports, 5, 462-464. https://doi.org/10.3892/mmr.2011.656
MLA
Hong, Z., Lin, Y., Qin, X., Peng, J."Serum MMP-9 is elevated in children with asthma". Molecular Medicine Reports 5.2 (2012): 462-464.
Chicago
Hong, Z., Lin, Y., Qin, X., Peng, J."Serum MMP-9 is elevated in children with asthma". Molecular Medicine Reports 5, no. 2 (2012): 462-464. https://doi.org/10.3892/mmr.2011.656
Copy and paste a formatted citation
x
Spandidos Publications style
Hong Z, Lin Y, Qin X and Peng J: Serum MMP-9 is elevated in children with asthma. Mol Med Rep 5: 462-464, 2012.
APA
Hong, Z., Lin, Y., Qin, X., & Peng, J. (2012). Serum MMP-9 is elevated in children with asthma. Molecular Medicine Reports, 5, 462-464. https://doi.org/10.3892/mmr.2011.656
MLA
Hong, Z., Lin, Y., Qin, X., Peng, J."Serum MMP-9 is elevated in children with asthma". Molecular Medicine Reports 5.2 (2012): 462-464.
Chicago
Hong, Z., Lin, Y., Qin, X., Peng, J."Serum MMP-9 is elevated in children with asthma". Molecular Medicine Reports 5, no. 2 (2012): 462-464. https://doi.org/10.3892/mmr.2011.656
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